Canine Cognitive Dysfunction Patients Have Reduced Total Hippocampal Volume Compared with Aging Control Dogs : A Comparative Magnetic Resonance Imaging Study

Dewey , Curtis Wells; Rishniw , Mark; Johnson , Philippa J.; Platt , Simon; Robinson , Kelsey; Sackman , Joseph; O’Donnell , Marissa

doi:10.4314/ovj.v10i4.11

Article Details

Canine Cognitive Dysfunction Patients Have Reduced Total Hippocampal Volume Compared with Aging Control Dogs : A Comparative Magnetic Resonance Imaging Study

Authors:

Dewey , Curtis Wells | Rishniw , Mark | Johnson , Philippa J. | Platt , Simon | Robinson , Kelsey | Sackman , Joseph | O’Donnell , Marissa

Publisher:

Faculty of Veterinary Medicine, University of Tripoli

Main Topics:

Medicine | Zoological sciences/Animals

Journal:

Open Veterinary Journal 2020 Vol.10 Issue 4, pp.438-442

Document Type:

Article

Publication Date:

12/2020

Document Language:

English

Document ID (Org No.):

244346

Frequency:

Tri-Annual

eISSN:

22186050

pISSN:

22264485

DOI:

10.4314/ovj.v10i4.11

Descriptors:

Keywords:

Abstract:

 Background: Hippocampal atrophy is a key pathologic and magnetic resonance imaging (MRI) feature of humanAlzheimer’s disease (AD). Hippocampal atrophy has not been documented via MRI in canine cognitive dysfunction(CCD), which is considered as the dog model of human AD.Aim: The purpose of this retrospective comparative volumetric MRI study was to compare total hippocampal volumesbetween successfully aging (control) dogs and dogs diagnosed with CCD.Methods: Mimics® software was used to derive total hippocampal volumes and total brain volumes from the MRIstudies of 42 aging dogs (≥ 9 years): 16 dogs diagnosed with CCD and 26 successfully aging controls. Hippocampalvolumes were normalized to total brain volume and these values were compared between groups using Mann–WhitneyU tests.Results: Total hippocampal volume normalized to total brain volume was significantly less for CCD patients comparedwith control dogs (p = 0.04).Conclusion: The results of this study suggest that – similar to human AD – hippocampal atrophy is a pathologicalfeature of CCD. This finding has potential importance for both investigating disease mechanisms related to dementiaas well as future hippocampal-targeted therapies.

Article Details

Canine Cognitive Dysfunction Patients Have Reduced Total Hippocampal Volume Compared with Aging Control Dogs : A Comparative Magnetic Resonance Imaging Study

Authors:

Dewey , Curtis Wells | Rishniw , Mark | Johnson , Philippa J. | Platt , Simon | Robinson , Kelsey | Sackman , Joseph | O’Donnell , Marissa

Publisher:

Faculty of Veterinary Medicine, University of Tripoli

Main Topics:

Medicine | Zoological sciences/Animals

Journal:

Open Veterinary Journal 2020 Vol.10 Issue 4, pp.438-442

Document Type:

Article

Publication Date:

12/2020

Document Language:

English

Document ID (Org No.):

244346

Frequency:

Tri-Annual

eISSN:

22186050

pISSN:

22264485

DOI:

10.4314/ovj.v10i4.11

Descriptors:

VETERINARY MEDICINE

ALZHEIMER'S DISEASE

HIPPOCAMPUS

MAGNETIC RESONANCE IMAGING

DOGS

Canine

Cognitive

Dog

Hippocampal

Volume

Issues

Article Details

Authors: Dewey , Curtis Wells | Rishniw , Mark | Johnson , Philippa J. | Platt , Simon | Robinson , Kelsey | Sackman , Joseph | O’Donnell , Marissa

Publisher: Faculty of Veterinary Medicine, University of Tripoli

Main Topics: Medicine | Zoological sciences/Animals

Journal: Open Veterinary Journal 2020 Vol.10 Issue 4, pp.438-442

Document Type: Article

Publication Date: 12/2020

Document Language: English

Document ID (Org No.): 244346

Frequency: Tri-Annual

eISSN: 22186050

pISSN: 22264485

DOI: 10.4314/ovj.v10i4.11

Descriptors:

Issues

Authors:

Dewey , Curtis Wells | Rishniw , Mark | Johnson , Philippa J. | Platt , Simon | Robinson , Kelsey | Sackman , Joseph | O’Donnell , Marissa

Publisher:

Faculty of Veterinary Medicine, University of Tripoli

Main Topics:

Medicine | Zoological sciences/Animals

Journal:

Open Veterinary Journal 2020 Vol.10 Issue 4, pp.438-442

Document Type:

Article

Publication Date:

12/2020

Document Language:

English

Document ID (Org No.):

244346

Frequency:

Tri-Annual

eISSN:

22186050

pISSN:

22264485

DOI:

10.4314/ovj.v10i4.11