A Consideration of Antibacterial Agent Efficacies in the Treatment and Prevention of Formation of Staphylococcus aureus Biofilm

Zahra SEDARAT; Andrew W. TAYLOR-ROBİNSON

doi:https://doi.org/10.5799/jmid.657903

Article Details

A Consideration of Antibacterial Agent Efficacies in the Treatment and Prevention of Formation of Staphylococcus aureus Biofilm

Authors:

Zahra SEDARAT | Andrew W. TAYLOR-ROBİNSON

Publisher:

Sağlık Araştırmaları Derneği

Main Topics:

Promotion of health

Journal:

Journal of Microbiology and Infectious Diseases 2019 Vol.09 Issue 04, pp.167-172

Document Type:

Article

Publication Date:

12/2019

Document Language:

English

Document ID (Org No.):

2000487294

Frequency:

Quarterly

eISSN:

2146-9369

pISSN:

2146-3158

DOI:

https://doi.org/10.5799/jmid.657903

Abstract:

 

Staphylococcus aureus is a Gram-positive bacterium found frequently on a person’s skin and sometimes in their upper respiratory tract. Although regarded primarily as a commensal of the human microbiota S. aureus shows the ability to become an opportunistic pathogen. Hence, it is a common cause of skin and lung infections and of food poisoning. S. aureus forms biofilms, complex communities of bacteria inside an exopolysaccharide matrix, which adhere to different surfaces, including those associated with hospital-acquired infections such as catheters, shunts and other implanted medical devices. In this instance, the presence of proteins adsorbed to the surface of the biomaterial provides a nutrient source for bacterial growth. 
Due to antimicrobial resistance, use of longstanding antibiotics alone is increasingly an ineffective therapeutic intervention for biofilm-related infections. Therefore, a growing concern is the treatment of medical devices in order to prevent antibiotic resistance associated with routine handling of these items in a healthcare setting. Consequently, several different biotechnological approaches have targeted a practical solution to S. aureus biofilm formation. These include novel antibiotics administered alone or combined with other compounds, application of natural products like enzymes and antimicrobial peptides, and harnessing of nanoparticles and phage therapy. This brief article provides an overview of each of these cutting-edge methods aimed at inhibition of S. aureus biofilms. Development of an effective agent to prevent and treat biofilm formation would represent a significant step forward for infection control of methicillin-resistant S. aureus (MRSA) and other antibiotic-resistant strains that provides a major global public health challenge. J Microbiol Infect Dis 2019; 9(4):167-172.

Article Details

A Consideration of Antibacterial Agent Efficacies in the Treatment and Prevention of Formation of Staphylococcus aureus Biofilm

Authors: Zahra SEDARAT | Andrew W. TAYLOR-ROBİNSON

Publisher: Sağlık Araştırmaları Derneği

Main Topics: Promotion of health

Journal: Journal of Microbiology and Infectious Diseases 2019 Vol.09 Issue 04, pp.167-172

Document Type: Article

Publication Date: 12/2019

Document Language: English

Document ID (Org No.): 2000487294

Frequency: Quarterly

eISSN: 2146-9369

pISSN: 2146-3158

DOI: https://doi.org/10.5799/jmid.657903

Issues

Authors:

Zahra SEDARAT | Andrew W. TAYLOR-ROBİNSON

Publisher:

Sağlık Araştırmaları Derneği

Main Topics:

Promotion of health

Journal:

Journal of Microbiology and Infectious Diseases 2019 Vol.09 Issue 04, pp.167-172

Document Type:

Article

Publication Date:

12/2019

Document Language:

English

Document ID (Org No.):

2000487294

Frequency:

Quarterly

eISSN:

2146-9369

pISSN:

2146-3158

DOI:

https://doi.org/10.5799/jmid.657903