Effects of Praziquantel and Albendazole on Coenurus cerebralisin  Experimentally Infected Lambs

Gülay BIYIKOĞLU

Article Details

Effects of Praziquantel and Albendazole on Coenurus cerebralisin Experimentally Infected Lambs

Authors:

Gülay BIYIKOĞLU

Publisher:

TUBITAK

Journal:

Turkish Journal of Veterinary and Animal Sciences 1998 Vol.22 Issue 1, pp.43-48

Document Type:

Article

Publication Date:

12/1997

Document Language:

Turkish

Document ID (Org No.):

2000772686

Frequency:

Bimonthly

eISSN:

1303-6181

pISSN:

1300-0128

Keywords:

Abstract:

 

In this study, effects of praziquantel and albendazole on Coenurus cerabralis were investigated. For this purpose, 5 dogs  aged 2.5-3 months and 21 akkaraman lambs aged 3-4 months were used. Three dogs were infected with Coenurus cerebralis protoscoleces,  then the eggs collected from their feces were given to the lambs. Approximately 5500 eggs were given to each lamb.  The lambs were divided into three groups consisting of 7 lambs each. The drug administration started at the first day of the occurrence  of the semptoms of coenurosis. Praziquantel a dose of 25 mg/kg for 3 days and albendazole a dose of 10 mg/kg for 14 days  were given to the first and to the second group respectively. The third group was kept as control. Four lambs from the first group  and 3 lambs from the second group were able to survive until the programmed necropsy date but the others died. Clinical recovery  was observed in two sheep from both group until the day that necropsy was performed.  It was found that 21 (60%) of 35 cysts were degenerated and 14 (40%) of 35 cysts were death in praziquantel treatment group.  Ten (23.80%) of 42 cysts were degenerated, 13 (30.95%) of 42 cysts were death and 19 (45.23%) of 42 cysts were alive in  albendazole treatment group. It was determined that 34 (97.14%) of the 35 cysts were alive in the control group while the  remaining 1 (2.85%) was had calcification. The protoscoleces that were obtained from the animals in both drug administration  groups were orally given to 2 diferent dogs, but no mature cestod was observed in these dogs.

 

In this study, effects of praziquantel and albendazole on Coenurus cerabralis were investigated. For this purpose, 5 dogs  aged 2.5-3 months and 21 akkaraman lambs aged 3-4 months were used. Three dogs were infected with Coenurus cerebralis protoscoleces,  then the eggs collected from their feces were given to the lambs. Approximately 5500 eggs were given to each lamb.  The lambs were divided into three groups consisting of 7 lambs each. The drug administration started at the first day of the occurrence  of the semptoms of coenurosis. Praziquantel a dose of 25 mg/kg for 3 days and albendazole a dose of 10 mg/kg for 14 days  were given to the first and to the second group respectively. The third group was kept as control. Four lambs from the first group  and 3 lambs from the second group were able to survive until the programmed necropsy date but the others died. Clinical recovery  was observed in two sheep from both group until the day that necropsy was performed.  It was found that 21 (60%) of 35 cysts were degenerated and 14 (40%) of 35 cysts were death in praziquantel treatment group.  Ten (23.80%) of 42 cysts were degenerated, 13 (30.95%) of 42 cysts were death and 19 (45.23%) of 42 cysts were alive in  albendazole treatment group. It was determined that 34 (97.14%) of the 35 cysts were alive in the control group while the  remaining 1 (2.85%) was had calcification. The protoscoleces that were obtained from the animals in both drug administration  groups were orally given to 2 diferent dogs, but no mature cestod was observed in these dogs.

Article Details

Effects of Praziquantel and Albendazole on Coenurus cerebralisin Experimentally Infected Lambs

Authors: Gülay BIYIKOĞLU

Publisher: TUBITAK

Journal: Turkish Journal of Veterinary and Animal Sciences 1998 Vol.22 Issue 1, pp.43-48

Document Type: Article

Publication Date: 12/1997

Document Language: Turkish

Document ID (Org No.): 2000772686

Frequency: Bimonthly

eISSN: 1303-6181

pISSN: 1300-0128

Coenurus cerebralis

praziquantel

albendazole

sheep

lambs

Issues

Authors:

Gülay BIYIKOĞLU

Publisher:

TUBITAK

Journal:

Turkish Journal of Veterinary and Animal Sciences 1998 Vol.22 Issue 1, pp.43-48

Document Type:

Article

Publication Date:

12/1997

Document Language:

Turkish

Document ID (Org No.):

2000772686

Frequency:

Bimonthly

eISSN:

1303-6181

pISSN:

1300-0128