An update on Nanoparticle Formulation Design of Piperine to Improve its Oral bioavailability: A Review

Akhmad Kharis Nugroho; Nindya Kusumorini; Suwijiyo Pramono; Ronny Martien

doi:10.31351/vol32iss1pp14-30

Article Details

An update on Nanoparticle Formulation Design of Piperine to Improve its Oral bioavailability: A Review

Authors:

Akhmad Kharis Nugroho | Nindya Kusumorini | Suwijiyo Pramono | Ronny Martien

Publisher:

University of Baghdad

Journal:

Iraqi Journal of Pharmaceutical Sciences Vol.32 Issue 1, pp.14-30

Document Type:

Article

Publication Date:

6/2023

Document Language:

English

Document ID (Org No.):

2001363059

pISSN:

2521-3512

DOI:

10.31351/vol32iss1pp14-30

Keywords:

Abstract:

 Piperine, a crystalline alkaloid compound isolated from Piper nigrum, piper longum, and other types of piper, has had many fabulous pharmacological advantages for preventing and treating some specific diseases, such as analgesic, anti-inflammatory, hepatoprotective, antimetastatic, antithyroid, immunomodulatory, antitumor, rheumatoid arthritis, osteoarthritis, Alzheimer's, and improving the bioavailability of other drugs. However, its potential for clinical use through oral usage is hindered by water solubility and poor bioavailability. The low level of oral bioavailability is caused by low solubility in water and is photosensitive, susceptible to isomerization by UV light, which causes piperine concentration to decrease. Many different formulation approaches have been applied to improve the poor oral bioavailability of piperine. There have been oral formulation strategies that have been successfully implemented in increasing the solubility and bioavailability of piperine within the body, such as the formulation of nanoparticles, nanosuspensions, salt formation, liposomes, complexation using polymers, micro/nano-emulsions, and solid dispersions. This review presents a summary of piperine biopharmaceuticals, new formulation design approaches to improve oral bioavailability of piperine, and several techniques and methods for conducting selective and sensitive analysis of piperine in biological fluids.

Article Details

An update on Nanoparticle Formulation Design of Piperine to Improve its Oral bioavailability: A Review

Authors:

Akhmad Kharis Nugroho | Nindya Kusumorini | Suwijiyo Pramono | Ronny Martien

Publisher:

University of Baghdad

Journal:

Iraqi Journal of Pharmaceutical Sciences Vol.32 Issue 1, pp.14-30

Document Type:

Article

Publication Date:

6/2023

Document Language:

English

Document ID (Org No.):

2001363059

pISSN:

2521-3512

DOI:

10.31351/vol32iss1pp14-30

Review of orally formulation and pharmacokinetic analysis of piperine

piperine

bioavailability

solubility

formulation

pharmacokinetic

Issues

Article Details

An update on Nanoparticle Formulation Design of Piperine to Improve its Oral bioavailability: A Review

Authors: Akhmad Kharis Nugroho | Nindya Kusumorini | Suwijiyo Pramono | Ronny Martien

Publisher: University of Baghdad

Journal: Iraqi Journal of Pharmaceutical Sciences Vol.32 Issue 1, pp.14-30

Document Type: Article

Publication Date: 6/2023

Document Language: English

Document ID (Org No.): 2001363059

pISSN: 2521-3512

DOI: 10.31351/vol32iss1pp14-30

Review of orally formulation and pharmacokinetic analysis of piperine

piperine

bioavailability

solubility

formulation

pharmacokinetic

Issues

Authors:

Akhmad Kharis Nugroho | Nindya Kusumorini | Suwijiyo Pramono | Ronny Martien

Publisher:

University of Baghdad

Journal:

Iraqi Journal of Pharmaceutical Sciences Vol.32 Issue 1, pp.14-30

Document Type:

Article

Publication Date:

6/2023

Document Language:

English

Document ID (Org No.):

2001363059

pISSN:

2521-3512

DOI:

10.31351/vol32iss1pp14-30