Altered thyroid function in small for gestational age newborns: study based on screening test for congenital hypothyroidism

Franco BAGNOLI; Laura FARMESCHI; Luana PERUZZI; Antonietta MUSARÃƒ'; Patrizia PAFFETTI; Silvia BADII; Martina CASUCCI; Letizia PASQUI; Francesca LACOPONI

Article Details

Altered thyroid function in small for gestational age newborns: study based on screening test for congenital hypothyroidism

Authors:

Franco BAGNOLI | Laura FARMESCHI | Luana PERUZZI | Antonietta MUSARÃƒ' | Patrizia PAFFETTI | Silvia BADII | Martina CASUCCI | Letizia PASQUI | Francesca LACOPONI

Publisher:

Bilal YILDIZ

Journal:

Journal of Pediatric Sciences 2010 Vol.2 Issue 4

Document Type:

Article

Publication Date:

9/2010

Document Language:

English

Document ID (Org No.):

2000743657

Frequency:

Bi-Annual

eISSN:

1309-1247

Abstract:

 

Background and Aims:  Unequivocal data is not yet available on alterations in plasma concentrations of thyroid hormones that may characterize small-for-gestational-age (SGA) newborns.  We used data from screening for congenital hypothyroidism in a large population to evaluate the relationship between growth restriction and thyroid function in the first week of life. 
Materials and Methods: Subjects: 14,092 newborns (13,333 appropriate-for-gestational-age (AGA) and 759 SGA) screened for congenital hypothyroidism on the third day of life.  The screening test measured plasma concentrations of TSH and T4 by fluoroimmunoenzyme assay.
Results: Comparison of SGA and AGA newborns revealed lower serum concentrations of T4 in preterm and term SGA infants (p=0.0001), whereas concentrations of TSH were significantly higher only in term SGA infants (p=0.0001).  T4 concentrations were positively correlated with gestational age in SGA and AGA groups, whereas TSH concentrations were only correlated with gestational age in the AGA group.  1.84% of SGA babies were recalled for TSH and T4 anomalies against only 0.93% of AGA newborns (p=0.01).
Conclusion: SGA babies had a higher incidence of transient hypothyroidism and required accurate follow-up and close monitoring of thyroid function.

Article Details

Altered thyroid function in small for gestational age newborns: study based on screening test for congenital hypothyroidism

Authors: Franco BAGNOLI | Laura FARMESCHI | Luana PERUZZI | Antonietta MUSARÃƒ' | Patrizia PAFFETTI | Silvia BADII | Martina CASUCCI | Letizia PASQUI | Francesca LACOPONI

Publisher: Bilal YILDIZ

Journal: Journal of Pediatric Sciences 2010 Vol.2 Issue 4

Document Type: Article

Publication Date: 9/2010

Document Language: English

Document ID (Org No.): 2000743657

Frequency: Bi-Annual

eISSN: 1309-1247

Issues

Authors:

Franco BAGNOLI | Laura FARMESCHI | Luana PERUZZI | Antonietta MUSARÃƒ' | Patrizia PAFFETTI | Silvia BADII | Martina CASUCCI | Letizia PASQUI | Francesca LACOPONI

Publisher:

Bilal YILDIZ

Journal:

Journal of Pediatric Sciences 2010 Vol.2 Issue 4

Document Type:

Article

Publication Date:

9/2010

Document Language:

English

Document ID (Org No.):

2000743657

Frequency:

Bi-Annual

eISSN:

1309-1247