Association of Single-Nucleotide Polymorphism (rs833061) of Vascular Endothelial Growth Factor with Breast Cancer Risk

Saad , Wessam El Sayed; Osman , Mona Mostafa; Mahmoud , Manal Abdel Baky; Hassan , Safeya Hamdy Zakaria; Abou Zaghla , Heba M. Adel

Article Details

Association of Single-Nucleotide Polymorphism (rs833061) of Vascular Endothelial Growth Factor with Breast Cancer Risk

Authors:

Saad , Wessam El Sayed | Osman , Mona Mostafa | Mahmoud , Manal Abdel Baky | Hassan , Safeya Hamdy Zakaria | Abou Zaghla , Heba M. Adel

Publisher:

Pan Arab League of Continuous Medical Education

Main Topics:

Medicine

Journal:

The Egyptian Journal of Hospital Medicine 2020 Vol.80 Issue 3, pp.1014-1018

Document Type:

Article

Publication Date:

7/2020

Document Language:

English

Document ID (Org No.):

142553

Frequency:

Quarterly

eISSN:

20907125

pISSN:

16872002

Descriptors:

Keywords:

Abstract:

 Background: Breast cancer is the most common cancer among women and one of the most important causes of deathamong them. Angiogenesis is an important step for primary tumor growth, invasiveness, and metastases. Vascularendothelial growth factor (VEGF) is involved in angiogenesis associated with tumors.Objective: To investigate the association of single nucleotide polymorphisms (SNPs) of VEGF gene located in thepromoter region at position 460T/C (rs833061) with the risk of breast cancer.Patients and Methods: This study was conducted on (40) Egyptian female patients who were diagnosed as breast canceraccording to histopathological examination of breast biopsy (Group 1, Patients), in addition to (40) age-matchedapparently healthy females serving as controls (Group II, Controls). Detection of SNP of VEGF gene located in thepromoter region 460T/C (rs833061) was done by real-time polymerase chain reaction technique.Results: There was no significant difference in frequency of the (C/C, T/C and T/T) genotypes of VEGF 460T/C(rs833061) in group I compared with group II (p>0.05). None of the studied VEGF genotypes had shown significantdifference in distribution related to clinico-pathological parameters as tumor size, histological grade, hormone receptors,HER2/new status, regional lymph node and distant metastasis (p>0.05).Conclusion: This study revealed that there was no significant association of the (C/C, T/C and T/T) genotypes of VEGF460T/C (rs833061) and breast cancer risk. Moreover, VEGF polymorphism 460T/C (rs833061) was not associated withbreast cancer patients’ clinico-pathological characteristics and tumor markers levels.

Article Details

Association of Single-Nucleotide Polymorphism (rs833061) of Vascular Endothelial Growth Factor with Breast Cancer Risk

Authors:

Saad , Wessam El Sayed | Osman , Mona Mostafa | Mahmoud , Manal Abdel Baky | Hassan , Safeya Hamdy Zakaria | Abou Zaghla , Heba M. Adel

Publisher:

Pan Arab League of Continuous Medical Education

Main Topics:

Medicine

Journal:

The Egyptian Journal of Hospital Medicine 2020 Vol.80 Issue 3, pp.1014-1018

Document Type:

Article

Publication Date:

7/2020

Document Language:

English

Document ID (Org No.):

142553

Frequency:

Quarterly

eISSN:

20907125

pISSN:

16872002

Descriptors:

BREAST CANCER

POLYMORPHISM

NUCLEOTIDES

ENDOTHELIAL CELLS

Breast Cancer

SNP

VEGF Polymorphism 460T/C

Issues

Article Details

Authors: Saad , Wessam El Sayed | Osman , Mona Mostafa | Mahmoud , Manal Abdel Baky | Hassan , Safeya Hamdy Zakaria | Abou Zaghla , Heba M. Adel

Publisher: Pan Arab League of Continuous Medical Education

Main Topics: Medicine

Journal: The Egyptian Journal of Hospital Medicine 2020 Vol.80 Issue 3, pp.1014-1018

Document Type: Article

Publication Date: 7/2020

Document Language: English

Document ID (Org No.): 142553

Frequency: Quarterly

eISSN: 20907125

pISSN: 16872002

Descriptors:

Issues

Authors:

Saad , Wessam El Sayed | Osman , Mona Mostafa | Mahmoud , Manal Abdel Baky | Hassan , Safeya Hamdy Zakaria | Abou Zaghla , Heba M. Adel

Publisher:

Pan Arab League of Continuous Medical Education

Main Topics:

Medicine

Journal:

The Egyptian Journal of Hospital Medicine 2020 Vol.80 Issue 3, pp.1014-1018

Document Type:

Article

Publication Date:

7/2020

Document Language:

English

Document ID (Org No.):

142553

Frequency:

Quarterly

eISSN:

20907125

pISSN:

16872002