The Relation between Mean Platelet Volume and Mortality in Critically Ill Children

Osama E. Bekhit; Hanaa H. Mahmoud; Hoiyda A. Abdelrasol; Ahmed M. El Sayed Rezk

doi:10.12816/0052994

Article Details

The Relation between Mean Platelet Volume and Mortality in Critically Ill Children

Authors:

Osama E. Bekhit | Hanaa H. Mahmoud | Hoiyda A. Abdelrasol | Ahmed M. El Sayed Rezk

Publisher:

Ain Shams University : Egyptian Paediatric Society

Main Topics:

Medicine

Journal:

Egyptian Journal of Pediatrics 2019 Vol.36 Issue 1-2, pp.301-311

Document Type:

Article

Publication Date:

6/2019

Document Language:

English

Document ID (Org No.):

133446

Frequency:

Quarterly

pISSN:

16871677

DOI:

10.12816/0052994

Descriptors:

Keywords:

Abstract:

 Background: Critically-ill patients usually show alterations in platelet indices including platelet volume. It has been stated that increased mean platelet volume (MPV) was associated with mortality in adult populations. Few studies, however, have evaluated MPV for the in-hospital mortality in critically ill children. Objective: The aim of this study was to assess the prognostic value of MPV in critically ill children in pediatric intensive care unit (PICU) and to compare the performance of MPV in relation to PRISM-III score.Methods: This prospective cohort study was conducted at Fayoum University Hospital. Data were collected consecutively from 100 eligible critically ill patients admitted to PICU. All patients were subjected to full history taking and thorough medical assessment. Complete blood counts were performed within 1 hour and after 48 hours of PICU admission. MPV1, MPV2, and ΔMPV (MPV2 - MPV1) values were recorded.Results: There was a significant association between the change in MPV (ΔMPV) and mortality. Non-survivors showed significantly greater increase in MPV than survivors (p = 0.006). Analysis of receiver operating characteristic (ROC) curve for prediction of mortality using MPV change revealed that ΔMPV at a cutoff of > 2.2 fl had a significant discriminatory power with sensitivity of 73.9% and specificity of 64.5%. Additionally, ΔMPV > 0 had about 4-fold risk of mortality than those with ΔMPV ≤ 0 (OR: 3.694, P-value: 0.018). Concerning PRISM-III score, each unit of increase was associated with an increased likelihood of mortality by more than one-fold (OR=1.151).Conclusion: The change in MPV within 48 hours of admission to PICU is a significant independent predictor of mortality, with a predictive ability comparable to that of PRISM-III score.

Article Details

The Relation between Mean Platelet Volume and Mortality in Critically Ill Children

Authors:

Osama E. Bekhit | Hanaa H. Mahmoud | Hoiyda A. Abdelrasol | Ahmed M. El Sayed Rezk

Publisher:

Ain Shams University : Egyptian Paediatric Society

Main Topics:

Medicine

Journal:

Egyptian Journal of Pediatrics 2019 Vol.36 Issue 1-2, pp.301-311

Document Type:

Article

Publication Date:

6/2019

Document Language:

English

Document ID (Org No.):

133446

Frequency:

Quarterly

pISSN:

16871677

DOI:

10.12816/0052994

Descriptors:

PAEDIATRICS

PLATELETS

DISEASES

CHILDREN DISEASES

CHILDREN

DIAGNOSIS

EGYPT

Mean Platelet Volume

MPV

Pediatric ICU

Critically Ill Children

Prognosis

Risk Stratification

Issues

Article Details

Authors: Osama E. Bekhit | Hanaa H. Mahmoud | Hoiyda A. Abdelrasol | Ahmed M. El Sayed Rezk

Publisher: Ain Shams University : Egyptian Paediatric Society

Main Topics: Medicine

Journal: Egyptian Journal of Pediatrics 2019 Vol.36 Issue 1-2, pp.301-311

Document Type: Article

Publication Date: 6/2019

Document Language: English

Document ID (Org No.): 133446

Frequency: Quarterly

pISSN: 16871677

DOI: 10.12816/0052994

Descriptors:

Issues

Authors:

Osama E. Bekhit | Hanaa H. Mahmoud | Hoiyda A. Abdelrasol | Ahmed M. El Sayed Rezk

Publisher:

Ain Shams University : Egyptian Paediatric Society

Main Topics:

Medicine

Journal:

Egyptian Journal of Pediatrics 2019 Vol.36 Issue 1-2, pp.301-311

Document Type:

Article

Publication Date:

6/2019

Document Language:

English

Document ID (Org No.):

133446

Frequency:

Quarterly

pISSN:

16871677

DOI:

10.12816/0052994