Correlation between Serum Interleukin-31 Level and the Severity of Atopic Dermatitis in Children

Atallah , Rabie Bedir; Amer , Ahmed Wahhed-Allah; Abd El-Samee , Hesham Samir; Ibraheem , Reham Mahmoud

Article Details

Correlation between Serum Interleukin-31 Level and the Severity of Atopic Dermatitis in Children

Authors:

Atallah , Rabie Bedir | Amer , Ahmed Wahhed-Allah | Abd El-Samee , Hesham Samir | Ibraheem , Reham Mahmoud

Publisher:

Pan Arab League of Continuous Medical Education

Main Topics:

Medicine

Journal:

The Egyptian Journal of Hospital Medicine 2019 Vol.74 Issue 1, pp.156-161

Document Type:

Article

Publication Date:

1/2019

Document Language:

English

Document ID (Org No.):

131498

Frequency:

Quarterly

eISSN:

20907125

pISSN:

16872002

Descriptors:

Keywords:

Abstract:

 Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease, characterized by intense itch, typical localization and a specific image of skin lesions. Pathogenesis of pruritus in AD is not fully understood, but recent studies emphasize the role of interleukin-31 (IL-31). This relatively recently described cytokine is considered to be a potential mediator inducing pruritus in AD.Aim of the Work: was to assess the correlation of serum IL-31 level and the disease severity in children with AD.Patients and Methods: a case control study. Sera were obtained from 50 AD children and 30 healthy volunteers. IL-31 levels were measured using ELISA with standard kits from EIAab R&D Systems. Serum IL-31 levels were correlated with AD disease activity. Disease severity in children with AD was assessed using the SCORAD (Severity scoringof atopic dermatitis) index.Results: Serum IL-31 level was significantly higher in AD children (Mean ± SD 99.73 ± 75.93) than in healthy children (Mean ± SD 54.01 ± 57.36), (p-value = 0.019). Serum IL-31 levels correlated positively with the calculated severity score (SCORAD index), (rs = 0.480, p- value <0.001)Conclusion: The results of this study confirm the importance of IL-31 in AD pathophysiology. Serum IL-31 level is an objective reliable marker of AD severity in children. It may represent a novel target for antipruritic drug development.

Article Details

Correlation between Serum Interleukin-31 Level and the Severity of Atopic Dermatitis in Children

Authors:

Atallah , Rabie Bedir | Amer , Ahmed Wahhed-Allah | Abd El-Samee , Hesham Samir | Ibraheem , Reham Mahmoud

Publisher:

Pan Arab League of Continuous Medical Education

Main Topics:

Medicine

Journal:

The Egyptian Journal of Hospital Medicine 2019 Vol.74 Issue 1, pp.156-161

Document Type:

Article

Publication Date:

1/2019

Document Language:

English

Document ID (Org No.):

131498

Frequency:

Quarterly

eISSN:

20907125

pISSN:

16872002

Descriptors:

DERMATITIS

SKIN DISEASES

CHRONIC DISEASES

PAEDIATRICS

CHILDREN

PATIENTS

Atopic Dermatitis

Interleukin-31

Severity SCORAD

Pruritus

Children

Issues

Article Details

Authors: Atallah , Rabie Bedir | Amer , Ahmed Wahhed-Allah | Abd El-Samee , Hesham Samir | Ibraheem , Reham Mahmoud

Publisher: Pan Arab League of Continuous Medical Education

Main Topics: Medicine

Journal: The Egyptian Journal of Hospital Medicine 2019 Vol.74 Issue 1, pp.156-161

Document Type: Article

Publication Date: 1/2019

Document Language: English

Document ID (Org No.): 131498

Frequency: Quarterly

eISSN: 20907125

pISSN: 16872002

Descriptors:

Issues

Authors:

Atallah , Rabie Bedir | Amer , Ahmed Wahhed-Allah | Abd El-Samee , Hesham Samir | Ibraheem , Reham Mahmoud

Publisher:

Pan Arab League of Continuous Medical Education

Main Topics:

Medicine

Journal:

The Egyptian Journal of Hospital Medicine 2019 Vol.74 Issue 1, pp.156-161

Document Type:

Article

Publication Date:

1/2019

Document Language:

English

Document ID (Org No.):

131498

Frequency:

Quarterly

eISSN:

20907125

pISSN:

16872002