Evaluation of Serum S100A8/S100A9 Levels in Patients with Autoimmune Thyroid Diseases

Hakan KORKMAZ; Suzan TABUR; Esen SAVAŞ; Mesut ÖZKAYA; Nurten AKSOY; Şefika  Nur AKSOY; Ersin AKARSU

Article Details

Evaluation of Serum S100A8/S100A9 Levels in Patients with Autoimmune Thyroid Diseases

Authors:

Hakan KORKMAZ | Suzan TABUR | Esen SAVAŞ | Mesut ÖZKAYA | Nurten AKSOY | Şefika Nur AKSOY | Ersin AKARSU

Publisher:

Trakya University

Journal:

Balkan Medical Journal 2016 Vol.33 Issue 5, pp.547-551

Document Type:

Article

Publication Date:

8/2016

Document Language:

Turkish

Document ID (Org No.):

2000759422

Frequency:

Bimonthly

pISSN:

2146-3123

Abstract:

 

Background: The correlation of S100A8/S100A9 with various inflammatory conditions, including autoimmune diseases have been reported. There is no study investigating the levels of S100A8/S100A9 in autoimmune thyroid diseases (AITD)     Aims: We aimed to evaluate the level of serum S100A8/S100A9 in AITD.     Study Design: Case control study.     Methods: Fifty patients with AITD (25 Hashimoto’s thyroiditis (HT) and 25 Graves’ disease (GD)) were included in the study. Twenty seven healthy subjects participated as a control group. Blood samples were obtained in the 3 months after the initiation of medical treatment. Serum levels of total antioxidant status (TAS), total oxidative status (TOS), total free sulfhydryl (SH), lipid hydroperoxide (LOOH) and S100A8/S100A9 were analyzed.     Results: The patients with AITD had significantly higher S100A8/S100A9, OSI, LOOH and TOS levels than the healthy control group. There was no significant difference between GD and HT patients in terms of S100A8/S100A9, TOS and OSI levels. S100A8/S100A9 level was positively correlated with LOOH, TOS and OSI levels but negatively correlated with –SH level in the patients with AITD.     Conclusion: Serum S100A8/S100A9 levels were increased in patients with AITD and positively correlated with LOOH, TOS and OSI whereas negatively correlated with SH.

Article Details

Evaluation of Serum S100A8/S100A9 Levels in Patients with Autoimmune Thyroid Diseases

Authors: Hakan KORKMAZ | Suzan TABUR | Esen SAVAŞ | Mesut ÖZKAYA | Nurten AKSOY | Şefika Nur AKSOY | Ersin AKARSU

Publisher: Trakya University

Journal: Balkan Medical Journal 2016 Vol.33 Issue 5, pp.547-551

Document Type: Article

Publication Date: 8/2016

Document Language: Turkish

Document ID (Org No.): 2000759422

Frequency: Bimonthly

pISSN: 2146-3123

Issues

Authors:

Hakan KORKMAZ | Suzan TABUR | Esen SAVAŞ | Mesut ÖZKAYA | Nurten AKSOY | Şefika Nur AKSOY | Ersin AKARSU

Publisher:

Trakya University

Journal:

Balkan Medical Journal 2016 Vol.33 Issue 5, pp.547-551

Document Type:

Article

Publication Date:

8/2016

Document Language:

Turkish

Document ID (Org No.):

2000759422

Frequency:

Bimonthly

pISSN:

2146-3123