Enhanced Susceptibility to in Vitro Oxidation of Apolipoprotein B-Containing Lipoproteins and Antioxidant Status in Patients with Coronary Artery Disease

Zehra SERDAR

Article Details

Enhanced Susceptibility to in Vitro Oxidation of Apolipoprotein B-Containing Lipoproteins and Antioxidant Status in Patients with Coronary Artery Disease

Authors:

Zehra SERDAR

Publisher:

TUBITAK

Journal:

Turkish Journal of Medical Sciences 2002 Vol.32 Issue 5, pp.379-383

Document Type:

Article

Publication Date:

4/2002

Document Language:

Turkish

Document ID (Org No.):

2000756895

Frequency:

Bimonthly

eISSN:

1303-6165

pISSN:

1300-0144

Keywords:

Abstract:

 

Lipoprotein oxidation may play a pivotal role in the pathogenesis of atherosclerosis, and vitamin E and b-carotene have been proposed to prevent the development and progression of atherosclerosis.  The aim of this study was to investigate the oxidative susceptibility of apolipoprotein B    (apo B)-containing lipoproteins and their relation with vitamin E and total carotene levels.      The susceptibility of apo B-containing lipoproteins to oxidation, plasma malondialdehyde (MDA), serum vitamin E, total carotene, lipid and lipoprotein levels were studied in 177 patients with coronary artery disease (CAD) and 75 non-CAD subjects. All subjects  (n = 252) had undergone coronary catheterization. Student's unpaired t-test, chi-square test and Pearson's correlation test were used for the statistical analyses.  CAD patients demonstrated significant decreases in serum vitamin E and total carotene levels and significant increases in low density lipoprotein-cholesterol (LDL-C) and MDA levels. D MDA (oxidizability of apo B-containing lipoproteins) was negatively correlated with vitamin E and inversely correlated with LDL-C, apo B and MDA levels in CAD patients.   In conclusion, oxidized forms of apo B-containing lipoproteins may play an important role in the pathogenesis of atherosclerosis, and antioxidant vitamin supplementation may be useful in CAD by improving the oxidative balance.

 

Lipoprotein oxidation may play a pivotal role in the pathogenesis of atherosclerosis, and vitamin E and b-carotene have been proposed to prevent the development and progression of atherosclerosis.  The aim of this study was to investigate the oxidative susceptibility of apolipoprotein B    (apo B)-containing lipoproteins and their relation with vitamin E and total carotene levels.      The susceptibility of apo B-containing lipoproteins to oxidation, plasma malondialdehyde (MDA), serum vitamin E, total carotene, lipid and lipoprotein levels were studied in 177 patients with coronary artery disease (CAD) and 75 non-CAD subjects. All subjects  (n = 252) had undergone coronary catheterization. Student's unpaired t-test, chi-square test and Pearson's correlation test were used for the statistical analyses.  CAD patients demonstrated significant decreases in serum vitamin E and total carotene levels and significant increases in low density lipoprotein-cholesterol (LDL-C) and MDA levels. D MDA (oxidizability of apo B-containing lipoproteins) was negatively correlated with vitamin E and inversely correlated with LDL-C, apo B and MDA levels in CAD patients.   In conclusion, oxidized forms of apo B-containing lipoproteins may play an important role in the pathogenesis of atherosclerosis, and antioxidant vitamin supplementation may be useful in CAD by improving the oxidative balance.

Article Details

Enhanced Susceptibility to in Vitro Oxidation of Apolipoprotein B-Containing Lipoproteins and Antioxidant Status in Patients with Coronary Artery Disease

Authors:

Zehra SERDAR

Publisher:

TUBITAK

Journal:

Turkish Journal of Medical Sciences 2002 Vol.32 Issue 5, pp.379-383

Document Type:

Article

Publication Date:

4/2002

Document Language:

Turkish

Document ID (Org No.):

2000756895

Frequency:

Bimonthly

eISSN:

1303-6165

pISSN:

1300-0144

Lipoprotein oxidation

Vitamin E

Total carotene

Coronary artery disease

Issues

Article Details

Enhanced Susceptibility to in Vitro Oxidation of Apolipoprotein B-Containing Lipoproteins and Antioxidant Status in Patients with Coronary Artery Disease

Authors: Zehra SERDAR

Publisher: TUBITAK

Journal: Turkish Journal of Medical Sciences 2002 Vol.32 Issue 5, pp.379-383

Document Type: Article

Publication Date: 4/2002

Document Language: Turkish

Document ID (Org No.): 2000756895

Frequency: Bimonthly

eISSN: 1303-6165

pISSN: 1300-0144

Lipoprotein oxidation

Vitamin E

Total carotene

Coronary artery disease

Issues

Authors:

Zehra SERDAR

Publisher:

TUBITAK

Journal:

Turkish Journal of Medical Sciences 2002 Vol.32 Issue 5, pp.379-383

Document Type:

Article

Publication Date:

4/2002

Document Language:

Turkish

Document ID (Org No.):

2000756895

Frequency:

Bimonthly

eISSN:

1303-6165

pISSN:

1300-0144