Histopathologic Profile of Ocular Lesions in A Tertiary Care Hospital: A Retrospective Cross-Sectional Study

Fatma Sümer; Çiğdem Öztürk

Article Details

Histopathologic Profile of Ocular Lesions in A Tertiary Care Hospital: A Retrospective Cross-Sectional Study

Authors:

Fatma Sümer | Çiğdem Öztürk

Publisher:

Duzce University

Main Topics:

Klinik Tıp Bilimleri (Diğer)

Journal:

Sağlık Bilimlerinde Değer Vol.15 Issue 3, pp.377-384

Document Type:

Article

Publication Date:

9/2025

Document Language:

Turkish

Document ID (Org No.):

2001358908

pISSN:

2792-0542

Keywords:

Abstract:

 Aim: This study aimed to evaluate the epidemiological characteristics of histopathological specimens obtained from surgically excised ocular surface lesions and to determine the concordance rate between preliminary clinical diagnoses and final histopathological findings. Additionally, the role of histopathological analysis in guiding diagnostic processes and contributing to clinical decision-making was emphasized. Material and Methods: This retrospective cross-sectional study was conducted between 2011 and 2022 at the Departments of Ophthalmology and Medical Pathology, Recep Tayyip Erdoğan University Faculty of Medicine. A total of 1116 tissue specimens obtained via surgical excision for ocular pathology were included. Demographic data such as age and sex, preliminary clinical diagnoses, and histopathological results were retrospectively analyzed. Diagnostic accuracy and concordance between clinical impressions and pathological findings were systematically assessed. Results: The mean age of the patients was 53.1 years range: 495, with females comprising 60.4 of the cohort. The overall concordance rate between clinical and histopathological diagnoses was 75.1. Diagnostic accuracy for malignancies was remarkably high at 98.9. Xanthelasma was the most frequently observed lesion 12.8, while sebaceous carcinoma, sebaceous hyperplasia, and steatocytoma were among the rarest, each accounting for only 0.09 of cases. The overall malignancy rate was calculated as 4.7. Conclusion: Histopathological evaluation is indispensable not only for confirming definitive diagnoses but also for establishing appropriate treatment strategies, guiding clinical management, and improving long-term patient outcomes. Therefore, integrating pathological verification with clinical assessments is essential for safe, accurate, and effective management of ocular surface lesions.

 Aim: This study aimed to evaluate the epidemiological characteristics of histopathological specimens obtained from surgically excised ocular surface lesions and to determine the concordance rate between preliminary clinical diagnoses and final histopathological findings. Additionally, the role of histopathological analysis in guiding diagnostic processes and contributing to clinical decision-making was emphasized. Material and Methods: This retrospective cross-sectional study was conducted between 2011 and 2022 at the Departments of Ophthalmology and Medical Pathology, Recep Tayyip Erdoğan University Faculty of Medicine. A total of 1116 tissue specimens obtained via surgical excision for ocular pathology were included. Demographic data such as age and sex, preliminary clinical diagnoses, and histopathological results were retrospectively analyzed. Diagnostic accuracy and concordance between clinical impressions and pathological findings were systematically assessed. Results: The mean age of the patients was 53.1 years range: 495, with females comprising 60.4 of the cohort. The overall concordance rate between clinical and histopathological diagnoses was 75.1. Diagnostic accuracy for malignancies was remarkably high at 98.9. Xanthelasma was the most frequently observed lesion 12.8, while sebaceous carcinoma, sebaceous hyperplasia, and steatocytoma were among the rarest, each accounting for only 0.09 of cases. The overall malignancy rate was calculated as 4.7. Conclusion: Histopathological evaluation is indispensable not only for confirming definitive diagnoses but also for establishing appropriate treatment strategies, guiding clinical management, and improving long-term patient outcomes. Therefore, integrating pathological verification with clinical assessments is essential for safe, accurate, and effective management of ocular surface lesions.

 Aim: This study aimed to evaluate the epidemiological characteristics of histopathological specimens obtained from surgically excised ocular surface lesions and to determine the concordance rate between preliminary clinical diagnoses and final histopathological findings. Additionally, the role of histopathological analysis in guiding diagnostic processes and contributing to clinical decision-making was emphasized. Material and Methods: This retrospective cross-sectional study was conducted between 2011 and 2022 at the Departments of Ophthalmology and Medical Pathology, Recep Tayyip Erdoğan University Faculty of Medicine. A total of 1116 tissue specimens obtained via surgical excision for ocular pathology were included. Demographic data such as age and sex, preliminary clinical diagnoses, and histopathological results were retrospectively analyzed. Diagnostic accuracy and concordance between clinical impressions and pathological findings were systematically assessed. Results: The mean age of the patients was 53.1 years range: 495, with females comprising 60.4 of the cohort. The overall concordance rate between clinical and histopathological diagnoses was 75.1. Diagnostic accuracy for malignancies was remarkably high at 98.9. Xanthelasma was the most frequently observed lesion 12.8, while sebaceous carcinoma, sebaceous hyperplasia, and steatocytoma were among the rarest, each accounting for only 0.09 of cases. The overall malignancy rate was calculated as 4.7. Conclusion: Histopathological evaluation is indispensable not only for confirming definitive diagnoses but also for establishing appropriate treatment strategies, guiding clinical management, and improving long-term patient outcomes. Therefore, integrating pathological verification with clinical assessments is essential for safe, accurate, and effective management of ocular surface lesions.

 Amaç: Bu çalışmada, oküler yüzey lezyonlarına ait cerrahi olarak çıkarılmış histopatolojik örneklerin epidemiyolojik özelliklerinin değerlendirilmesi ve klinik ön tanı ile histopatolojik tanılar arasındaki uyum oranının belirlenmesi amaçlanmıştır. Aynı zamanda histopatolojik incelemenin tanısal süreçlerdeki rolü ve hasta yönetimine katkısı ortaya konulmaya çalışılmıştır. Gereç ve Yöntemler: Bu retrospektif kesitsel araştırma, 2011 ile 2022 yılları arasında Recep Tayyip Erdoğan Üniversitesi Tıp Fakültesi Göz Hastalıkları ile Tıbbi Patoloji Anabilim Dallarının iş birliğiyle yürütülmüştür. Oküler patoloji nedeniyle cerrahi eksizyon yapılan ve histopatolojik değerlendirme için gönderilen toplam 1116 örnek incelenmiştir. Hastaların yaş, cinsiyet gibi demografik bilgileri, klinik ön tanıları ve histopatolojik tanıları retrospektif olarak analiz edilmiştir. Klinik tanılar ile histopatolojik bulgular karşılaştırılarak tanısal doğruluk ve uyum değerlendirilmiştir. Bulgular: Olguların yaş ortalaması 53,1 olup yaş aralığı 495, 60,4ü kadın hastalardan oluşmaktaydı. Klinik ön tanı ile histopatolojik tanı arasında 75,1 oranında uyum saptanmıştır. Malignite tanılarındaki doğruluk oranı oldukça yüksektir 98,9. En sık rastlanan lezyon ksantelazma olup 12,8, sebase karsinom, sebase hiperplazi ve steatositoma en nadir görülen lezyonlar olarak her biri 0,09 oranında tespit edilmiştir. Genel malignite oranı 4,7dir. Sonuç: Histopatolojik inceleme, yalnızca kesin tanıya ulaşmak için değil; aynı zamanda etkili tedavi planlaması, klinik yönetimin yönlendirilmesi ve hasta prognozunun iyileştirilmesi açısından da vazgeçilmez bir unsurdur. Bu nedenle, klinik gözlemlerle birlikte patolojik doğrulama yapılması, oküler yüzey lezyonlarında güvenilir hasta yönetimi için kritik öneme sahiptir.

Article Details

Histopathologic Profile of Ocular Lesions in A Tertiary Care Hospital: A Retrospective Cross-Sectional Study

Authors:

Fatma Sümer | Çiğdem Öztürk

Publisher:

Duzce University

Main Topics:

Klinik Tıp Bilimleri (Diğer)

Journal:

Sağlık Bilimlerinde Değer Vol.15 Issue 3, pp.377-384

Document Type:

Article

Publication Date:

9/2025

Document Language:

Turkish

Document ID (Org No.):

2001358908

pISSN:

2792-0542

ocular lesion

pathology

malignancy

histopathologyOküler lezyon

patoloji

malignite

histopatoloji

Issues

Article Details

Authors: Fatma Sümer | Çiğdem Öztürk

Publisher: Duzce University

Main Topics: Klinik Tıp Bilimleri (Diğer)

Journal: Sağlık Bilimlerinde Değer Vol.15 Issue 3, pp.377-384

Document Type: Article

Publication Date: 9/2025

Document Language: Turkish

Document ID (Org No.): 2001358908

pISSN: 2792-0542

Issues

Authors:

Fatma Sümer | Çiğdem Öztürk

Publisher:

Duzce University

Main Topics:

Klinik Tıp Bilimleri (Diğer)

Journal:

Sağlık Bilimlerinde Değer Vol.15 Issue 3, pp.377-384

Document Type:

Article

Publication Date:

9/2025

Document Language:

Turkish

Document ID (Org No.):

2001358908

pISSN:

2792-0542