Balarist (Apis mellifera) Zehirinin, Kobayda Tansiyona ve Barsak Hareketlerine Etkisi

Orhan ALTINKURT; Melih ALTAN

doi:https://doi.org/10.1501/Eczfak_0000000421

Article Details

Balarist (Apis mellifera) Zehirinin, Kobayda Tansiyona ve Barsak Hareketlerine Etkisi

Authors:

Orhan ALTINKURT | Melih ALTAN

Publisher:

Ankara University

Journal:

Journal of Faculty of Pharmacy of Ankara University 1978 Vol.8 Issue 1, pp.40-50

Document Type:

Article

Publication Date:

5/1978

Document Language:

Turkish

Document ID (Org No.):

2000868581

Frequency:

Tri-annual

eISSN:

2564-6524

pISSN:

1015-3918

DOI:

https://doi.org/10.1501/Eczfak_0000000421

Abstract:

 

The venom extract obtained from the honeybees of the Ankara
 environment, giyen intravenously, produced a short—lived hypotension
 on the guinea—pig blood pressure. Usually the blood pressure
 was returned to its normal level in a short time. Sometimes this hypotensive
 effect was followed by a hypertension which lasted for 10
 or 15 minutes. Similar effects had been reported by several investigators
 with scorpion venom on several laboratory animals. Although
 this initial hypotensive effect produced by the scorpion venom could
 be prevented with atropine, the same effect of the bee venom could
 not be blocked with it. However, Systral antagonized this hypotensive
 effect competitively. The bee venom extract constricted the guineapig
 ileum and this action of the extract was inhibited with Antistamin.
 But this antagonism is different from the effect on the blood pressure
 as being a noncompetitive one.

 

Ankara çevresi arılarından elde edilen zehir ekstresi I.V verildiğinde
 kobay arter bas ıncında kı sa süreli hıpotansif etki olu şturmakta
 ve çoğunlukla tansiyon hemen normale dönmektedir. Bazan da bu
 hipotansif etkiyi, akrep zehirinin çe şitli laboratuvar hayvanları nda
 meydana getirdiği, önce hipotansiyon sonra hipertansiyon yapt ırı cı
 etkisindeki gibi, 10-15 dakika süren bir hipertansiyon izlemektedir.
 Akrep zehirinde atropinle giderildiği bilinen, arı zehirinde ise atropinle
 önleyemediğimiz bu hipotansif etki Systral ile kompetitif bir
 şekilde antagonize edilmektedir.
 Arı zehiri ekstresi kobay ileumunda kast ırıcı bir etki göstermekte
 ve bu etki de Antistamin ile inhibe edilmektedir. Fakat buradaki
 etki, tansiyondakinden farkl ı olarak nonkompetitifdir.

Article Details

Balarist (Apis mellifera) Zehirinin, Kobayda Tansiyona ve Barsak Hareketlerine Etkisi

Authors: Orhan ALTINKURT | Melih ALTAN

Publisher: Ankara University

Journal: Journal of Faculty of Pharmacy of Ankara University 1978 Vol.8 Issue 1, pp.40-50

Document Type: Article

Publication Date: 5/1978

Document Language: Turkish

Document ID (Org No.): 2000868581

Frequency: Tri-annual

eISSN: 2564-6524

pISSN: 1015-3918

DOI: https://doi.org/10.1501/Eczfak_0000000421

Issues

Authors:

Orhan ALTINKURT | Melih ALTAN

Publisher:

Ankara University

Journal:

Journal of Faculty of Pharmacy of Ankara University 1978 Vol.8 Issue 1, pp.40-50

Document Type:

Article

Publication Date:

5/1978

Document Language:

Turkish

Document ID (Org No.):

2000868581

Frequency:

Tri-annual

eISSN:

2564-6524

pISSN:

1015-3918

DOI:

https://doi.org/10.1501/Eczfak_0000000421