A Gene Expression Study of the TGF-b Signaling Pathway Components in Differentiating PC12 Cells

Işıl AKSAN KURNAZ

Article Details

A Gene Expression Study of the TGF-b Signaling Pathway Components in Differentiating PC12 Cells

Authors:

Işıl AKSAN KURNAZ

Publisher:

TUBITAK

Journal:

Turkish Journal of Biology 2005 Vol.29 Issue 4, pp.189-195

Document Type:

Article

Publication Date:

3/2005

Document Language:

Turkish

Document ID (Org No.):

2000813430

Frequency:

Bimonthly

eISSN:

1303-6092

pISSN:

1300-0152

Keywords:

Abstract:

 

The neuronal differentiation process has been studied in great detail from many aspects. In the PC12 system, NGF was found to induce neuronal differentiation as measured by neurite extensions and neuronal marker expression. This effect was seen to be mainly conducted through the Ras/MAPK pathway; however, additional pathways are suspected to play a significant role in this cellular response. One such pathway is Smad signaling - NGF was previously reported to induce the expression of the TGF-b signal, although the physiological relevance of this was not completely understood. In this study, we analyzed the expression profiles of several TGF-b pathway components, in an attempt to understand the potential role of this pathway in NGF-induced differentiation of PC12 cells.

 

The neuronal differentiation process has been studied in great detail from many aspects. In the PC12 system, NGF was found to induce neuronal differentiation as measured by neurite extensions and neuronal marker expression. This effect was seen to be mainly conducted through the Ras/MAPK pathway; however, additional pathways are suspected to play a significant role in this cellular response. One such pathway is Smad signaling - NGF was previously reported to induce the expression of the TGF-b signal, although the physiological relevance of this was not completely understood. In this study, we analyzed the expression profiles of several TGF-b pathway components, in an attempt to understand the potential role of this pathway in NGF-induced differentiation of PC12 cells.

Article Details

A Gene Expression Study of the TGF-b Signaling Pathway Components in Differentiating PC12 Cells

Authors:

Işıl AKSAN KURNAZ

Publisher:

TUBITAK

Journal:

Turkish Journal of Biology 2005 Vol.29 Issue 4, pp.189-195

Document Type:

Article

Publication Date:

3/2005

Document Language:

Turkish

Document ID (Org No.):

2000813430

Frequency:

Bimonthly

eISSN:

1303-6092

pISSN:

1300-0152

PC12

TGF-b

Smad

NGF

gene expression profiling

neuronal differentiation

Issues

Article Details

A Gene Expression Study of the TGF-b Signaling Pathway Components in Differentiating PC12 Cells

Authors: Işıl AKSAN KURNAZ

Publisher: TUBITAK

Journal: Turkish Journal of Biology 2005 Vol.29 Issue 4, pp.189-195

Document Type: Article

Publication Date: 3/2005

Document Language: Turkish

Document ID (Org No.): 2000813430

Frequency: Bimonthly

eISSN: 1303-6092

pISSN: 1300-0152

PC12

TGF-b

Smad

NGF

gene expression profiling

neuronal differentiation

Issues

Authors:

Işıl AKSAN KURNAZ

Publisher:

TUBITAK

Journal:

Turkish Journal of Biology 2005 Vol.29 Issue 4, pp.189-195

Document Type:

Article

Publication Date:

3/2005

Document Language:

Turkish

Document ID (Org No.):

2000813430

Frequency:

Bimonthly

eISSN:

1303-6092

pISSN:

1300-0152