Geri Çekildi:
                                                                                The effects of Vitamin D levels on pregnancy outcomes in patients receiving frozen embryo transfer

Merve Çakır Köle; Emre Köle; Gökşen Görgülü; Barış Candan; Ahmet Güllüoğlu; Emek Doğer; Lale Aksoy

Article Details

Geri Çekildi: The effects of Vitamin D levels on pregnancy outcomes in patients receiving frozen embryo transfer

Authors:

Merve Çakır Köle | Emre Köle | Gökşen Görgülü | Barış Candan | Ahmet Güllüoğlu | Emek Doğer | Lale Aksoy

Publisher:

Kocaeli University

Main Topics:

Kadın Hastalıkları ve Doğum

Journal:

Acta Medica Nicomedia Vol.6 Issue 1, pp.38-43

Document Type:

Article

Publication Date:

2/2023

Document Language:

English

Document ID (Org No.):

2001284613

pISSN:

2717-8994

Keywords:

Abstract:

 Objective: The aim of this study is to evaluate the effects of 25-OH vitamin D on pregnancy outcomes in infertile patients undergoing a frozen embryo transfer. Methods: In this prospective, single-blind study conducted at Kocaeli University Medical Faculty Hospital, Center for Assisted Reproductive Techniques, baseline serum levels of 25-OH vitamin D were measured at the start of treatment in 276 infertile patients who were scheduled to undergo frozen embryo transfer FET. Cases with 25-OH-D vitamin levels lower than the level of deficiency 20 ngml, group A, n48 and higher than the level of deficiency 20 ngml, group B, n44 were compared in terms of the rates of pregnancy as an outcome of the FET cycle, clinical pregnancy, ongoing pregnancy, live birth, implantation, pregnancy loss, and multiple pregnancy. Results: Cases in groups 1 and 2 had similar demographic characteristics, and the serum AMH levels, one of the cycle follow-up parameters, were statistically significantly higher in group 1 compared to group 2 p0.014. Pregnancy 41.6 vs. 31.8, clinical pregnancy 35.4 vs. 25, ongoing pregnancy 25 vs. 18.2, live birth 20.8 vs. 18.2, pregnancy loss 18.8 vs. 13.6 and twin pregnancy 4.2 vs. 9.1 were similar between the groups p0.328, p0.278, p0.428, p0.749, p0.507, p0.421, respectively. Conclusion: There was no correlation between pregnancy outcomes from frozen embryo transfer and baseline serum 25-OH vitamin D levels obtained at the start of treatment. There is no indirect evidence showing that vitamin D level exerts its effects on fertility through endometrial receptivity and the implantation process.

 Objective: The aim of this study is to evaluate the effects of 25-OH vitamin D on pregnancy outcomes in infertile patients undergoing a frozen embryo transfer. Methods: In this prospective, single-blind study conducted at Kocaeli University Medical Faculty Hospital, Center for Assisted Reproductive Techniques, baseline serum levels of 25-OH vitamin D were measured at the start of treatment in 276 infertile patients who were scheduled to undergo frozen embryo transfer FET. Cases with 25-OH-D vitamin levels lower than the level of deficiency 20 ngml, group A, n48 and higher than the level of deficiency 20 ngml, group B, n44 were compared in terms of the rates of pregnancy as an outcome of the FET cycle, clinical pregnancy, ongoing pregnancy, live birth, implantation, pregnancy loss, and multiple pregnancy. Results: Cases in groups 1 and 2 had similar demographic characteristics, and the serum AMH levels, one of the cycle follow-up parameters, were statistically significantly higher in group 1 compared to group 2 p0.014. Pregnancy 41.6 vs. 31.8, clinical pregnancy 35.4 vs. 25, ongoing pregnancy 25 vs. 18.2, live birth 20.8 vs. 18.2, pregnancy loss 18.8 vs. 13.6 and twin pregnancy 4.2 vs. 9.1 were similar between the groups p0.328, p0.278, p0.428, p0.749, p0.507, p0.421, respectively. Conclusion: There was no correlation between pregnancy outcomes from frozen embryo transfer and baseline serum 25-OH vitamin D levels obtained at the start of treatment. There is no indirect evidence showing that vitamin D level exerts its effects on fertility through endometrial receptivity and the implantation process.

 Objective: The aim of this study is to evaluate the effects of 25-OH vitamin D on pregnancy outcomes in infertile patients undergoing a frozen embryo transfer. Methods: In this prospective, single-blind study conducted at Kocaeli University Medical Faculty Hospital, Center for Assisted Reproductive Techniques, baseline serum levels of 25-OH vitamin D were measured at the start of treatment in 276 infertile patients who were scheduled to undergo frozen embryo transfer FET. Cases with 25-OH-D vitamin levels lower than the level of deficiency 20 ngml, group A, n48 and higher than the level of deficiency 20 ngml, group B, n44 were compared in terms of the rates of pregnancy as an outcome of the FET cycle, clinical pregnancy, ongoing pregnancy, live birth, implantation, pregnancy loss, and multiple pregnancy. Results: Cases in groups 1 and 2 had similar demographic characteristics, and the serum AMH levels, one of the cycle follow-up parameters, were statistically significantly higher in group 1 compared to group 2 p0.014. Pregnancy 41.6 vs. 31.8, clinical pregnancy 35.4 vs. 25, ongoing pregnancy 25 vs. 18.2, live birth 20.8 vs. 18.2, pregnancy loss 18.8 vs. 13.6 and twin pregnancy 4.2 vs. 9.1 were similar between the groups p0.328, p0.278, p0.428, p0.749, p0.507, p0.421, respectively. Conclusion: There was no correlation between pregnancy outcomes from frozen embryo transfer and baseline serum 25-OH vitamin D levels obtained at the start of treatment. There is no indirect evidence showing that vitamin D level exerts its effects on fertility through endometrial receptivity and the implantation process.

 Amaç: Donmuş embriyo transferi yapılan infertil hastalarda 25-OH vitamin Dnin gebelik sonuçlarına etkisini değerlendirmek. Yöntem: Kocaeli Üniversitesi Tıp Fakültesi Hastanesi, Üremeye Yardımcı Teknikler Merkezinde prospektif -tek kör olarak yürütülen bu çalışmada donmuş embriyo transferi DET yapılması planlanan 276 infertil olgunun serum 25-OH vitamin D düzeyleri tedavi başlangıcında elde edildi. 25-OH-D vitamini seviyelerinin yetmezlik seviyesinde düşük olduğu olgular 20 ngml, grup A, n48 ve yetmezlik seviyesinin üstünde olduğu 20 ngml, grup B, n44 olgular DET siklusu sonucundaki gebelik, klinik gebelik, devam eden gebelik, canlı doğum, implantasyon, gebelik kaybı ve çoğul gebelik oranları karşılaştırıldı. Bulgular: Grup 1 ve grup 2 olguların demografik özellikleri benzerdi ve siklus takip parametrelerinden serum AMH düzeyleri grup 1 de grup 2 ye göre istatiksel olarak anlamlı yüksek izlenmiştir p0,014. Gruplar arasında gebelik  41,6 vs 31,8, klinik gebelik 35,4 vs 25, devam eden gebelik 25 vs 18,2, canlı doğum 20,8 vs 18,2, gebelik kaybı 18,8 vs 13,6 ve ikiz gebelik  4,2 vs  9,1 benzerdi sırasıyla; p 0,328 p 0.278, p 0,428, p 0,749, p 0,507, p 0,421 . Sonuç: Donmuş embriyo transferinden elde edilen gebelik sonuçları ile tedavi başlangıcında elde edilen serum 25-OH vitamin D seviyeleri arasında ilişki tespit edilmemiştir. Vitamin D seviyesinin fertilite üzerindeki etkilerini endometriyal reseptivite ve implantasyon süreci üzerinden gösterdiğine dair dolaylı kanıt elde edilmemiştir.

Article Details

Geri Çekildi: The effects of Vitamin D levels on pregnancy outcomes in patients receiving frozen embryo transfer

Authors:

Merve Çakır Köle | Emre Köle | Gökşen Görgülü | Barış Candan | Ahmet Güllüoğlu | Emek Doğer | Lale Aksoy

Publisher:

Kocaeli University

Main Topics:

Kadın Hastalıkları ve Doğum

Journal:

Acta Medica Nicomedia Vol.6 Issue 1, pp.38-43

Document Type:

Article

Publication Date:

2/2023

Document Language:

English

Document ID (Org No.):

2001284613

pISSN:

2717-8994

25-OH Vitamin D

Frozen embryo transfer

pregnancy outcome

Donmuş Embriyo Transferi

Gebelik Sonucu

25-OH Vitamin D

Issues

Article Details

Geri Çekildi: The effects of Vitamin D levels on pregnancy outcomes in patients receiving frozen embryo transfer

Authors: Merve Çakır Köle | Emre Köle | Gökşen Görgülü | Barış Candan | Ahmet Güllüoğlu | Emek Doğer | Lale Aksoy

Publisher: Kocaeli University

Main Topics: Kadın Hastalıkları ve Doğum

Journal: Acta Medica Nicomedia Vol.6 Issue 1, pp.38-43

Document Type: Article

Publication Date: 2/2023

Document Language: English

Document ID (Org No.): 2001284613

pISSN: 2717-8994

25-OH Vitamin D

Frozen embryo transfer

pregnancy outcome

Donmuş Embriyo Transferi

Gebelik Sonucu

25-OH Vitamin D

Issues

Authors:

Merve Çakır Köle | Emre Köle | Gökşen Görgülü | Barış Candan | Ahmet Güllüoğlu | Emek Doğer | Lale Aksoy

Publisher:

Kocaeli University

Main Topics:

Kadın Hastalıkları ve Doğum

Journal:

Acta Medica Nicomedia Vol.6 Issue 1, pp.38-43

Document Type:

Article

Publication Date:

2/2023

Document Language:

English

Document ID (Org No.):

2001284613

pISSN:

2717-8994