Effects of L-Ariginine Supplementation on Indomethacin-Induced Gastric Ulceration in Rats

Kolawole I. Ajiboye; Francis S. Oluwole; Oyebimpe F. Ajiboye

Article Details

Effects of L-Ariginine Supplementation on Indomethacin-Induced Gastric Ulceration in Rats

Authors:

Kolawole I. Ajiboye | Francis S. Oluwole | Oyebimpe F. Ajiboye

Publisher:

Zainab Arabian Research Society for Multidisciplinary Issues ( ZARSMI )

Main Topics:

Medicine

Journal:

Journal of Research and Development 2014 vol.1 Issue 8, pp.8-16

Document Type:

Article

Publication Date:

2/2014

Document Language:

English

Document ID (Org No.):

54709

Frequency:

Monthly

pISSN:

23113278

Descriptors:

Keywords:

Abstract:

 Over the last decade emphasis on therapeutic measures has shifted from curative medicine topreventive medicine. In the domain of ulcer and its treatment, not much can be said to have beenachieved in terms of preventing ulcer. Most therapies to date have focused on isolating andtreating the aggressive factor(s) responsible for the ulcer. A major find and current trend in ulcermanagement now is the role of nitric oxide (NO) and its agonists such as L-Arginine inameliorating gastric ulcers. The current study focuses on the possible effects of L-Argininesupplementation on indomethacin-induced gastric ulcerations in rats.Male Wistar albino rats weighing between 150-180g were used for the study. Animals weredivided according to the following experimental groups: Group I (Control) – saline, 8ml/kg,Group II- L-Arginine 1g/kg B.W for 3 days, Group III- L-Arginine 1g/kg B.W for 7 days.Studies carried out included the effect of L-arginine supplementation on indomethacin-inducedgastric ulcerations; determination of ulcer dimensions (area, depth and width) and histologicalprofile of the gastric mucosa.The result showed that arginine supplementation possesses capabilities of reducing ulcerformation in indomethacin-induced rats. Arginine supplementation has an ulcer reducing effectas evident by the lower ulcer scores of the supplemented groups when compared with theControl. The 3-day supplemented group had a significantly lower ulcer score (p<0.05). Ulcerarea and width were significantly reduced in the 3-day supplemented group (p<0.05) while theulcer depth was significantly reduced in both supplemented groups (p<0.01). Histologicalexamination of the gastric tissues showed that the 3-day supplemented group had greaterreduction in the level of gastric disturbance than both Control group and the 7-day supplementedgroup. We proposed that a rapid angiogenetic activity in response to arginine supplementationwhich then wanes over time may be responsible for this pattern. This study provides evidencethat arginine supplementation is beneficial in reducing the risk of gastric ulcer induced byNSAIDS and this is possibly mediated by direct enhancement of angiogenetic activity around thedisturbed gastrum.

Article Details

Effects of L-Ariginine Supplementation on Indomethacin-Induced Gastric Ulceration in Rats

Authors:

Kolawole I. Ajiboye | Francis S. Oluwole | Oyebimpe F. Ajiboye

Publisher:

Zainab Arabian Research Society for Multidisciplinary Issues ( ZARSMI )

Main Topics:

Medicine

Journal:

Journal of Research and Development 2014 vol.1 Issue 8, pp.8-16

Document Type:

Article

Publication Date:

2/2014

Document Language:

English

Document ID (Org No.):

54709

Frequency:

Monthly

pISSN:

23113278

Descriptors:

ARGININE

PEPTIC ULCERS

GASTRIC DAMAGE

ACIDITY

NITRIC OXIDE

THERAPY

GASTROINTESTINAL DISEASES

Arginine

Gastric Ulcer

Nitric Oxide

cGMP

Ulcer

Issues

Article Details

Authors: Kolawole I. Ajiboye | Francis S. Oluwole | Oyebimpe F. Ajiboye

Publisher: Zainab Arabian Research Society for Multidisciplinary Issues ( ZARSMI )

Main Topics: Medicine

Journal: Journal of Research and Development 2014 vol.1 Issue 8, pp.8-16

Document Type: Article

Publication Date: 2/2014

Document Language: English

Document ID (Org No.): 54709

Frequency: Monthly

pISSN: 23113278

Descriptors:

Issues

Authors:

Kolawole I. Ajiboye | Francis S. Oluwole | Oyebimpe F. Ajiboye

Publisher:

Zainab Arabian Research Society for Multidisciplinary Issues ( ZARSMI )

Main Topics:

Medicine

Journal:

Journal of Research and Development 2014 vol.1 Issue 8, pp.8-16

Document Type:

Article

Publication Date:

2/2014

Document Language:

English

Document ID (Org No.):

54709

Frequency:

Monthly

pISSN:

23113278