THE PREVALENCE OF TAS2R38 GENE PHENOTYPES AMONG THE PATIENTS WITH SOME ENDOCRINE SYSTEM DISORDERS

Rusudan KHUKHUNAİSHVİLİ; Marina KORİDZE; Sophiko TSKVİTİNİDZE; Nato ZOSİDZE; Marina NAGERVADZE; İrakli PARULAVA

doi:https://doi.org/10.23884/ijhsrp.2017.2.2.01

Article Details

THE PREVALENCE OF TAS2R38 GENE PHENOTYPES AMONG THE PATIENTS WITH SOME ENDOCRINE SYSTEM DISORDERS

Authors:

Rusudan KHUKHUNAİSHVİLİ | Marina KORİDZE | Sophiko TSKVİTİNİDZE | Nato ZOSİDZE | Marina NAGERVADZE | İrakli PARULAVA

Publisher:

Rojan GÜMÜŞ

Main Topics:

Promotion of health

Journal:

International Journal of Health Services Research and Policy 2017 Vol.2 Issue 2, pp.37-43

Document Type:

Article

Publication Date:

12/2017

Document Language:

English

Document ID (Org No.):

2000465679

Frequency:

Tri-annual

eISSN:

2602-3482

DOI:

https://doi.org/10.23884/ijhsrp.2017.2.2.01

Abstract:

 


PTC (phenylthiocarbamide) is one of the
focuses of interest from the medical point of view since a number of
associations of the taster/nontaster status of PTC sensitivity with various
human diseases have been found. It is estimated that ability of sense of PTC
bitterness coded by a single gene TAS2R38. The threshold at which people can
taste phenylthiocarbamide (PTC) is bimodal, and some people are tasters while,
others are nontasters. In recent years, it is actively conducted the studies of
genetic markers in various endocrine disorders. Endocrine diseases,
particularly thyroid gland prevalence statistics in Georgia is very high. The
goal of our research was to study the phenotype of PTC sensitivity among the
patients with some endocrine system disorders in the population of Ajara region
of Georgia, particularly diabetes type II and different type of goiter
(nodular, diffuse etc.) to reveal any correlation between them. A total of 319
individuals including 136 patients with endocrine system and 183 randomly
chosen healthy individuals participated in this study. Obtained results shows,
that there is an increased incidence of diffuse toxic goiter in individuals
with recessive phenotype of TAS2R38 gene and who are unable to taste PTC
bitterness. While, PTC sensibility phenotype inclined to develop nodular
goiter. Thus PTC- Sensibility phenotype may be considered one of the genetic
markers in the forms of Goiter. 


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Article Details

THE PREVALENCE OF TAS2R38 GENE PHENOTYPES AMONG THE PATIENTS WITH SOME ENDOCRINE SYSTEM DISORDERS

Authors: Rusudan KHUKHUNAİSHVİLİ | Marina KORİDZE | Sophiko TSKVİTİNİDZE | Nato ZOSİDZE | Marina NAGERVADZE | İrakli PARULAVA

Publisher: Rojan GÜMÜŞ

Main Topics: Promotion of health

Journal: International Journal of Health Services Research and Policy 2017 Vol.2 Issue 2, pp.37-43

Document Type: Article

Publication Date: 12/2017

Document Language: English

Document ID (Org No.): 2000465679

Frequency: Tri-annual

eISSN: 2602-3482

DOI: https://doi.org/10.23884/ijhsrp.2017.2.2.01

Issues

Authors:

Rusudan KHUKHUNAİSHVİLİ | Marina KORİDZE | Sophiko TSKVİTİNİDZE | Nato ZOSİDZE | Marina NAGERVADZE | İrakli PARULAVA

Publisher:

Rojan GÜMÜŞ

Main Topics:

Promotion of health

Journal:

International Journal of Health Services Research and Policy 2017 Vol.2 Issue 2, pp.37-43

Document Type:

Article

Publication Date:

12/2017

Document Language:

English

Document ID (Org No.):

2000465679

Frequency:

Tri-annual

eISSN:

2602-3482

DOI:

https://doi.org/10.23884/ijhsrp.2017.2.2.01