Niacin: Does It affect 8-hydroxy-2-deoxyguanosine levels of the patients having low HDL cholesterol levels?

Ece HARMAN; Serkan AKCAY; Yankı BUKE; Hakan ER

doi:https://doi.org/10.5455/medscience.2013.02.8060

Article Details

Niacin: Does It affect 8-hydroxy-2-deoxyguanosine levels of the patients having low HDL cholesterol levels?

Authors:

Ece HARMAN | Serkan AKCAY | Yankı BUKE | Hakan ER

Publisher:

Inonu University

Journal:

Medicine Science 2013 Vol.2 Issue 2, pp.618-623

Document Type:

Article

Publication Date:

5/2013

Document Language:

Turkish

Document ID (Org No.):

2000828734

Frequency:

Quarterly

eISSN:

2147-0634

pISSN:

2147-0634

DOI:

https://doi.org/10.5455/medscience.2013.02.8060

Abstract:

 

We aimed to determine whether niacin improve plasma HDL-cholesterol levels by decreasing 8-Hydroxydeoxyguanosıne (8-OHdG) as a biomarker of oxidative DNA damage or not. Patients (n=32) with low HDL-cholesterol levels (40 mg/dl) were included in the study. Lipoprotein profiles (total cholesterol, HDL-C, and total triglycerides) were measured in all patients. LDL-C was calculated as described by Friedewald et al. Before and after 16 week of niacin therapy serum 8-OHdG was measured. There were significant difference between pre and post treatment plasma HDL-C and 8-OHdG levels. We concluded that niacin may raise HDL-C levels. The improvement of plasma HDL-C levels may have a protective effect on endothelial dysfunction. By reducing the level of 8-OHdG, niacin may decrease DNA damage. Thus, niacin therapy may be consider as an alternative to statins or fibrates in patients in whom fail to sufficiently correct low HDL-C levels. .

Article Details

Niacin: Does It affect 8-hydroxy-2-deoxyguanosine levels of the patients having low HDL cholesterol levels?

Authors: Ece HARMAN | Serkan AKCAY | Yankı BUKE | Hakan ER

Publisher: Inonu University

Journal: Medicine Science 2013 Vol.2 Issue 2, pp.618-623

Document Type: Article

Publication Date: 5/2013

Document Language: Turkish

Document ID (Org No.): 2000828734

Frequency: Quarterly

eISSN: 2147-0634

pISSN: 2147-0634

DOI: https://doi.org/10.5455/medscience.2013.02.8060

Issues

Authors:

Ece HARMAN | Serkan AKCAY | Yankı BUKE | Hakan ER

Publisher:

Inonu University

Journal:

Medicine Science 2013 Vol.2 Issue 2, pp.618-623

Document Type:

Article

Publication Date:

5/2013

Document Language:

Turkish

Document ID (Org No.):

2000828734

Frequency:

Quarterly

eISSN:

2147-0634

pISSN:

2147-0634

DOI:

https://doi.org/10.5455/medscience.2013.02.8060