Alterations in Vascular Functions in Experimental Androgen Deprivation = التغيرات الوظيفية للأوعية الدموية في حالة النقص التجريبي لهرمون الذكورة

Faten M. A. Diab; M. Hani Ayobe; Amira M. Abdel Rahman; Mona A. Ahmed; M. H. Elsayed; Ghida M. Hassan

doi:10.12816/0051512

Article Details

Alterations in Vascular Functions in Experimental Androgen Deprivation = التغيرات الوظيفية للأوعية الدموية في حالة النقص التجريبي لهرمون الذكورة

Authors:

Faten M. A. Diab | M. Hani Ayobe | Amira M. Abdel Rahman | Mona A. Ahmed | M. H. Elsayed | Ghida M. Hassan

Publisher:

Ain Shams Clinical and Scientific Society

Main Topics:

Medicine

Journal:

Ain Shams Medical Journal 2015 Vol.66 Issue 4-6, pp.273-288

Document Type:

Article

Publication Date:

6/2015

Document Language:

English

Document ID (Org No.):

129781

Frequency:

Quarterly

pISSN:

00022144

DOI:

10.12816/0051512

Descriptors:

Keywords:

Abstract:

 Background: The relationship between circulating testosterone and various aspects of cardiovascular health is not clearly understood. Some studies demonstrated that low testosterone levels are associated with development of cardiovascular diseases while others suggest that androgens are cardioprotective in males. 
Aim of the work: The present work was performed to investigate the mechanisms underlying vascular dysfunction and to shed light on the cardiovascular risk factors in androgen-deprived state. 
Materials and Methods: Adult male Wistar rats were exposed to androgen-deprived state whether through surgical orchidectomy or through finasteride treatment. Both groups were subjected to body weight measurement, recording of ECG, measurement of arterial blood pressure, measurement of plasma androgens, plasma catalase (CAT) enzyme activity and plasma malondialdhyde (MDA) levels. For the surgically orchidectomized rats (ORX), baroreflex functions, aortic vascular reactivity, and aortic nitrate level were determined. Estimation of plasma lipid profile as well as cardiac weights was done in the finasteride-treated rats. 
Results: Significant reduction in the plasma androgens was present in both groups with a significant increase in their final body weights. In the ORX rats, significant increase in the heart rate, QRS complex duration, aortic ring ACh/PE ratio, plasma malondialdhyde level existed. But significant decrease in the aortic ring responses to phenylephrine, plasma catalase activity and aortic tissue nitrate was evident. In the finasteride-treated rats, the QTo and QTc and high density lipoprotein-cholesterol (HDL-c) were significantly increased. Moreover, the plasma levels of triglycerides (TG), total cholesterol (TC), and low density lipoprotein-cholesterol (LDL-c) was significantly decreased. 
Conclusion: The hypogonadal state has a limited safety margin, and deterioration in cardiac and vascular functions in the absence of male sex hormones may occur, thereby suggesting protective effects of androgens on the cardiovascular system. Therefore, it could be assumed that, provided there is no contraindication such as cancer prostate, testosterone replacement therapy is to be considered for treatment of hypogonadal men especially those with risk factors for coronary vascular disease.

Article Details

Alterations in Vascular Functions in Experimental Androgen Deprivation = التغيرات الوظيفية للأوعية الدموية في حالة النقص التجريبي لهرمون الذكورة

Authors:

Faten M. A. Diab | M. Hani Ayobe | Amira M. Abdel Rahman | Mona A. Ahmed | M. H. Elsayed | Ghida M. Hassan

Publisher:

Ain Shams Clinical and Scientific Society

Main Topics:

Medicine

Journal:

Ain Shams Medical Journal 2015 Vol.66 Issue 4-6, pp.273-288

Document Type:

Article

Publication Date:

6/2015

Document Language:

English

Document ID (Org No.):

129781

Frequency:

Quarterly

pISSN:

00022144

DOI:

10.12816/0051512

Descriptors:

CARDIOVASCULAR DISEASES

ARTERIAL PRESSURE

SEX HORMONES

TESTES

LABORATORY ANIMALS

DIAGNOSIS

Androgen-Deprived State

Baroreceptor

Aortic Vascular Reactivity

Plasma Redox State

Lipid Profile

Issues

Article Details

Authors: Faten M. A. Diab | M. Hani Ayobe | Amira M. Abdel Rahman | Mona A. Ahmed | M. H. Elsayed | Ghida M. Hassan

Publisher: Ain Shams Clinical and Scientific Society

Main Topics: Medicine

Journal: Ain Shams Medical Journal 2015 Vol.66 Issue 4-6, pp.273-288

Document Type: Article

Publication Date: 6/2015

Document Language: English

Document ID (Org No.): 129781

Frequency: Quarterly

pISSN: 00022144

DOI: 10.12816/0051512

Descriptors:

Issues

Authors:

Faten M. A. Diab | M. Hani Ayobe | Amira M. Abdel Rahman | Mona A. Ahmed | M. H. Elsayed | Ghida M. Hassan

Publisher:

Ain Shams Clinical and Scientific Society

Main Topics:

Medicine

Journal:

Ain Shams Medical Journal 2015 Vol.66 Issue 4-6, pp.273-288

Document Type:

Article

Publication Date:

6/2015

Document Language:

English

Document ID (Org No.):

129781

Frequency:

Quarterly

pISSN:

00022144

DOI:

10.12816/0051512