The metabolites of ellagitannin metabolism urolithins display various biological activities

Jale YUZUGULEN; Bahareh NOSHADİ; Karar SHUKUR; Mustafa Fethi SAHİN; Hayrettin Ozan GULCAN

Article Details

The metabolites of ellagitannin metabolism urolithins display various biological activities

Authors:

Jale YUZUGULEN | Bahareh NOSHADİ | Karar SHUKUR | Mustafa Fethi SAHİN | Hayrettin Ozan GULCAN

Publisher:

Dogu Akdeniz University

Main Topics:

Pharmacology and therapeutics

Journal:

EMU Journal of Pharmaceutical Sciences 2019 Vol.2 Issue 2, pp.102-110

Document Type:

Article

Publication Date:

12/2019

Document Language:

English

Document ID (Org No.):

2000697693

Frequency:

Tri-annual

pISSN:

2651-3587

Abstract:

 


Dietary consumption to various nuts, berries, and particularly
pomegranate is an important source of ellagitannins. These molecules are
particularly subject to gastrointestinal metabolism producing urolithins as their
metabolites. Urolithins (i.e., hydroxylated benzo[c]chromen-6-one analogues) have
a greater absorption than the ellagitannins thus; greater bioavailability is of
great significance. Therefore, the biological activities obtained through the use
of ellagitannin rich foods are mainly attributed tourolithins. These compounds
possess a good peripheral distribution. In addition, some of their further
metabolitescan penetrate to the central nervous system which, is of a topic of
interest for CNS related pathologies. This review has aimed to introduce the
structure and metabolism related formation of different urolithins concomitant
to their biological activities discovered so far in the literature.



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Article Details

The metabolites of ellagitannin metabolism urolithins display various biological activities

Authors: Jale YUZUGULEN | Bahareh NOSHADİ | Karar SHUKUR | Mustafa Fethi SAHİN | Hayrettin Ozan GULCAN

Publisher: Dogu Akdeniz University

Main Topics: Pharmacology and therapeutics

Journal: EMU Journal of Pharmaceutical Sciences 2019 Vol.2 Issue 2, pp.102-110

Document Type: Article

Publication Date: 12/2019

Document Language: English

Document ID (Org No.): 2000697693

Frequency: Tri-annual

pISSN: 2651-3587

Issues

Authors:

Jale YUZUGULEN | Bahareh NOSHADİ | Karar SHUKUR | Mustafa Fethi SAHİN | Hayrettin Ozan GULCAN

Publisher:

Dogu Akdeniz University

Main Topics:

Pharmacology and therapeutics

Journal:

EMU Journal of Pharmaceutical Sciences 2019 Vol.2 Issue 2, pp.102-110

Document Type:

Article

Publication Date:

12/2019

Document Language:

English

Document ID (Org No.):

2000697693

Frequency:

Tri-annual

pISSN:

2651-3587