Anticholinesterase furocoumarins from Heracleum platytaenium, a species endemic to the Ida Mountains

Demet DİNCEL; Seda Damla HATİPOĞLU; Ahmet Ceyhan GÖREN

Article Details

Anticholinesterase furocoumarins from Heracleum platytaenium, a species endemic to the Ida Mountains

Authors:

Demet DİNCEL | Seda Damla HATİPOĞLU | Ahmet Ceyhan GÖREN

Publisher:

TUBITAK

Journal:

Turkish Journal of Chemistry 2013 Vol.37 Issue 4, pp.675-683

Document Type:

Article

Publication Date:

3/2013

Document Language:

Turkish

Document ID (Org No.):

2000727398

Frequency:

Bimonthly

eISSN:

1303-6130

pISSN:

1300-0527

Abstract:

 

The petroleum ether extract of Heracleum platytaenium afforded 8 furocoumarins   (psoralen, bergapten, xanthotoxin, pimpinellin, isopimpinellin, sphondin,   byakangelicin, and heraclenol) and the methanol extract of H. platytaenium gave only 1   glycosylated dihydrofurocoumarin, apterin. In addition, stigmasterol was   also obtained from petroleum ether extract. Structure identification of the   isolated compounds has been achieved by using spectroscopic methods, namely   1D and 2D NMR experiments and mass spectral analyses. The antioxidant   activity of the extracts and pure compounds was investigated by 2 methods,   including DPPH free radical scavenging activity and lipid peroxidation   inhibitory activity by b-carotene-linoleic acid assays. The   anticholinesterase activity of petroleum ether and methanol extracts of the   plant and the isolated furocoumarins was investigated against   acetylcholinesterase and butyrylcholinesterase enzymes by the Ellman method   in vitro.

 

The petroleum ether extract of Heracleum platytaenium afforded 8 furocoumarins   (psoralen, bergapten, xanthotoxin, pimpinellin, isopimpinellin, sphondin,   byakangelicin, and heraclenol) and the methanol extract of H. platytaenium gave only 1   glycosylated dihydrofurocoumarin, apterin. In addition, stigmasterol was   also obtained from petroleum ether extract. Structure identification of the   isolated compounds has been achieved by using spectroscopic methods, namely   1D and 2D NMR experiments and mass spectral analyses. The antioxidant   activity of the extracts and pure compounds was investigated by 2 methods,   including DPPH free radical scavenging activity and lipid peroxidation   inhibitory activity by b-carotene-linoleic acid assays. The   anticholinesterase activity of petroleum ether and methanol extracts of the   plant and the isolated furocoumarins was investigated against   acetylcholinesterase and butyrylcholinesterase enzymes by the Ellman method   in vitro.

Article Details

Anticholinesterase furocoumarins from Heracleum platytaenium, a species endemic to the Ida Mountains

Authors: Demet DİNCEL | Seda Damla HATİPOĞLU | Ahmet Ceyhan GÖREN

Publisher: TUBITAK

Journal: Turkish Journal of Chemistry 2013 Vol.37 Issue 4, pp.675-683

Document Type: Article

Publication Date: 3/2013

Document Language: Turkish

Document ID (Org No.): 2000727398

Frequency: Bimonthly

eISSN: 1303-6130

pISSN: 1300-0527

Issues

Authors:

Demet DİNCEL | Seda Damla HATİPOĞLU | Ahmet Ceyhan GÖREN

Publisher:

TUBITAK

Journal:

Turkish Journal of Chemistry 2013 Vol.37 Issue 4, pp.675-683

Document Type:

Article

Publication Date:

3/2013

Document Language:

Turkish

Document ID (Org No.):

2000727398

Frequency:

Bimonthly

eISSN:

1303-6130

pISSN:

1300-0527