Characterization of modified sorghum starch and ıts use as a film-forming polymer in orally dissolving film formulation with glycerol as a plasticizer

N.A.

Article Details

Characterization of modified sorghum starch and ıts use as a film-forming polymer in orally dissolving film formulation with glycerol as a plasticizer

Authors:

N.A.

Publisher:

Marmara University

Main Topics:

Pharmacology and Pharmaceutical Sciences (Other)

Journal:

Journal of Research in Pharmacy Vol.27 Issue 5, pp.1855-1865

Document Type:

Article

Publication Date:

6/2025

Document Language:

English

Document ID (Org No.):

2001346778

pISSN:

2630-6344

Keywords:

Abstract:

 Film-forming polymers and plasticizers are components of orally dissolving film ODF compositions that have the greatest influence on the physical properties of the film preparations. Modification of sorghum starch produces maltodextrin MDX-sorghum which can be used as a film-forming polymer, and glycerol can be used as a plasticizer in ODF preparations. This study aims to determine the optimal concentrations of MDX-sorghum and glycerol to produce ODF compositions using the central composite design CCD in response surface methodology RSM. Hydrolysis of sorghum starch yielded MDX-sorghum, characterized by yield value, dextrose equivalent DE value, solubility, swelling power and FTIR analysis. The CCD included a concentration range of 2-6 and 3-10 for MDX-sorghum and glycerol, respectively, as parameters in the optimization process, so 14 experimental designs were obtained. The test response was evaluated using tensile strength, elongation and disintegration time tests. The modification of sorghum starch yields a light brown MDX-sorghum powder with desirable properties. Optimization of MDX-sorghum and glycerol concentrations yielded an optimal formulation with a tensile value of 1.50 mPa with an error percentage of 0.33, elongation of 104.26 with an error percentage of 0.25, and disintegration time of 82.95 seconds with an error percentage of 0.06. By modifying sorghum starch into MDX-sorghum, the starchs ability to dissolve and swell can be improved, allowing it to be used as a film-forming polymer. The optimal MDX-Sorghum and glycerol concentrations for the production of ODF are 3.56 and 10.00 , respectively.

 Film-forming polymers and plasticizers are components of orally dissolving film ODF compositions that have the greatest influence on the physical properties of the film preparations. Modification of sorghum starch produces maltodextrin MDX-sorghum which can be used as a film-forming polymer, and glycerol can be used as a plasticizer in ODF preparations. This study aims to determine the optimal concentrations of MDX-sorghum and glycerol to produce ODF compositions using the central composite design CCD in response surface methodology RSM. Hydrolysis of sorghum starch yielded MDX-sorghum, characterized by yield value, dextrose equivalent DE value, solubility, swelling power and FTIR analysis. The CCD included a concentration range of 2-6 and 3-10 for MDX-sorghum and glycerol, respectively, as parameters in the optimization process, so 14 experimental designs were obtained. The test response was evaluated using tensile strength, elongation and disintegration time tests. The modification of sorghum starch yields a light brown MDX-sorghum powder with desirable properties. Optimization of MDX-sorghum and glycerol concentrations yielded an optimal formulation with a tensile value of 1.50 mPa with an error percentage of 0.33, elongation of 104.26 with an error percentage of 0.25, and disintegration time of 82.95 seconds with an error percentage of 0.06. By modifying sorghum starch into MDX-sorghum, the starchs ability to dissolve and swell can be improved, allowing it to be used as a film-forming polymer. The optimal MDX-Sorghum and glycerol concentrations for the production of ODF are 3.56 and 10.00 , respectively.

 Film-forming polymers and plasticizers are components of orally dissolving film ODF compositions that have the greatest influence on the physical properties of the film preparations. Modification of sorghum starch produces maltodextrin MDX-sorghum which can be used as a film-forming polymer, and glycerol can be used as a plasticizer in ODF preparations. This study aims to determine the optimal concentrations of MDX-sorghum and glycerol to produce ODF compositions using the central composite design CCD in response surface methodology RSM. Hydrolysis of sorghum starch yielded MDX-sorghum, characterized by yield value, dextrose equivalent DE value, solubility, swelling power and FTIR analysis. The CCD included a concentration range of 2-6 and 3-10 for MDX-sorghum and glycerol, respectively, as parameters in the optimization process, so 14 experimental designs were obtained. The test response was evaluated using tensile strength, elongation and disintegration time tests. The modification of sorghum starch yields a light brown MDX-sorghum powder with desirable properties. Optimization of MDX-sorghum and glycerol concentrations yielded an optimal formulation with a tensile value of 1.50 mPa with an error percentage of 0.33, elongation of 104.26 with an error percentage of 0.25, and disintegration time of 82.95 seconds with an error percentage of 0.06. By modifying sorghum starch into MDX-sorghum, the starchs ability to dissolve and swell can be improved, allowing it to be used as a film-forming polymer. The optimal MDX-Sorghum and glycerol concentrations for the production of ODF are 3.56 and 10.00 , respectively.

 Film-forming polymers and plasticizers are components of orally dissolving film ODF compositions that have the greatest influence on the physical properties of the film preparations. Modification of sorghum starch produces maltodextrin MDX-sorghum which can be used as a film-forming polymer, and glycerol can be used as a plasticizer in ODF preparations. This study aims to determine the optimal concentrations of MDX-sorghum and glycerol to produce ODF compositions using the central composite design CCD in response surface methodology RSM. Hydrolysis of sorghum starch yielded MDX-sorghum, characterized by yield value, dextrose equivalent DE value, solubility, swelling power and FTIR analysis. The CCD included a concentration range of 2-6 and 3-10 for MDX-sorghum and glycerol, respectively, as parameters in the optimization process, so 14 experimental designs were obtained. The test response was evaluated using tensile strength, elongation and disintegration time tests. The modification of sorghum starch yields a light brown MDX-sorghum powder with desirable properties. Optimization of MDX-sorghum and glycerol concentrations yielded an optimal formulation with a tensile value of 1.50 mPa with an error percentage of 0.33, elongation of 104.26 with an error percentage of 0.25, and disintegration time of 82.95 seconds with an error percentage of 0.06. By modifying sorghum starch into MDX-sorghum, the starchs ability to dissolve and swell can be improved, allowing it to be used as a film-forming polymer. The optimal MDX-Sorghum and glycerol concentrations for the production of ODF are 3.56 and 10.00 , respectively.

Article Details

Characterization of modified sorghum starch and ıts use as a film-forming polymer in orally dissolving film formulation with glycerol as a plasticizer

Authors:

N.A.

Publisher:

Marmara University

Main Topics:

Pharmacology and Pharmaceutical Sciences (Other)

Journal:

Journal of Research in Pharmacy Vol.27 Issue 5, pp.1855-1865

Document Type:

Article

Publication Date:

6/2025

Document Language:

English

Document ID (Org No.):

2001346778

pISSN:

2630-6344

Sorghum strach

modified

film-forming

glycerol

response surface methodology.

Issues

Article Details

Characterization of modified sorghum starch and ıts use as a film-forming polymer in orally dissolving film formulation with glycerol as a plasticizer

Authors: N.A.

Publisher: Marmara University

Main Topics: Pharmacology and Pharmaceutical Sciences (Other)

Journal: Journal of Research in Pharmacy Vol.27 Issue 5, pp.1855-1865

Document Type: Article

Publication Date: 6/2025

Document Language: English

Document ID (Org No.): 2001346778

pISSN: 2630-6344

Sorghum strach

modified

film-forming

glycerol

response surface methodology.

Issues

Authors:

N.A.

Publisher:

Marmara University

Main Topics:

Pharmacology and Pharmaceutical Sciences (Other)

Journal:

Journal of Research in Pharmacy Vol.27 Issue 5, pp.1855-1865

Document Type:

Article

Publication Date:

6/2025

Document Language:

English

Document ID (Org No.):

2001346778

pISSN:

2630-6344