Spectroscopic investigation and oxidation of the anticholinergic drug atropine sulfate monohydrate by hexacyanoferrate(III) in aqueous alkaline media: a mechanistic approach

Manjunath METI; Sharanappa NANDIBEWOOR; Shivamurti CHIMATADAR

Article Details

Spectroscopic investigation and oxidation of the anticholinergic drug atropine sulfate monohydrate by hexacyanoferrate(III) in aqueous alkaline media: a mechanistic approach

Authors:

Manjunath METI | Sharanappa NANDIBEWOOR | Shivamurti CHIMATADAR

Publisher:

TUBITAK

Journal:

Turkish Journal of Chemistry 2014 Vol.38 Issue 3, pp.477-487

Document Type:

Article

Publication Date:

5/2014

Document Language:

Turkish

Document ID (Org No.):

2000727180

Frequency:

Bimonthly

eISSN:

1303-6130

pISSN:

1300-0527

Abstract:

 

The oxidation of the anticholinergic drug atropine sulfate monohydrate by hexacyanoferrate(III) in aqueous alkaline media was investigated spectrophotometrically by monitoring the decrease in absorbance of hexacyanoferrate(III) (HCF(III)). Oxidation products were identified. The oxidation mechanism was proposed from kinetic studies. The reaction constants involved in the different steps of the mechanism were calculated. The effects of added products, ionic strength, and dielectric constant of the reaction were investigated. The polymerization test revealed that oxidation occurred with intervention of free radicals. The activation parameters were evaluated.

 

The oxidation of the anticholinergic drug atropine sulfate monohydrate by hexacyanoferrate(III) in aqueous alkaline media was investigated spectrophotometrically by monitoring the decrease in absorbance of hexacyanoferrate(III) (HCF(III)). Oxidation products were identified. The oxidation mechanism was proposed from kinetic studies. The reaction constants involved in the different steps of the mechanism were calculated. The effects of added products, ionic strength, and dielectric constant of the reaction were investigated. The polymerization test revealed that oxidation occurred with intervention of free radicals. The activation parameters were evaluated.

Article Details

Spectroscopic investigation and oxidation of the anticholinergic drug atropine sulfate monohydrate by hexacyanoferrate(III) in aqueous alkaline media: a mechanistic approach

Authors: Manjunath METI | Sharanappa NANDIBEWOOR | Shivamurti CHIMATADAR

Publisher: TUBITAK

Journal: Turkish Journal of Chemistry 2014 Vol.38 Issue 3, pp.477-487

Document Type: Article

Publication Date: 5/2014

Document Language: Turkish

Document ID (Org No.): 2000727180

Frequency: Bimonthly

eISSN: 1303-6130

pISSN: 1300-0527

Issues

Authors:

Manjunath METI | Sharanappa NANDIBEWOOR | Shivamurti CHIMATADAR

Publisher:

TUBITAK

Journal:

Turkish Journal of Chemistry 2014 Vol.38 Issue 3, pp.477-487

Document Type:

Article

Publication Date:

5/2014

Document Language:

Turkish

Document ID (Org No.):

2000727180

Frequency:

Bimonthly

eISSN:

1303-6130

pISSN:

1300-0527