Green Synthesis : Crystal Structure and Bioactivity of C-(Psubstituted Phenyl) Calix[4] Resorcinarenes-Dmso Inclusion Complexes

Solhe F. Alshahateeta; Salah A. Al-Trawneh; Wael A. Al-Zereini; Saad S. Al-Sarhan

doi:10.12816/0026399

Article Details

Green Synthesis : Crystal Structure and Bioactivity of C-(Psubstituted Phenyl) Calix[4] Resorcinarenes-Dmso Inclusion Complexes

Authors:

Solhe F. Alshahateeta | Salah A. Al-Trawneh | Wael A. Al-Zereini | Saad S. Al-Sarhan

Publisher:

Yarmouk University : The Deanship of Research and Graduate Studies

Main Topics:

Chemistry and allied sciences

Journal:

Jordan Journal of Chemistry 2014 Vol.9 Issue 3, pp.170-186

Document Type:

Article

Publication Date:

9/2014

Document Language:

English

Document ID (Org No.):

86937

Frequency:

Quarterly

pISSN:

18149111

DOI:

10.12816/0026399

Descriptors:

Keywords:

Abstract:

 Green synthesis of calix[4]resorcinarene hosts with p-substituted phenyl group at their methine carbons was achieved. Fluorine, chlorine and bromine atoms, as well as methoxygroup, were selected as substituents at the para position of the benzaldehyde which wascondensed with resorcinol in presence of solid p-toluenesulfonic acid. The solid state structuresof the newly prepared C-(p-fluorophenyl)calix[4]resorcinarene-DMSO and C-(p-chlorophenyl)-calix[4]resorcinarene-DMSO inclusion complexes were determined by single-crystal X-raydiffraction and found to form different structural conformations; chair (C2h) and boat (C2v),respectively. In addition, both crystal structures adopted several intermolecular noncovalentsupramolecular interactions which were carefully investigated and presented in terms of crystalengineering and supramolecular chemistry. The synthesized C-(p-substitutedphenyl)calix[4]-resorcinarene hosts inhibited the growth of Gram-positive bacteria with the C-(p-bromophenyl)-calix[4]resorcinarene derivative being the most potent agent (MIC=15.6-125 μg/ml).

Article Details

Green Synthesis : Crystal Structure and Bioactivity of C-(Psubstituted Phenyl) Calix[4] Resorcinarenes-Dmso Inclusion Complexes

Authors:

Solhe F. Alshahateeta | Salah A. Al-Trawneh | Wael A. Al-Zereini | Saad S. Al-Sarhan

Publisher:

Yarmouk University : The Deanship of Research and Graduate Studies

Main Topics:

Chemistry and allied sciences

Journal:

Jordan Journal of Chemistry 2014 Vol.9 Issue 3, pp.170-186

Document Type:

Article

Publication Date:

9/2014

Document Language:

English

Document ID (Org No.):

86937

Frequency:

Quarterly

pISSN:

18149111

DOI:

10.12816/0026399

Descriptors:

BIOCHEMISTRY

LIGASES

BIOCHEMICAL REACTIONS

CHEMICAL COMPOUNDS

C-(P-Substituted Phenyl) Calix[4] Resorcinarenes-DMSO Inclusion Complex

Boat Conformation

Chair Conformation

Crystal Structure

Bioactivity

Non-Covalent Interactions

Issues

Article Details

Authors: Solhe F. Alshahateeta | Salah A. Al-Trawneh | Wael A. Al-Zereini | Saad S. Al-Sarhan

Publisher: Yarmouk University : The Deanship of Research and Graduate Studies

Main Topics: Chemistry and allied sciences

Journal: Jordan Journal of Chemistry 2014 Vol.9 Issue 3, pp.170-186

Document Type: Article

Publication Date: 9/2014

Document Language: English

Document ID (Org No.): 86937

Frequency: Quarterly

pISSN: 18149111

DOI: 10.12816/0026399

Descriptors:

Issues

Authors:

Solhe F. Alshahateeta | Salah A. Al-Trawneh | Wael A. Al-Zereini | Saad S. Al-Sarhan

Publisher:

Yarmouk University : The Deanship of Research and Graduate Studies

Main Topics:

Chemistry and allied sciences

Journal:

Jordan Journal of Chemistry 2014 Vol.9 Issue 3, pp.170-186

Document Type:

Article

Publication Date:

9/2014

Document Language:

English

Document ID (Org No.):

86937

Frequency:

Quarterly

pISSN:

18149111

DOI:

10.12816/0026399