Reduction Behavior of Moxifloxacin Hydrocholaride and Its Analysis in Spiked Human Urine and Dosage Form by Voltammetry

Burcu TEPELİ; Selehattin YİLMAZ; Sultan YAGMUR

doi:https://doi.org/10.17350/HJSE19030000141

Article Details

Reduction Behavior of Moxifloxacin Hydrocholaride and Its Analysis in Spiked Human Urine and Dosage Form by Voltammetry

Authors:

Burcu TEPELİ | Selehattin YİLMAZ | Sultan YAGMUR

Publisher:

Hitit University

Journal:

Hittite Journal of Science and Engineering 2019 Vol.6 Issue 2, pp.153-156

Document Type:

Article

Publication Date:

6/2019

Document Language:

English

Document ID (Org No.):

2000451589

Frequency:

Quarterly

eISSN:

2148-4171

DOI:

https://doi.org/10.17350/HJSE19030000141

Abstract:

 

A voltammetric method was developed to analyze moxifloxacin hydrochloride  MoxHCl  in pharmaceutical preparations and spiked human urine. The experimental measurements were completed using different buffer systems  pH 0.50- 12.05  on Glassy Carbon Electrode  GCE  with differential pulse voltammetry  DPV  and Cyclic Voltammetry  CV  methods. The effect of pH on the peak current and potential were determined. Britton-Robinson  BR  buffer  pH 7.00  was used for analysis. The peak was established to be diffusion-controlled based on the nature of electrode. Calibration plots were prepared for the concentration range from 3×10-4 M to 1.1×10-3 M with DPV. Limits of detection  LOD  and quantification  LOQ  were calculated as 5.1×10-5 M and 2.30×10-4 M, respectively. The validation of the applied methods was completed. Electroreduction mechanism was proposed.

Article Details

Reduction Behavior of Moxifloxacin Hydrocholaride and Its Analysis in Spiked Human Urine and Dosage Form by Voltammetry

Authors: Burcu TEPELİ | Selehattin YİLMAZ | Sultan YAGMUR

Publisher: Hitit University

Journal: Hittite Journal of Science and Engineering 2019 Vol.6 Issue 2, pp.153-156

Document Type: Article

Publication Date: 6/2019

Document Language: English

Document ID (Org No.): 2000451589

Frequency: Quarterly

eISSN: 2148-4171

DOI: https://doi.org/10.17350/HJSE19030000141

Issues

Authors:

Burcu TEPELİ | Selehattin YİLMAZ | Sultan YAGMUR

Publisher:

Hitit University

Journal:

Hittite Journal of Science and Engineering 2019 Vol.6 Issue 2, pp.153-156

Document Type:

Article

Publication Date:

6/2019

Document Language:

English

Document ID (Org No.):

2000451589

Frequency:

Quarterly

eISSN:

2148-4171

DOI:

https://doi.org/10.17350/HJSE19030000141