Intralesional epidermal growth factor treatment on diabetic foot ulcers: one centre experience

Aydın ÇİFCİ; Birhan OKTAŞ; Şenay ARIKAN DURMAZ; Aşkın GÜNGÜNEŞ; İrfan KARAHAN; Taner SARAK

doi:https://doi.org/10.32322/jhsm.397000

Article Details

Intralesional epidermal growth factor treatment on diabetic foot ulcers: one centre experience

Authors:

Aydın ÇİFCİ | Birhan OKTAŞ | Şenay ARIKAN DURMAZ | Aşkın GÜNGÜNEŞ | İrfan KARAHAN | Taner SARAK

Publisher:

MediHealth Academy Yayıncılık

Main Topics:

Promotion of health

Journal:

Journal of Health Sciences and Medicine 2018 Vol.1 Issue 1, pp.1-3

Document Type:

Article

Publication Date:

4/2018

Document Language:

English

Document ID (Org No.):

2000482567

Frequency:

Bimonthly

eISSN:

2636-8579

DOI:

https://doi.org/10.32322/jhsm.397000

Abstract:

 


Introduction:
The intralesional injection of
recombinant human epidermal growth factor (EGF-IL) is a new approach for
reducing amputations. In this study we aimed to show efficacy of EGF-IL with
cases.Material and Method: EGF-IL 75 μg application to 8 diabetic foot ulcers
(6 males, 2 females; mean age: 60.3±9.3 years) was evaluated. Patients had
history of prior standard treatments.Results:  In all
eight patients’ completely healing was observed diabetic foot ulcers after the
intralesional EGF treatment.





Conclusion: In our experience our patients’
wounds wish priorly have healing problems, improved with intralesional EGF.
This treatment is expensive and caused of some allergic reactions. Relation
with malignancies are not known for long-term. 


.

 


Giriş: Rekombinant insan epidermal
büyüme faktörü (EGF-IL) intralezyonel enjeksiyonu amputasyonları azaltmak için
yeni bir yaklaşımdır. Bu çalışmada EGF-IL'nin olgularla etkinliğini göstermeyi
amaçladık.


Gereç ve Yöntem: Sekiz diyabetik ayak ülserine (6
erkek, 2 kadın; ortalama yaş: 60.3 ± 9.3 yıl) EGF-IL 75 μg uygulandı. Hastalar
daha önce standart tedaviler geçmişi vardı.


Bulgular: Sekiz hastanın tamamında,
intralezyonel EGF tedavisinden sonra diyabetik ayak ülserleri iyileşti.









Sonuç: Tecrübelerimize göre,
hastalarımızın yaraları önceden intralezyonal EGF ile iyileşen iyileşme
problemlerine sahip olmak istemektedir. Bu tedavi pahalıdır ve bazı alerjik
reaksiyonlara neden olur. Malignitelerle olan ilişki uzun süredir
bilinmemektedir.


.

Article Details

Intralesional epidermal growth factor treatment on diabetic foot ulcers: one centre experience

Authors: Aydın ÇİFCİ | Birhan OKTAŞ | Şenay ARIKAN DURMAZ | Aşkın GÜNGÜNEŞ | İrfan KARAHAN | Taner SARAK

Publisher: MediHealth Academy Yayıncılık

Main Topics: Promotion of health

Journal: Journal of Health Sciences and Medicine 2018 Vol.1 Issue 1, pp.1-3

Document Type: Article

Publication Date: 4/2018

Document Language: English

Document ID (Org No.): 2000482567

Frequency: Bimonthly

eISSN: 2636-8579

DOI: https://doi.org/10.32322/jhsm.397000

Issues

Authors:

Aydın ÇİFCİ | Birhan OKTAŞ | Şenay ARIKAN DURMAZ | Aşkın GÜNGÜNEŞ | İrfan KARAHAN | Taner SARAK

Publisher:

MediHealth Academy Yayıncılık

Main Topics:

Promotion of health

Journal:

Journal of Health Sciences and Medicine 2018 Vol.1 Issue 1, pp.1-3

Document Type:

Article

Publication Date:

4/2018

Document Language:

English

Document ID (Org No.):

2000482567

Frequency:

Bimonthly

eISSN:

2636-8579

DOI:

https://doi.org/10.32322/jhsm.397000