Carica papaya Fruit Attenuates Apoptotic Degeneration After Permanent Cerebral Ischemia Rat

Pratchaya Kaewkaen

doi:10.3844/ajbbsp.2018.255.261

Article Details

Carica papaya Fruit Attenuates Apoptotic Degeneration After Permanent Cerebral Ischemia Rat

Authors:

Pratchaya Kaewkaen

Publisher:

Science Publications

Journal:

American Journal of Biochemistry and Biotechnology Vol.14 Issue 4, pp.255-261

Document Type:

Article

Publication Date:

11/2018

Document Language:

English

Document ID (Org No.):

2001397316

pISSN:

1558-6332

DOI:

10.3844/ajbbsp.2018.255.261

Keywords:

Abstract:

 Apoptotic neurodegeneration is a phenomenon following cerebral ischemia. Both the increased caspase-3 and decreased Bcl-2 expression are reported to play crucial role on apoptosis in neuron. In addition, phytonutrient can successfully increase the endogenous antioxidant and lower the apoptotic responses. Therefore, anti-apoptotic effect of Carica papaya fruits was examined. To the best of our knowledge, no scientific effect was available. Therefore this study aimed to determine the effect of Carica papaya on neuron density and the densities of both caspase-3 and Bcl-2 immunopositive neuron in hippocampus. Adult male Wistar rats, weighing 280-320 g, were orally given Carica papaya fruits extract at doses of 50, 150 and 450 mg/kg at a period of 14 days before and 14 days after the occlusion of right Middle Cerebral Artery (Rt.MCAO). The results showed that Carica papaya fruits at high doses used in this study significantly attenuated the decreased neuron density in hippocampus. In addition, the high doses of Carica papaya could decrease caspase-3 immunopositive neuron density but increased density of Bcl-2 immunopositive neurons in hippocampus. The decreased caspase-3 immunopositive neuron density and the increased Bcl-2- immunopositive neurons might be partly responsible for neuroprotective effect of Carica papaya. Therefore, Carica papaya is the potential fruit to protect against apoptotic neurodegeneration following cerebral ischemia. However, further researches are essential to elucidate the possible mechanism.

Article Details

Carica papaya Fruit Attenuates Apoptotic Degeneration After Permanent Cerebral Ischemia Rat

Authors:

Pratchaya Kaewkaen

Publisher:

Science Publications

Journal:

American Journal of Biochemistry and Biotechnology Vol.14 Issue 4, pp.255-261

Document Type:

Article

Publication Date:

11/2018

Document Language:

English

Document ID (Org No.):

2001397316

pISSN:

1558-6332

DOI:

10.3844/ajbbsp.2018.255.261

Carica papaya

Apoptosis

Neurodegeneration

Cerebral Ischemia

Issues

Article Details

Carica papaya Fruit Attenuates Apoptotic Degeneration After Permanent Cerebral Ischemia Rat

Authors: Pratchaya Kaewkaen

Publisher: Science Publications

Journal: American Journal of Biochemistry and Biotechnology Vol.14 Issue 4, pp.255-261

Document Type: Article

Publication Date: 11/2018

Document Language: English

Document ID (Org No.): 2001397316

pISSN: 1558-6332

DOI: 10.3844/ajbbsp.2018.255.261

Carica papaya

Apoptosis

Neurodegeneration

Cerebral Ischemia

Issues

Authors:

Pratchaya Kaewkaen

Publisher:

Science Publications

Journal:

American Journal of Biochemistry and Biotechnology Vol.14 Issue 4, pp.255-261

Document Type:

Article

Publication Date:

11/2018

Document Language:

English

Document ID (Org No.):

2001397316

pISSN:

1558-6332

DOI:

10.3844/ajbbsp.2018.255.261