Effect of Vitamin C on Oxidant and Antioxidant Parameters in Cattle Immunized by Blackleg Vaccine

Ertan Doğan; Oğuz Merhan; Hale Ergin Eğritağ; Kadir Bozukluhan; Dinçer Erdağ

Article Details

Effect of Vitamin C on Oxidant and Antioxidant Parameters in Cattle Immunized by Blackleg Vaccine

Authors:

Ertan Doğan | Oğuz Merhan | Hale Ergin Eğritağ | Kadir Bozukluhan | Dinçer Erdağ

Publisher:

Aydin Adnan Menderes University

Main Topics:

Veteriner Bilimleri

Journal:

Animal Health Production and Hygiene Vol.12 Issue 2, pp.7-12

Document Type:

Article

Publication Date:

12/2023

Document Language:

English

Document ID (Org No.):

2001306488

pISSN:

2146-7269

Keywords:

Abstract:

 The goal of this study is to determine the effect of vitamin c on certain oxidant and antioxidant parameters in cattle immunized against blackleg. In the study, a total of 40 cattle aged 12 to 18 months, of different breeds and genders, were used in the Ardahan region. The cattle were divided into four equal groups. The Control group received 2 ml of saline, the Vitamin group received 5 mgkg dose of vitamin c, the Vaccine-Vitamin group received 2 ml of blackleg vaccine and 5mgkg vitamin c, and the Vaccine group received 2 ml of blackleg vaccine. Blood samples were taken from all animals before vaccination day 0 and on the 2nd, 14th, and 28th days of administration. On the 2nd, 14th, and 28th days, malondialdehyde MDA and nitric oxide NO levels were substantially increased P0.05 in the Vaccine group compared to the Control and Vitamin groups, while superoxide dismutase SOD and catalase CAT levels were considerably decreased P0.05. It was noted that the amount of MDA and NO measured in the 2nd, 14th, and 28th days in the Vaccine-Vitamin group reduced compared to the Vaccine group, while the amount of SOD and CAT enhanced. The study concluded that the blackleg vaccine administered to cattle causes oxidative stress and lipid peroxidation, and that vitamin c acts as an antioxidant. Vitamin c administration with blackleg vaccine in cattle is believed to be beneficial for lowering oxidative stress.

 The goal of this study is to determine the effect of vitamin c on certain oxidant and antioxidant parameters in cattle immunized against blackleg. In the study, a total of 40 cattle aged 12 to 18 months, of different breeds and genders, were used in the Ardahan region. The cattle were divided into four equal groups. The Control group received 2 ml of saline, the Vitamin group received 5 mgkg dose of vitamin c, the Vaccine-Vitamin group received 2 ml of blackleg vaccine and 5mgkg vitamin c, and the Vaccine group received 2 ml of blackleg vaccine. Blood samples were taken from all animals before vaccination day 0 and on the 2nd, 14th, and 28th days of administration. On the 2nd, 14th, and 28th days, malondialdehyde MDA and nitric oxide NO levels were substantially increased P0.05 in the Vaccine group compared to the Control and Vitamin groups, while superoxide dismutase SOD and catalase CAT levels were considerably decreased P0.05. It was noted that the amount of MDA and NO measured in the 2nd, 14th, and 28th days in the Vaccine-Vitamin group reduced compared to the Vaccine group, while the amount of SOD and CAT enhanced. The study concluded that the blackleg vaccine administered to cattle causes oxidative stress and lipid peroxidation, and that vitamin c acts as an antioxidant. Vitamin c administration with blackleg vaccine in cattle is believed to be beneficial for lowering oxidative stress.

 The goal of this study is to determine the effect of vitamin c on certain oxidant and antioxidant parameters in cattle immunized against blackleg. In the study, a total of 40 cattle aged 12 to 18 months, of different breeds and genders, were used in the Ardahan region. The cattle were divided into four equal groups. The Control group received 2 ml of saline, the Vitamin group received 5 mgkg dose of vitamin c, the Vaccine-Vitamin group received 2 ml of blackleg vaccine and 5mgkg vitamin c, and the Vaccine group received 2 ml of blackleg vaccine. Blood samples were taken from all animals before vaccination day 0 and on the 2nd, 14th, and 28th days of administration. On the 2nd, 14th, and 28th days, malondialdehyde MDA and nitric oxide NO levels were substantially increased P0.05 in the Vaccine group compared to the Control and Vitamin groups, while superoxide dismutase SOD and catalase CAT levels were considerably decreased P0.05. It was noted that the amount of MDA and NO measured in the 2nd, 14th, and 28th days in the Vaccine-Vitamin group reduced compared to the Vaccine group, while the amount of SOD and CAT enhanced. The study concluded that the blackleg vaccine administered to cattle causes oxidative stress and lipid peroxidation, and that vitamin c acts as an antioxidant. Vitamin c administration with blackleg vaccine in cattle is believed to be beneficial for lowering oxidative stress.

 Bu araştırmanın amacı Yanıkara aşısı ile aşılanan sığırlarda c vitamininin bazı oksidan ve antioksidan parametreler üzerine etkisini belirlemektir. Araştırmada, Ardahan yöresinde ırk ve cinsiyetleri farklı, 12-18 aylık toplam 40 sığır kullanıldı. Sığırlar dört eşit gruba ayrıldı. Kontrol grubuna 2 ml serum fizyolojik, Vitamin grubuna 5 mgkg dozda c vitamini, Aşı-Vitamin grubuna 2 ml yanıkara aşısı ve 5mgkg c vitamini, Aşı grubuna ise 2 ml yanıkara aşısı enjekte edildi. Aşı ve ilaç uygulaması öncesinde 0.gün ve uygulamanın 2. 14. ve 28. gününde tüm hayvanlardan kan örnekleri alındı. Uygulamanın 2.14. ve 28. gününde Aşı grubunda malondialdehit MDA ve nitrik oksit NO düzeyinin Kontrol ve Vitamin grubuna göre anlamlı oranda P0.05 arttığı, süperoksit dismutaz SOD ve katalaz CAT düzeylerinin ise anlamlı oranda P0.05 azaldığı görüldü. Aşı-Vitamin grubunda 2.14. ve 28. gün ölçülen MDA ve NO miktarının Aşı grubuna göre düştüğü, SOD ve CAT miktarının ise yükseldiği görüldü. Bu araştırmada, sığırlara uygulanan yanıkara aşısının oksidatif strese ve lipid peroksidasyonuna neden olduğu ve c vitamininin antioksidan etki gösterdiği sonucuna varıldı. Sığırlarda yanıkara aşısı ile birlikte c vitamini uygulamasının oksidatif stresi azaltma açısından faydalı olacağı düşünülmektedir.

Article Details

Effect of Vitamin C on Oxidant and Antioxidant Parameters in Cattle Immunized by Blackleg Vaccine

Authors:

Ertan Doğan | Oğuz Merhan | Hale Ergin Eğritağ | Kadir Bozukluhan | Dinçer Erdağ

Publisher:

Aydin Adnan Menderes University

Main Topics:

Veteriner Bilimleri

Journal:

Animal Health Production and Hygiene Vol.12 Issue 2, pp.7-12

Document Type:

Article

Publication Date:

12/2023

Document Language:

English

Document ID (Org No.):

2001306488

pISSN:

2146-7269

Blackleg vaccine

Cattle

Lipid Peroxidation

Oxidative stress

Vitamin CC vitamini

Lipid Peroksidasyonu

Oksidatif stres

Sığır

Yanıkara aşısı

Issues

Article Details

Authors: Ertan Doğan | Oğuz Merhan | Hale Ergin Eğritağ | Kadir Bozukluhan | Dinçer Erdağ

Publisher: Aydin Adnan Menderes University

Main Topics: Veteriner Bilimleri

Journal: Animal Health Production and Hygiene Vol.12 Issue 2, pp.7-12

Document Type: Article

Publication Date: 12/2023

Document Language: English

Document ID (Org No.): 2001306488

pISSN: 2146-7269

Issues

Authors:

Ertan Doğan | Oğuz Merhan | Hale Ergin Eğritağ | Kadir Bozukluhan | Dinçer Erdağ

Publisher:

Aydin Adnan Menderes University

Main Topics:

Veteriner Bilimleri

Journal:

Animal Health Production and Hygiene Vol.12 Issue 2, pp.7-12

Document Type:

Article

Publication Date:

12/2023

Document Language:

English

Document ID (Org No.):

2001306488

pISSN:

2146-7269