EVALUATION AND COMPARISON OF THE ANTIMICROBIAL AND CYTOTOXIC ACTIVITIES OF SOME AMINO ACID METHYL ESTERS

Tuğçe Deniz Karaca; Hüseyin Balcı; Arzu Aysan

Article Details

EVALUATION AND COMPARISON OF THE ANTIMICROBIAL AND CYTOTOXIC ACTIVITIES OF SOME AMINO ACID METHYL ESTERS

Authors:

Tuğçe Deniz Karaca | Hüseyin Balcı | Arzu Aysan

Publisher:

Hacettepe University

Main Topics:

Engineering

Journal:

Hacettepe Journal of Biology and Chemistry Vol.51 Issue 2, pp.133-140

Document Type:

Article

Publication Date:

1/2023

Document Language:

English

Document ID (Org No.):

2001281509

pISSN:

2687-475X

Keywords:

Abstract:

 In this study, the antibacterial and cytotoxic activities of some amino acid methyl esters L-methionine, L-phenylalanine, L-histidine, L-lysine, L-tryptophan, and L-tyrosine were investigated. The effect of amino acid methyl ester compounds on antibacterial performance was determinated against Gram-negative and Gram-positive bacteria. The effect of amino acid esters on cell viability was investigated against cancerous and non-cancerous cell lines using the MTS assay. The results showed the substances had low antimicrobial effect on both Gram-negative and Gram-positive bacteria. In addition, it was found that the studied substances did not have a toxic effect on cell growth in non-cancerous cells. For this reason, it is thought that the results obtained will contribute to research on new synthesizable compounds based on amino acid esters and studies on drug development.

 In this study, the antibacterial and cytotoxic activities of some amino acid methyl esters L-methionine, L-phenylalanine, L-histidine, L-lysine, L-tryptophan, and L-tyrosine were investigated. The effect of amino acid methyl ester compounds on antibacterial performance was determinated against Gram-negative and Gram-positive bacteria. The effect of amino acid esters on cell viability was investigated against cancerous and non-cancerous cell lines using the MTS assay. The results showed the substances had low antimicrobial effect on both Gram-negative and Gram-positive bacteria. In addition, it was found that the studied substances did not have a toxic effect on cell growth in non-cancerous cells. For this reason, it is thought that the results obtained will contribute to research on new synthesizable compounds based on amino acid esters and studies on drug development.

 In this study, the antibacterial and cytotoxic activities of some amino acid methyl esters L-methionine, L-phenylalanine, L-histidine, L-lysine, L-tryptophan, and L-tyrosine were investigated. The effect of amino acid methyl ester compounds on antibacterial performance was determinated against Gram-negative and Gram-positive bacteria. The effect of amino acid esters on cell viability was investigated against cancerous and non-cancerous cell lines using the MTS assay. The results showed the substances had low antimicrobial effect on both Gram-negative and Gram-positive bacteria. In addition, it was found that the studied substances did not have a toxic effect on cell growth in non-cancerous cells. For this reason, it is thought that the results obtained will contribute to research on new synthesizable compounds based on amino acid esters and studies on drug development.

 In this study, the antibacterial and cytotoxic activities of some amino acid methyl esters L-methionine, L-phenylalanine, L-histidine, L-lysine, L-tryptophan, and L-tyrosine were investigated. The effect of amino acid methyl ester compounds on antibacterial performance was determinated against Gram-negative and Gram-positive bacteria. The effect of amino acid esters on cell viability was investigated against cancerous and non-cancerous cell lines using the MTS assay. The results showed the substances had low antimicrobial effect on both Gram-negative and Gram-positive bacteria. In addition, it was found that the studied substances did not have a toxic effect on cell growth in non-cancerous cells. For this reason, it is thought that the results obtained will contribute to research on new synthesizable compounds based on amino acid esters and studies on drug development.

Article Details

EVALUATION AND COMPARISON OF THE ANTIMICROBIAL AND CYTOTOXIC ACTIVITIES OF SOME AMINO ACID METHYL ESTERS

Authors:

Tuğçe Deniz Karaca | Hüseyin Balcı | Arzu Aysan

Publisher:

Hacettepe University

Main Topics:

Engineering

Journal:

Hacettepe Journal of Biology and Chemistry Vol.51 Issue 2, pp.133-140

Document Type:

Article

Publication Date:

1/2023

Document Language:

English

Document ID (Org No.):

2001281509

pISSN:

2687-475X

Amino Acid Esters

Antibacterial Activity

Antiproliferative Activity

Cytotoxicity

Issues

Article Details

EVALUATION AND COMPARISON OF THE ANTIMICROBIAL AND CYTOTOXIC ACTIVITIES OF SOME AMINO ACID METHYL ESTERS

Authors: Tuğçe Deniz Karaca | Hüseyin Balcı | Arzu Aysan

Publisher: Hacettepe University

Main Topics: Engineering

Journal: Hacettepe Journal of Biology and Chemistry Vol.51 Issue 2, pp.133-140

Document Type: Article

Publication Date: 1/2023

Document Language: English

Document ID (Org No.): 2001281509

pISSN: 2687-475X

Amino Acid Esters

Antibacterial Activity

Antiproliferative Activity

Cytotoxicity

Issues

Authors:

Tuğçe Deniz Karaca | Hüseyin Balcı | Arzu Aysan

Publisher:

Hacettepe University

Main Topics:

Engineering

Journal:

Hacettepe Journal of Biology and Chemistry Vol.51 Issue 2, pp.133-140

Document Type:

Article

Publication Date:

1/2023

Document Language:

English

Document ID (Org No.):

2001281509

pISSN:

2687-475X