Evaluation of anti-diabetic potential of Ficus arnottiana Miq. leaves against in-vivo and in-vitro experimental models of diabetes

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Article Details

Evaluation of anti-diabetic potential of Ficus arnottiana Miq. leaves against in-vivo and in-vitro experimental models of diabetes

Authors:

N.A.

Publisher:

Marmara University

Main Topics:

Pharmacology and Pharmaceutical Sciences (Other)

Journal:

Journal of Research in Pharmacy Vol.28 Issue 5, pp.1844-1854

Document Type:

Article

Publication Date:

6/2025

Document Language:

English

Document ID (Org No.):

2001347604

pISSN:

2630-6344

Keywords:

Abstract:

 The present study was aimed to investigate the potential anti-diabetic effects of Ficus arnottiana Miq. leaves against streptozotocin-induced diabetic model in experimental animals. The leaves of Ficus arnottiana were collected and processed into a powdered form, which was subsequently extracted using methanol as the solvent. The anti-diabetic activity of the resulting extract was evaluated at two oral doses 200 and 400 mgkg at two different doses 200 and 400 mgkg. The parameters assessed in this study included blood glucose levels, C-peptide levels, and serum insulin levels. Furthermore, pancreatic tissue samples were subjected to histopathological analysis. Additionally, in vitro determination of -amylase and -glucosidase inhibition by the extract was carried out. The phytochemical screening of the extract revealed the presence of alkaloids, tannins, flavonoids, phenolic compounds, reducing sugars, and saponins. For anti-diabetic activity, the test extract significantly reduced blood glucose levels while increasing both serum C-peptide and serum insulin levels. Histopathological analysis of extract treated group depicted improved islets of Langerhans and an increase in centrally located beta cells. Furthermore, the extract significantly inhibited -amylase and - glucosidase enzyme in-vitro. Based on these findings, it can be concluded that Ficus arnottiana Miq leaves extract exhibits antidiabetic activity. And the anti-diabetic effect of Ficus arnottiana Miq at 400 mgkg was comparable to that of the standard drugs Glibenclamide in-vivo and acarbose in-vitro.

 The present study was aimed to investigate the potential anti-diabetic effects of Ficus arnottiana Miq. leaves against streptozotocin-induced diabetic model in experimental animals. The leaves of Ficus arnottiana were collected and processed into a powdered form, which was subsequently extracted using methanol as the solvent. The anti-diabetic activity of the resulting extract was evaluated at two oral doses 200 and 400 mgkg at two different doses 200 and 400 mgkg. The parameters assessed in this study included blood glucose levels, C-peptide levels, and serum insulin levels. Furthermore, pancreatic tissue samples were subjected to histopathological analysis. Additionally, in vitro determination of -amylase and -glucosidase inhibition by the extract was carried out. The phytochemical screening of the extract revealed the presence of alkaloids, tannins, flavonoids, phenolic compounds, reducing sugars, and saponins. For anti-diabetic activity, the test extract significantly reduced blood glucose levels while increasing both serum C-peptide and serum insulin levels. Histopathological analysis of extract treated group depicted improved islets of Langerhans and an increase in centrally located beta cells. Furthermore, the extract significantly inhibited -amylase and - glucosidase enzyme in-vitro. Based on these findings, it can be concluded that Ficus arnottiana Miq leaves extract exhibits antidiabetic activity. And the anti-diabetic effect of Ficus arnottiana Miq at 400 mgkg was comparable to that of the standard drugs Glibenclamide in-vivo and acarbose in-vitro.

 The present study was aimed to investigate the potential anti-diabetic effects of Ficus arnottiana Miq. leaves against streptozotocin-induced diabetic model in experimental animals. The leaves of Ficus arnottiana were collected and processed into a powdered form, which was subsequently extracted using methanol as the solvent. The anti-diabetic activity of the resulting extract was evaluated at two oral doses 200 and 400 mgkg at two different doses 200 and 400 mgkg. The parameters assessed in this study included blood glucose levels, C-peptide levels, and serum insulin levels. Furthermore, pancreatic tissue samples were subjected to histopathological analysis. Additionally, in vitro determination of -amylase and -glucosidase inhibition by the extract was carried out. The phytochemical screening of the extract revealed the presence of alkaloids, tannins, flavonoids, phenolic compounds, reducing sugars, and saponins. For anti-diabetic activity, the test extract significantly reduced blood glucose levels while increasing both serum C-peptide and serum insulin levels. Histopathological analysis of extract treated group depicted improved islets of Langerhans and an increase in centrally located beta cells. Furthermore, the extract significantly inhibited -amylase and - glucosidase enzyme in-vitro. Based on these findings, it can be concluded that Ficus arnottiana Miq leaves extract exhibits antidiabetic activity. And the anti-diabetic effect of Ficus arnottiana Miq at 400 mgkg was comparable to that of the standard drugs Glibenclamide in-vivo and acarbose in-vitro.

 The present study was aimed to investigate the potential anti-diabetic effects of Ficus arnottiana Miq. leaves against streptozotocin-induced diabetic model in experimental animals. The leaves of Ficus arnottiana were collected and processed into a powdered form, which was subsequently extracted using methanol as the solvent. The anti-diabetic activity of the resulting extract was evaluated at two oral doses 200 and 400 mgkg at two different doses 200 and 400 mgkg. The parameters assessed in this study included blood glucose levels, C-peptide levels, and serum insulin levels. Furthermore, pancreatic tissue samples were subjected to histopathological analysis. Additionally, in vitro determination of -amylase and -glucosidase inhibition by the extract was carried out. The phytochemical screening of the extract revealed the presence of alkaloids, tannins, flavonoids, phenolic compounds, reducing sugars, and saponins. For anti-diabetic activity, the test extract significantly reduced blood glucose levels while increasing both serum C-peptide and serum insulin levels. Histopathological analysis of extract treated group depicted improved islets of Langerhans and an increase in centrally located beta cells. Furthermore, the extract significantly inhibited -amylase and - glucosidase enzyme in-vitro. Based on these findings, it can be concluded that Ficus arnottiana Miq leaves extract exhibits antidiabetic activity. And the anti-diabetic effect of Ficus arnottiana Miq at 400 mgkg was comparable to that of the standard drugs Glibenclamide in-vivo and acarbose in-vitro.

Article Details

Evaluation of anti-diabetic potential of Ficus arnottiana Miq. leaves against in-vivo and in-vitro experimental models of diabetes

Authors:

N.A.

Publisher:

Marmara University

Main Topics:

Pharmacology and Pharmaceutical Sciences (Other)

Journal:

Journal of Research in Pharmacy Vol.28 Issue 5, pp.1844-1854

Document Type:

Article

Publication Date:

6/2025

Document Language:

English

Document ID (Org No.):

2001347604

pISSN:

2630-6344

Anti-diabetic activity

STZ induced diabetes

histopathological evaluation

α-amylase

α- glucosidase

Ficus arnottiana (Miq)

Issues

Article Details

Evaluation of anti-diabetic potential of Ficus arnottiana Miq. leaves against in-vivo and in-vitro experimental models of diabetes

Authors: N.A.

Publisher: Marmara University

Main Topics: Pharmacology and Pharmaceutical Sciences (Other)

Journal: Journal of Research in Pharmacy Vol.28 Issue 5, pp.1844-1854

Document Type: Article

Publication Date: 6/2025

Document Language: English

Document ID (Org No.): 2001347604

pISSN: 2630-6344

Anti-diabetic activity

STZ induced diabetes

histopathological evaluation

α-amylase

α- glucosidase

Ficus arnottiana (Miq)

Issues

Authors:

N.A.

Publisher:

Marmara University

Main Topics:

Pharmacology and Pharmaceutical Sciences (Other)

Journal:

Journal of Research in Pharmacy Vol.28 Issue 5, pp.1844-1854

Document Type:

Article

Publication Date:

6/2025

Document Language:

English

Document ID (Org No.):

2001347604

pISSN:

2630-6344