Amygdalin and magnetic water ameliorate histological changes in liver induced by 1, 2 dimethyl hydrazine

Ahmed S. Farhan

doi:10.30539/iraqijvm.v40i1.150

Article Details

Amygdalin and magnetic water ameliorate histological changes in liver induced by 1, 2 dimethyl hydrazine

Authors:

Ahmed S. Farhan

Publisher:

University of Baghdad

Journal:

The Iraqi Journal of Veterinary Medicine Vol.40 Issue 1, pp.136-139

Document Type:

Article

Publication Date:

5/2016

Document Language:

English

Document ID (Org No.):

2001378443

pISSN:

2410-7409

DOI:

10.30539/iraqijvm.v40i1.150

Keywords:

Abstract:

  This study aimed at evaluating the ameliorative effect of amygdalin and magnetic water on 1,2-dimethyl hydrazine induced toxic damage in tissues and oxidative stress in rat liver. Seven groups of ten rats each were selected for the study. Group I animals were treated as control. Group II rats received 1,2-dimethyl hydrazine (20 mg/kg body weight) injections subcutaneously once a week for 16 consecutive weeks and then kept without any treatment untill the end of the experimental period. Group III rats received amygdalin (20 mg/100 mg) daily via Oro-gastric tube. Groups IV rats were given magnetic water freely. Group V rats were given 1,2-dimethyl hydrazine + amygdalin. Group VI rat were given 1,2-dimethyl hydrazine + magnetic water Group VII rats were given 1,2-dimethyl hydrazine + amygdalin + magnetic water. Liver histological changes were studied. Degenerative changes were observed in different areas of liver tissue in 1,2-dimethyl hydrazine group, and these changes include: Fibrosis with the appearance of cell necrosis, hemorrhage, fatty infiltration and pleomorphic nuclei. While other groups showed normal appearance of the hepatic cells but some changes were observed in 1,2-dimethyl hydrazine + amygdalin + magnetic water group include: Fibrosis with the appearance of cell necrosis, hemorrhage, fatty infiltration and pleomorphic nuclei but changes in this group were less than in 1,2-dimethyl hydrazine group. In conclusion, the present results suggest that the amygdalin and magnetic water have the potential to ameliorate carcinogen 1,2-dimethyl hydrazine induced hepatotoxicity by antioxidant and antiinflammation activity.

Article Details

Amygdalin and magnetic water ameliorate histological changes in liver induced by 1, 2 dimethyl hydrazine

Authors:

Ahmed S. Farhan

Publisher:

University of Baghdad

Journal:

The Iraqi Journal of Veterinary Medicine Vol.40 Issue 1, pp.136-139

Document Type:

Article

Publication Date:

5/2016

Document Language:

English

Document ID (Org No.):

2001378443

pISSN:

2410-7409

DOI:

10.30539/iraqijvm.v40i1.150

Amygdalin

Magnetic water

1

2-dimethyl hydrazine

Rat liver

Issues

Article Details

Amygdalin and magnetic water ameliorate histological changes in liver induced by 1, 2 dimethyl hydrazine

Authors: Ahmed S. Farhan

Publisher: University of Baghdad

Journal: The Iraqi Journal of Veterinary Medicine Vol.40 Issue 1, pp.136-139

Document Type: Article

Publication Date: 5/2016

Document Language: English

Document ID (Org No.): 2001378443

pISSN: 2410-7409

DOI: 10.30539/iraqijvm.v40i1.150

Amygdalin

Magnetic water

1

2-dimethyl hydrazine

Rat liver

Issues

Authors:

Ahmed S. Farhan

Publisher:

University of Baghdad

Journal:

The Iraqi Journal of Veterinary Medicine Vol.40 Issue 1, pp.136-139

Document Type:

Article

Publication Date:

5/2016

Document Language:

English

Document ID (Org No.):

2001378443

pISSN:

2410-7409

DOI:

10.30539/iraqijvm.v40i1.150