THE EFFECTS OF ACE-I AND ARB ON PERITONEAL ALBUMIN LOSS AND SERUM ALBUMIN LEVELS IN PERITONEAL DIALYSIS PATIENTS

Betül ÖĞÜTMEN; Serhan TUĞLULAR; Emel AKOĞLU; Çetin ÖZENER

Article Details

THE EFFECTS OF ACE-I AND ARB ON PERITONEAL ALBUMIN LOSS AND SERUM ALBUMIN LEVELS IN PERITONEAL DIALYSIS PATIENTS

Authors:

Betül ÖĞÜTMEN | Serhan TUĞLULAR | Emel AKOĞLU | Çetin ÖZENER

Publisher:

Marmara University

Journal:

Marmara Medical Journal 2003 Vol.16 Issue 2, pp.103-106

Document Type:

Article

Publication Date:

12/2016

Document Language:

Turkish

Document ID (Org No.):

2000546221

Frequency:

Monthly

eISSN:

1309-9469

pISSN:

1019-1941

Abstract:

 


Objective: Anti-proteinuric effects of angiotensin converting enzyme inhibitors (ACE-I) and angiotensin receptor blockers (ARB) have been established in various renal diseases. However, the effects of ACE-I and ARB on the permeability of peritoneal membrane are unknown and the effect of ACE-I and ARB use on peritoneal permeability in patients undergoing continuous ambulatory peritoneal dialysis has not been studied.Methods: Fifty non-diabetic patients with high peritoneal permeability, who had been on a regular peritoneal dialysis (PD) treatment for at least one year, were included in the study. The patients were prospectively randomized either fosinopril 10 mg/day p.o (n=25) (group 1) or valsartan 80 mg/day p.o (n=25) (group 2) for 12 months. All patients received standard 35- cal/kg/day diets with 1,2-g/kg/day protein intake and strict salt restriction. All patients were on standard PD program (2 L; 1.36%, 4exchanges/day). Annual mean serum albumin level, calculated from the monthly serum albumin level and peritoneal albumin values obtained from the dialysate after 8 hours, dwell on two occasions 6 months apart were measured twice yearly.Results: A significant increase in the serum albumin values, (3.68±0.56 g/dl vs. 3.94±0.46 g/dl, p0.05) was observed in the serum albumin values, a significant decrease (8.62±3.87 g/dl vs. 5.84±2.94 g/dl, p<0.01) was obtained in peritoneal fluid albumin values for the ARB group.Conclusion: At the end of the study a significant decrease was observed in the peritoneal protein values for patients on ACE-I and ARB.Key Words: Peritoneal dialysis, Angiotensin converting enzyme inhibitor, Angiotensin receptor blocker and albumin

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Article Details

THE EFFECTS OF ACE-I AND ARB ON PERITONEAL ALBUMIN LOSS AND SERUM ALBUMIN LEVELS IN PERITONEAL DIALYSIS PATIENTS

Authors: Betül ÖĞÜTMEN | Serhan TUĞLULAR | Emel AKOĞLU | Çetin ÖZENER

Publisher: Marmara University

Journal: Marmara Medical Journal 2003 Vol.16 Issue 2, pp.103-106

Document Type: Article

Publication Date: 12/2016

Document Language: Turkish

Document ID (Org No.): 2000546221

Frequency: Monthly

eISSN: 1309-9469

pISSN: 1019-1941

Issues

Authors:

Betül ÖĞÜTMEN | Serhan TUĞLULAR | Emel AKOĞLU | Çetin ÖZENER

Publisher:

Marmara University

Journal:

Marmara Medical Journal 2003 Vol.16 Issue 2, pp.103-106

Document Type:

Article

Publication Date:

12/2016

Document Language:

Turkish

Document ID (Org No.):

2000546221

Frequency:

Monthly

eISSN:

1309-9469

pISSN:

1019-1941