Ethnopharmacological Survey on Phlomis grandiflora: in vivo Antihemorrhoidal Model

Ceylan DÖNMEZ; Ufuk KOCA ÇALIŞKAN

doi:https://doi.org/10.38093/cupmap.596972

Article Details

Ethnopharmacological Survey on Phlomis grandiflora: in vivo Antihemorrhoidal Model

Authors:

Ceylan DÖNMEZ | Ufuk KOCA ÇALIŞKAN

Publisher:

Nazım ŞEKEROĞLU

Journal:

Current Perspectives on Medicinal and Aromatic Plants 2019 Vol.2 Issue 1, pp.40-46

Document Type:

Article

Publication Date:

7/2019

Document Language:

English

Document ID (Org No.):

2000925628

Frequency:

Bi-Annual

eISSN:

2667-5722

pISSN:

2619-9645

DOI:

https://doi.org/10.38093/cupmap.596972

Abstract:

 


Phlomis grandiflora H.S Thompson
var. grandiflora, belongs to
Lamiaceae family, has been utilized traditionally for the treatment of wound,
inflammation, ulcer, diabetes and hemorrhoid mostly. Though hemorrhoids are so
widespread in the world, studies on the prevention and treatment with natural
pharmaceutical preparations of them are quite limited. People, who suffer from
hemorrhoids, tries variety of self treatment methods such as utilizing animal
products and homemade herbal preparations. Aim of this study is to evaluate the
ethnopharmacological application of P.
grandiflora on antihemorrhoidal activity of the leaf methanolic extract,
which was applied topically (50 % cream) for 7 days onto rats having croton
oil-induced hemorrhoid. Changes in the biochemical parameters such as TNF-α and VEGF showed that the plant extract
is slightly more effective at healing hemorrhoids compared to the reference preparation.
This is the first report revealing that the methanolic leaf extract of P. grandiflora showed topical antihemorrhoidal
activity. When chemical studies are taken into consideration, it has been
concluded that the plant extract containing a significant level of phenolic
compounds, might be a promising source for the investigation of the antihemorrhoidal
effect of medicinal plants, in the means of P.
grandiflora, and related disturbances.


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Article Details

Ethnopharmacological Survey on Phlomis grandiflora: in vivo Antihemorrhoidal Model

Authors: Ceylan DÖNMEZ | Ufuk KOCA ÇALIŞKAN

Publisher: Nazım ŞEKEROĞLU

Journal: Current Perspectives on Medicinal and Aromatic Plants 2019 Vol.2 Issue 1, pp.40-46

Document Type: Article

Publication Date: 7/2019

Document Language: English

Document ID (Org No.): 2000925628

Frequency: Bi-Annual

eISSN: 2667-5722

pISSN: 2619-9645

DOI: https://doi.org/10.38093/cupmap.596972

Issues

Authors:

Ceylan DÖNMEZ | Ufuk KOCA ÇALIŞKAN

Publisher:

Nazım ŞEKEROĞLU

Journal:

Current Perspectives on Medicinal and Aromatic Plants 2019 Vol.2 Issue 1, pp.40-46

Document Type:

Article

Publication Date:

7/2019

Document Language:

English

Document ID (Org No.):

2000925628

Frequency:

Bi-Annual

eISSN:

2667-5722

pISSN:

2619-9645

DOI:

https://doi.org/10.38093/cupmap.596972