Comparative study of 50 gram glucose challenge test and 75 gram oral glucose tolerance test in diagnosis of gestational diabetes mellitus in high risk group.

Sangappa Virupaxappa Kashinakunti; Manjula Rangappa; Gurupadappa Shantappa Kallaganada; Kavita Hiremath

Article Details

Comparative study of 50 gram glucose challenge test and 75 gram oral glucose tolerance test in diagnosis of gestational diabetes mellitus in high risk group.

Authors:

Sangappa Virupaxappa Kashinakunti | Manjula Rangappa | Gurupadappa Shantappa Kallaganada | Kavita Hiremath

Publisher:

Eldaghayes Publisher, Tripoli, Libya

Main Topics:

Gestational diabetes mellitus | Glucose challenge test | Glucose tolerance test.

Journal:

International Journal of Medical Science and Public Health Vol.2 Issue 4, pp.829-829

Document Type:

Article

Publication Date:

5/2013

Document Language:

English

Document ID (Org No.):

2001520904

pISSN:

2320-4664

Keywords:

Abstract:

 Background: Pregnancy is a complex endocrine-metabolic adaptation and diabetogenic condition involving impaired
 cellular insulin sensitivity, increased β-cell function, and moderate elevation of blood glucose level. The threshold for a
 positive glucose challenge test (GCT) necessitating further diagnostic testing remains controversial in gestational
 diabetes mellitus (GDM).
 
 Aims & Objective: To find the association of risk factors with GDM, to evaluate the diagnostic value of GCT as
 compared to oral glucose tolerance test (OGTT) in GDM, and also to determine the optimal cut-off value of GCT with
 best sensitivity and specificity for the prediction of GDM and also to find the association of GCT between FBS and 2nd
 hour OGTT glucose level.
 
 Material and Methods: The study was conducted at Hanagal Shri Kumareshwara Hospital, Bagalkot, Karnataka, India,
 from June 2009 to February 2010. 247 pregnant women were selected for the study. Selected women were subjected to
 screening by GCT. If the blood glucose level was greater than 140 mg/dl, the GCT was considered as positive and these
 patients were subjected to 75 gm OGTT to confirm the diagnosis of GDM. The diagnosis of GDM was based on WHO
 criteria.
 
 Results: In the present study out of 247 pregnant women selected, 199 women participated, of which 26(13.06%) of
 the pregnant women were diagnosed to have GDM. Mean age of the study subjects was 24.7±3.51 years. There was a
 positive association of GDM with age, BMI, glucosuria, polyhydraromnios, obstetrics score, previous GDM, past history
 of unexplained IUD, family history of DM, recurrent vaginal infection. Area under the curve is 0.994 (p>0.0001) which
 has best diagnostic accuracy at glucose level of 128 mg/dl, as the best cut off value. Second hour OGTT is more
 correlated with GCT than FBS.
 
 Conclusion: In this ethnic group, the high risk pregnant women for GDM should undergo initial 50 gm. GCT. If GCT
 value is more than 128 mg/dl, it should be followed by second hour 75 gram OGTT, for the diagnosis of GDM and it
 reduces the FBS estimation of blood sugar level and an extra prick too.

Article Details

Comparative study of 50 gram glucose challenge test and 75 gram oral glucose tolerance test in diagnosis of gestational diabetes mellitus in high risk group.

Authors: Sangappa Virupaxappa Kashinakunti | Manjula Rangappa | Gurupadappa Shantappa Kallaganada | Kavita Hiremath

Publisher: Eldaghayes Publisher, Tripoli, Libya

Main Topics: Gestational diabetes mellitus | Glucose challenge test | Glucose tolerance test.

Journal: International Journal of Medical Science and Public Health Vol.2 Issue 4, pp.829-829

Document Type: Article

Publication Date: 5/2013

Document Language: English

Document ID (Org No.): 2001520904

pISSN: 2320-4664

Gestational diabetes mellitus

Glucose challenge test

Glucose tolerance test.

Issues

Authors:

Sangappa Virupaxappa Kashinakunti | Manjula Rangappa | Gurupadappa Shantappa Kallaganada | Kavita Hiremath

Publisher:

Eldaghayes Publisher, Tripoli, Libya

Main Topics:

Gestational diabetes mellitus | Glucose challenge test | Glucose tolerance test.

Journal:

International Journal of Medical Science and Public Health Vol.2 Issue 4, pp.829-829

Document Type:

Article

Publication Date:

5/2013

Document Language:

English

Document ID (Org No.):

2001520904

pISSN:

2320-4664