Syntheses of N-acylhydrazones of 2-hydroxy-3,5-dinitrobenzohydrazide, and their Conversion into 3-Acetyl-2,3-dihydro-1,3,4-oxadiazole

Rami Y. Morjan; Feda J. Ghonium; Jannat N. Azarah; Omar S. Abu-Teim; Adel M. Awadallah; Mariam R. Al-Reefi; Abdelrauof A. Elmanama; John M. Gardiner

Article Details

Syntheses of N-acylhydrazones of 2-hydroxy-3,5-dinitrobenzohydrazide, and their Conversion into 3-Acetyl-2,3-dihydro-1,3,4-oxadiazole

Authors:

Rami Y. Morjan | Feda J. Ghonium | Jannat N. Azarah | Omar S. Abu-Teim | Adel M. Awadallah | Mariam R. Al-Reefi | Abdelrauof A. Elmanama | John M. Gardiner

Publisher:

Islamic University of Gaza

Journal:

IUG Journal of Natural Studies Vol.30 Issue 2, pp.0-0

Document Type:

Article

Publication Date:

1/2022

Document Language:

English

Document ID (Org No.):

2001390418

pISSN:

2790-1653

Keywords:

Abstract:

 N -Acylhydrazones  11-17  were prepared  via  reaction of 2-hydroxy-3,5-dinitrobenzohydrazide  3  with aromatic aldehydes  4-6  or with aromatic ketone  7  or aliphatic acyclic ketone  8  and cyclic aliphatic ketones  9-10  under reflux in ethanol. Conversion of hydrazide hydrazone  17  into  N -acetyl-1,3,4-oxadiazole derivative  19  was achieved    via  reaction   with acetic anhydride  18 .   The products were characterized by MS,  1 H-NMR and  13 C-NMR. The structure of  19  was confirmed by X-ray analysis. Compound  19  was evaluated for  in   vitro  antibacterial activity against two microorganisms   ( S. aureus  and  E. coli  ).   The obtained results showed that this compound has good inhibition against the tested bacterial pathogens by micro-dilution method   with MIC 15.1 μg.

Article Details

Syntheses of N-acylhydrazones of 2-hydroxy-3,5-dinitrobenzohydrazide, and their Conversion into 3-Acetyl-2,3-dihydro-1,3,4-oxadiazole

Authors:

Rami Y. Morjan | Feda J. Ghonium | Jannat N. Azarah | Omar S. Abu-Teim | Adel M. Awadallah | Mariam R. Al-Reefi | Abdelrauof A. Elmanama | John M. Gardiner

Publisher:

Islamic University of Gaza

Journal:

IUG Journal of Natural Studies Vol.30 Issue 2, pp.0-0

Document Type:

Article

Publication Date:

1/2022

Document Language:

English

Document ID (Org No.):

2001390418

pISSN:

2790-1653

Hydrazide-Hydrazone

3

5-dinitrosalicylaic acid

1

3

4-oxadiazole

antibacterial activity

Issues

Article Details

Authors: Rami Y. Morjan | Feda J. Ghonium | Jannat N. Azarah | Omar S. Abu-Teim | Adel M. Awadallah | Mariam R. Al-Reefi | Abdelrauof A. Elmanama | John M. Gardiner

Publisher: Islamic University of Gaza

Journal: IUG Journal of Natural Studies Vol.30 Issue 2, pp.0-0

Document Type: Article

Publication Date: 1/2022

Document Language: English

Document ID (Org No.): 2001390418

pISSN: 2790-1653

Issues

Authors:

Rami Y. Morjan | Feda J. Ghonium | Jannat N. Azarah | Omar S. Abu-Teim | Adel M. Awadallah | Mariam R. Al-Reefi | Abdelrauof A. Elmanama | John M. Gardiner

Publisher:

Islamic University of Gaza

Journal:

IUG Journal of Natural Studies Vol.30 Issue 2, pp.0-0

Document Type:

Article

Publication Date:

1/2022

Document Language:

English

Document ID (Org No.):

2001390418

pISSN:

2790-1653