Comparative effects of levosimendan and dobutamine infusion on p wave dispersion in patients with acute decompensated heart failure

Atila İYİSOY; Turgay ÇELİK; Murat ÇELİK; Barış BUĞAN; Halil YAMAN

Article Details

Comparative effects of levosimendan and dobutamine infusion on p wave dispersion in patients with acute decompensated heart failure

Authors:

Atila İYİSOY | Turgay ÇELİK | Murat ÇELİK | Barış BUĞAN | Halil YAMAN

Publisher:

TUBITAK

Journal:

Turkish Journal of Medical Sciences 2010 Vol.40 Issue 5, pp.761-770

Document Type:

Article

Publication Date:

4/2010

Document Language:

Turkish

Document ID (Org No.):

2000754966

Frequency:

Bimonthly

eISSN:

1303-6165

pISSN:

1300-0144

Keywords:

Abstract:

 

We aimed to evaluate the comparative effects of levosimendan and dobutamine on P-wave dispersion (PWD) in the patients with acute decompensated heart failure (ADHF).  Materials and methods: The study population consisted of 40 patients (mean age = 68 years, 23 men, NYHA class III-IV) presented with ADHF. Patients were randomized to intravenous levosimendan (n = 20) or dobutamine (n = 20) groups. The P-wave duration measurements were calculated in 12-lead surface ECG simultaneously and recorded before and after treatment. Manual measurements of P-wave duration were performed with digital calipers on a high resolution computer screen by two cardiologists not aware of the patients' clinical data.   Results: There were no significant changes in P max in the dobutamine group whereas a significant decrease was observed in the levosimendan group after the infusion. The levosimendan infusion significantly reduced PWD (from 40 msec to 30 msec, P < 0.001) but the dobutamine infusion has no effect on PWD. In hospital new onset atrial fibrillation (AF) frequency was similar among two groups.   Conclusion: Levosimendan infusion significantly reduces PWD compared to dobutamine infusion in our study population. This finding may be related to hemodynamic improvements provided by levosimendan.

 

We aimed to evaluate the comparative effects of levosimendan and dobutamine on P-wave dispersion (PWD) in the patients with acute decompensated heart failure (ADHF).  Materials and methods: The study population consisted of 40 patients (mean age = 68 years, 23 men, NYHA class III-IV) presented with ADHF. Patients were randomized to intravenous levosimendan (n = 20) or dobutamine (n = 20) groups. The P-wave duration measurements were calculated in 12-lead surface ECG simultaneously and recorded before and after treatment. Manual measurements of P-wave duration were performed with digital calipers on a high resolution computer screen by two cardiologists not aware of the patients' clinical data.   Results: There were no significant changes in P max in the dobutamine group whereas a significant decrease was observed in the levosimendan group after the infusion. The levosimendan infusion significantly reduced PWD (from 40 msec to 30 msec, P < 0.001) but the dobutamine infusion has no effect on PWD. In hospital new onset atrial fibrillation (AF) frequency was similar among two groups.   Conclusion: Levosimendan infusion significantly reduces PWD compared to dobutamine infusion in our study population. This finding may be related to hemodynamic improvements provided by levosimendan.

Article Details

Comparative effects of levosimendan and dobutamine infusion on p wave dispersion in patients with acute decompensated heart failure

Authors:

Atila İYİSOY | Turgay ÇELİK | Murat ÇELİK | Barış BUĞAN | Halil YAMAN

Publisher:

TUBITAK

Journal:

Turkish Journal of Medical Sciences 2010 Vol.40 Issue 5, pp.761-770

Document Type:

Article

Publication Date:

4/2010

Document Language:

Turkish

Document ID (Org No.):

2000754966

Frequency:

Bimonthly

eISSN:

1303-6165

pISSN:

1300-0144

Key words: Acute decompensated heart failure

dobutamine

levosimendan

P-wave dispersion

Issues

Article Details

Comparative effects of levosimendan and dobutamine infusion on p wave dispersion in patients with acute decompensated heart failure

Authors: Atila İYİSOY | Turgay ÇELİK | Murat ÇELİK | Barış BUĞAN | Halil YAMAN

Publisher: TUBITAK

Journal: Turkish Journal of Medical Sciences 2010 Vol.40 Issue 5, pp.761-770

Document Type: Article

Publication Date: 4/2010

Document Language: Turkish

Document ID (Org No.): 2000754966

Frequency: Bimonthly

eISSN: 1303-6165

pISSN: 1300-0144

Key words: Acute decompensated heart failure

dobutamine

levosimendan

P-wave dispersion

Issues

Authors:

Atila İYİSOY | Turgay ÇELİK | Murat ÇELİK | Barış BUĞAN | Halil YAMAN

Publisher:

TUBITAK

Journal:

Turkish Journal of Medical Sciences 2010 Vol.40 Issue 5, pp.761-770

Document Type:

Article

Publication Date:

4/2010

Document Language:

Turkish

Document ID (Org No.):

2000754966

Frequency:

Bimonthly

eISSN:

1303-6165

pISSN:

1300-0144