Synthesis and Characterization of New Phthalimides Containing 1, 2, 4-triazole and Imine Group

Khalid F. Ali; Eman M. Hussain; Rana S. Ahmed

Article Details

Synthesis and Characterization of New Phthalimides Containing 1, 2, 4-triazole and Imine Group

Authors:

Khalid F. Ali | Eman M. Hussain | Rana S. Ahmed

Publisher:

University of Baghdad

Journal:

Ibn AL-Haitham Journal For Pure and Applied Sciences Vol.28 Issue 2, pp.86-101

Document Type:

Article

Publication Date:

1/2015

Document Language:

English

Document ID (Org No.):

2001377323

pISSN:

2521-3407

Keywords:

Abstract:

 Several new derivatives of 1, 2, 4-triazoles linked to phthalimide moiety were synthesized through following multisteps. The first step involved preparation of 2, 2-diphthalimidyl ethanoic acid [2] via reaction of two moles of phthalimide with dichloroacetic acid. Treatment of the resulted imide with ethanol in the second step afforded 2,2-diphthalimidyl ester[3] which inturn was introduced in reaction with hydrazine hydrate in the third step ,producing the corresponding hydrazide derivative[4] .The synthesized hydazide  was introduced in different synthetic paths including treatment with carbon disulfide in alkaline solution then with hydrazine hydrate to afford the new 1,2,4-triazole[10] .Reaction of compound [10] with different aldehydes produced a new Schiff base derivatives[11,12] .Reaction of derivative [4] with different aldehydes produced a new derivatives [5-8].All the synthesized compounds have been characterized by melting points ,FTIR ,1HNMR(some of them ) and mass spectroscopy of compound [2]. Derivatives [5, 6, 7, 10, 11, 12] were tested against inhibition of E-coli, staphyloccus aureus  and were all  found  to be active. Schem1,2 illustrated the reaction steps.

Article Details

Synthesis and Characterization of New Phthalimides Containing 1, 2, 4-triazole and Imine Group

Authors:

Khalid F. Ali | Eman M. Hussain | Rana S. Ahmed

Publisher:

University of Baghdad

Journal:

Ibn AL-Haitham Journal For Pure and Applied Sciences Vol.28 Issue 2, pp.86-101

Document Type:

Article

Publication Date:

1/2015

Document Language:

English

Document ID (Org No.):

2001377323

pISSN:

2521-3407

synthesis

imide

1

3

4-triazole

Schiff bases

Issues

Article Details

Synthesis and Characterization of New Phthalimides Containing 1, 2, 4-triazole and Imine Group

Authors: Khalid F. Ali | Eman M. Hussain | Rana S. Ahmed

Publisher: University of Baghdad

Journal: Ibn AL-Haitham Journal For Pure and Applied Sciences Vol.28 Issue 2, pp.86-101

Document Type: Article

Publication Date: 1/2015

Document Language: English

Document ID (Org No.): 2001377323

pISSN: 2521-3407

synthesis

imide

1

3

4-triazole

Schiff bases

Issues

Authors:

Khalid F. Ali | Eman M. Hussain | Rana S. Ahmed

Publisher:

University of Baghdad

Journal:

Ibn AL-Haitham Journal For Pure and Applied Sciences Vol.28 Issue 2, pp.86-101

Document Type:

Article

Publication Date:

1/2015

Document Language:

English

Document ID (Org No.):

2001377323

pISSN:

2521-3407