Investigation of Inflammation Rates (Neutrophil/Lymphocyte) and Hemogram Results in the Stages of Non-Alcoholic Fatty Liver Disease

Mehmet Ali Gül; Duygu Tozcu Yılmaz; Mustafa Çapraz

Article Details

Investigation of Inflammation Rates (Neutrophil/Lymphocyte) and Hemogram Results in the Stages of Non-Alcoholic Fatty Liver Disease

Authors:

Mehmet Ali Gül | Duygu Tozcu Yılmaz | Mustafa Çapraz

Publisher:

Aydin Adnan Menderes University

Main Topics:

Biochemistry and Cell Biology (Other)

Journal:

Meandros Medical And Dental Journal Vol.26 Issue 1, pp.129-135

Document Type:

Article

Publication Date:

3/2025

Document Language:

English

Document ID (Org No.):

2001342934

pISSN:

2149-9063

Keywords:

Abstract:

 Introducton: Non-alcoholic fatty liver disease NAFLD is a chronic condition characterized by excessive fat accumulation in the liver accompanied by inflammation. This study aims to know the diagnostic value of NLR in stages of NAFLD Methods: A retrospective case-control study was conducted, including 49 NAFLD patients with NAFLD Grade 1, 48 with NAFLD Grade 2, 52 with NAFLD Grade 3, and 103 healthy control HC individuals. NeutrophilLymphocyte ratios as well as RBC, HGB, HCT, MCHC, MPV, WBC, MCV, MCH, PLT, RDW-SD, RDW-CV, PDW, PCT, NEUT, LYMPH, NLR, MONO, EO, BASO values were examined. Results: As the disease stages progressed G3, a significant decrease p0.005 in MPV values and a significant increase p0.05 in NLR values were observed. No statistically significant difference was found between the groups in RBC p0.061, HCT p0.097, MCHC p0.747, MCV p0.05, MCH p0.05, PDW p0.05, PCT p0.05, MONO p0.05 and EO p0.05 parameters. Conclusion: MPV and NLR may be considered as effective biomarkers for monitoring the progression of NAFLD and evaluating the inflammatory status of patients.

 Introducton: Non-alcoholic fatty liver disease NAFLD is a chronic condition characterized by excessive fat accumulation in the liver accompanied by inflammation. This study aims to know the diagnostic value of NLR in stages of NAFLD Methods: A retrospective case-control study was conducted, including 49 NAFLD patients with NAFLD Grade 1, 48 with NAFLD Grade 2, 52 with NAFLD Grade 3, and 103 healthy control HC individuals. NeutrophilLymphocyte ratios as well as RBC, HGB, HCT, MCHC, MPV, WBC, MCV, MCH, PLT, RDW-SD, RDW-CV, PDW, PCT, NEUT, LYMPH, NLR, MONO, EO, BASO values were examined. Results: As the disease stages progressed G3, a significant decrease p0.005 in MPV values and a significant increase p0.05 in NLR values were observed. No statistically significant difference was found between the groups in RBC p0.061, HCT p0.097, MCHC p0.747, MCV p0.05, MCH p0.05, PDW p0.05, PCT p0.05, MONO p0.05 and EO p0.05 parameters. Conclusion: MPV and NLR may be considered as effective biomarkers for monitoring the progression of NAFLD and evaluating the inflammatory status of patients.

 Introducton: Non-alcoholic fatty liver disease NAFLD is a chronic condition characterized by excessive fat accumulation in the liver accompanied by inflammation. This study aims to know the diagnostic value of NLR in stages of NAFLD Methods: A retrospective case-control study was conducted, including 49 NAFLD patients with NAFLD Grade 1, 48 with NAFLD Grade 2, 52 with NAFLD Grade 3, and 103 healthy control HC individuals. NeutrophilLymphocyte ratios as well as RBC, HGB, HCT, MCHC, MPV, WBC, MCV, MCH, PLT, RDW-SD, RDW-CV, PDW, PCT, NEUT, LYMPH, NLR, MONO, EO, BASO values were examined. Results: As the disease stages progressed G3, a significant decrease p0.005 in MPV values and a significant increase p0.05 in NLR values were observed. No statistically significant difference was found between the groups in RBC p0.061, HCT p0.097, MCHC p0.747, MCV p0.05, MCH p0.05, PDW p0.05, PCT p0.05, MONO p0.05 and EO p0.05 parameters. Conclusion: MPV and NLR may be considered as effective biomarkers for monitoring the progression of NAFLD and evaluating the inflammatory status of patients.

 Giriş: Non-alkolik yağlı karaciğer hastalığı NAYKH, karaciğerde anormal düzeyde yağ birikimi ve buna eşlik eden enflamasyonla karakterize kronik bir durumdur. Bu çalışmanın amacı NAYKH evrelerinde ve sağlıklı bireylerde NLRnin tanı değerini araştırmaktır. Yöntem: NAYKH Evre 1li 49 NAYKH hasta, NAYKH Evre 2li 48 hasta, NAYKH Evre 3lü 52 hasta ve 103 sağlıklı kontrol bireyi içeren retrospektif bir vaka kontrol çalışması olarak yürütüldü. NötrofilLenfosit oranları ve RBC, HGB, HCT, MCHC, MPV, WBC, NEUT, RDW-CV, BASO, MCH, LYMPH, PDW, PCT, NLR, EO, RDW-SD, MONO, PLT, MCV değerleri incelendi. Bulgular: Hastalık evreleri ilerledikçe G3, MPV değerlerinde anlamlı bir azalma p0,005 ve NLR değerlerinde anlamlı bir artış p0,05 gözlendi. Gruplar arasında RBC p0,061, HCT p0,097, MCHC p0,747, MCV p0,05, MCH p0,05, PDW p0,05, PCT p0,05, MONO p0,05 ve EO p0,05 parametrelerinde istatistiksel olarak anlamlı bir fark bulunmamıştır. Sonuç: MPV ve NLR, NAYKHnin ilerlemesini izlemek ve hastaların inflamatuar durumunu değerlendirmek için etkili biyobelirteçler olarak düşünülebilir.

Article Details

Investigation of Inflammation Rates (Neutrophil/Lymphocyte) and Hemogram Results in the Stages of Non-Alcoholic Fatty Liver Disease

Authors:

Mehmet Ali Gül | Duygu Tozcu Yılmaz | Mustafa Çapraz

Publisher:

Aydin Adnan Menderes University

Main Topics:

Biochemistry and Cell Biology (Other)

Journal:

Meandros Medical And Dental Journal Vol.26 Issue 1, pp.129-135

Document Type:

Article

Publication Date:

3/2025

Document Language:

English

Document ID (Org No.):

2001342934

pISSN:

2149-9063

Non-Alcoholic Fatty Liver Disease

Neutrophil

LymphocyteAlkole bağlı olmayan yağlı karaciğer hastalığı

Nötrofil lenfosit oranı

Ortalama trombosit hacmi.

Issues

Article Details

Investigation of Inflammation Rates (Neutrophil/Lymphocyte) and Hemogram Results in the Stages of Non-Alcoholic Fatty Liver Disease

Authors: Mehmet Ali Gül | Duygu Tozcu Yılmaz | Mustafa Çapraz

Publisher: Aydin Adnan Menderes University

Main Topics: Biochemistry and Cell Biology (Other)

Journal: Meandros Medical And Dental Journal Vol.26 Issue 1, pp.129-135

Document Type: Article

Publication Date: 3/2025

Document Language: English

Document ID (Org No.): 2001342934

pISSN: 2149-9063

Non-Alcoholic Fatty Liver Disease

Neutrophil

LymphocyteAlkole bağlı olmayan yağlı karaciğer hastalığı

Nötrofil lenfosit oranı

Ortalama trombosit hacmi.

Issues

Authors:

Mehmet Ali Gül | Duygu Tozcu Yılmaz | Mustafa Çapraz

Publisher:

Aydin Adnan Menderes University

Main Topics:

Biochemistry and Cell Biology (Other)

Journal:

Meandros Medical And Dental Journal Vol.26 Issue 1, pp.129-135

Document Type:

Article

Publication Date:

3/2025

Document Language:

English

Document ID (Org No.):

2001342934

pISSN:

2149-9063