Synthesis, Characterization, and Biocidal Studies of the Newly Synthesized Di- and Triorganotin(IV) Complexes with n-Butylhydrogen Phthalate

Saqib ALI; Saira SHAHZADI

Article Details

Synthesis, Characterization, and Biocidal Studies of the Newly Synthesized Di- and Triorganotin(IV) Complexes with n-Butylhydrogen Phthalate

Authors:

Saqib ALI | Saira SHAHZADI

Publisher:

TUBITAK

Main Topics:

Applied physics

Journal:

Turkish Journal of Chemistry 2007 Vol.31 Issue 3, pp.371-387

Document Type:

Article

Publication Date:

2/2007

Document Language:

English

Document ID (Org No.):

2000728728

Frequency:

Bimonthly

eISSN:

1303-6130

pISSN:

1300-0527

Abstract:

 

Di-(1, 3, 8) and triorganotin(IV) complexes (2, 5, 7) with  the general formula RnSnL4-n, where R = Me, Et, n-Bu, n-Oct, Ph,  and Bz, and L = the n-C4H9OCOC6H4COO- monoanionic ligand have  been synthesized by the reaction of the silver salt of the  n-butylhydrogen phthalate with di- and triorganotin chloride in dry  chloroform.  However, di-n-butyl- and di-n-octyltin(IV) derivatives (4  and 6, respectively) were synthesized by the reaction of the  corresponding organotin(IV) oxide with n-butylhydrogen phthalate in  dry toluene.  All the synthesized complexes were characterized by  elemental analysis, FT-IR, multinuclear (1H, 13C, 119Sn) NMR,  and mass spectrometric techniques to assess the binding mode of the  n-butylphthalate (n-C4H9OCOC6H4COO-) anion.  The diorganotin(IV)  derivatives were found to adopt distorted octahedral and  triorganotin(IV) n-butylphthalates and to have linear, polymeric  trigonal bipyramidal structures in which n-butylphthalate is a  monoanionic bidentate coordinating through the C(O)O group.  The  biocidal activity and LD50 values of the synthesized compounds are  also reported.  Some complexes exhibited good activity comparable to  that of standard drugs.  Furthermore, triorganotin(IV) derivatives  exhibited significantly better activity than the diorganotin(IV)  derivatives.

 

Di-(1, 3, 8) and triorganotin(IV) complexes (2, 5, 7) with  the general formula RnSnL4-n, where R = Me, Et, n-Bu, n-Oct, Ph,  and Bz, and L = the n-C4H9OCOC6H4COO- monoanionic ligand have  been synthesized by the reaction of the silver salt of the  n-butylhydrogen phthalate with di- and triorganotin chloride in dry  chloroform.  However, di-n-butyl- and di-n-octyltin(IV) derivatives (4  and 6, respectively) were synthesized by the reaction of the  corresponding organotin(IV) oxide with n-butylhydrogen phthalate in  dry toluene.  All the synthesized complexes were characterized by  elemental analysis, FT-IR, multinuclear (1H, 13C, 119Sn) NMR,  and mass spectrometric techniques to assess the binding mode of the  n-butylphthalate (n-C4H9OCOC6H4COO-) anion.  The diorganotin(IV)  derivatives were found to adopt distorted octahedral and  triorganotin(IV) n-butylphthalates and to have linear, polymeric  trigonal bipyramidal structures in which n-butylphthalate is a  monoanionic bidentate coordinating through the C(O)O group.  The  biocidal activity and LD50 values of the synthesized compounds are  also reported.  Some complexes exhibited good activity comparable to  that of standard drugs.  Furthermore, triorganotin(IV) derivatives  exhibited significantly better activity than the diorganotin(IV)  derivatives.

Article Details

Synthesis, Characterization, and Biocidal Studies of the Newly Synthesized Di- and Triorganotin(IV) Complexes with n-Butylhydrogen Phthalate

Authors: Saqib ALI | Saira SHAHZADI

Publisher: TUBITAK

Main Topics: Applied physics

Journal: Turkish Journal of Chemistry 2007 Vol.31 Issue 3, pp.371-387

Document Type: Article

Publication Date: 2/2007

Document Language: English

Document ID (Org No.): 2000728728

Frequency: Bimonthly

eISSN: 1303-6130

pISSN: 1300-0527

Issues

Authors:

Saqib ALI | Saira SHAHZADI

Publisher:

TUBITAK

Main Topics:

Applied physics

Journal:

Turkish Journal of Chemistry 2007 Vol.31 Issue 3, pp.371-387

Document Type:

Article

Publication Date:

2/2007

Document Language:

English

Document ID (Org No.):

2000728728

Frequency:

Bimonthly

eISSN:

1303-6130

pISSN:

1300-0527