Effect of isoflavone on plasma nitrite/nitrate, homocysteine, and lipid levels in Turkish women in the early postmenopausal period: a randomized controlled trial

Nilgün ÖZTÜRK TURHAN

Article Details

Effect of isoflavone on plasma nitrite/nitrate, homocysteine, and lipid levels in Turkish women in the early postmenopausal period: a randomized controlled trial

Authors:

Nilgün ÖZTÜRK TURHAN

Publisher:

TUBITAK

Main Topics:

Promotion of health

Journal:

Turkish Journal of Medical Sciences 2009 Vol.39 Issue 3, pp.367-375

Document Type:

Article

Publication Date:

2/2009

Document Language:

English

Document ID (Org No.):

2000755432

Frequency:

Bimonthly

eISSN:

1303-6165

pISSN:

1300-0144

Keywords:

Abstract:

 

Aim: The aim of the study was to evaluate the effect of isoflavones on cardiovascular risk markers including plasma nitrite/nitrate, homocysteine, and lipid levels in Turkish women in the early postmenopausal period.   Materials and Methods: Ninety participants between 42 and 59 years of age were randomly assigned to receive twice a day either isoflavone tablet (n:45) or placebo tablets (n = 45). Plasma nitrite/nitrate, homocysteine, and lipid levels were measured at baseline and after the 6 months of treatment.   Results: After 6 months, isoflavone resulted in a statistically significant decrease in total cholesterol, low-density lipoproteins, triglyceride levels, serum homocysteine and an increase in high-density lipoproteins and serum nitrites/nitrates. Lipoprotein-a level did not change in both groups.   Conclusions: Six months of treatment with isoflavones had a favorable effect on serum nitrites/nitrates, homocysteine and lipid levels in Turkish women in the early postmenopausal period. Although there is not enough evidence yet from large randomized clinical trials to make a recommendation about the use of phytoestrogens for prevention of cardiovascular disease in postmenopausal years, our results show that phytoestrogens improve the biomarkers of some cardiovascular risk markers in Turkish women in the early postmenopausal period.

 

Amaç: Bu çalışmanın amacı erken postmenapozal dönemdeki Türk kadınlarında isoflavonlarınplazma nitrit/nitrat, homosistein ve lipit düzeyleri gibi kardiovasküler risk faktörleri üzerine olanetkilerini değerlendirmektir.Yöntem ve Gereç: Yaşları 42-59 arasında değişen 90 katılımcı günde 2 kez isoflavon veya plasebotablet alacak şekilde rastgele olarak belirlendi. Plazma nitrit/nitrat, homosistein ve lipit düzeyleribaşlangıçta ve tedavinin 6. ayında ölçüldü.Bulgular: Altı ay sonra isoflavon, total kolesterol, LDL, serum homosistein ve trigliseritdüzeylerinde istatistiksel olarak belirgin bir düşme, HDL ve serum nitrit/nitratlarında ise yükselmesağladı. Lp(a) düzeylerinde her iki grupta da bir değişiklik görülmedi.Sonuç: Altı aylık bir isoflavon tedavisinin erken dönem postmenapozal Türk kadınlarında serumnitrit/nitrat, homosistein ve lipit düzeyleri üzerine olumlu bir etkisi oldu. Postmenapozal dönemdekardiovasküler hastalıklardan korunmak amacıyla fitoöstrojenlerin kullanılmasının tavsiyeedilebilmesi için henüz geniş ve randomize çalışmalarca desteklenen yeterli kanıtlar olmamasınarağmen bizim sonuçlarımız erken dönem postmenapozal Türk kadınlarında fitoöstrojenlerin bazıkardiovasküler risk parametrelerinde gelişmelerde bulunduğunu göstermiştir.

Article Details

Effect of isoflavone on plasma nitrite/nitrate, homocysteine, and lipid levels in Turkish women in the early postmenopausal period: a randomized controlled trial

Authors:

Nilgün ÖZTÜRK TURHAN

Publisher:

TUBITAK

Main Topics:

Promotion of health

Journal:

Turkish Journal of Medical Sciences 2009 Vol.39 Issue 3, pp.367-375

Document Type:

Article

Publication Date:

2/2009

Document Language:

English

Document ID (Org No.):

2000755432

Frequency:

Bimonthly

eISSN:

1303-6165

pISSN:

1300-0144

Menopoz

isoflavon

nitrit/nitrat

homosistein

lipit

Issues

Article Details

Effect of isoflavone on plasma nitrite/nitrate, homocysteine, and lipid levels in Turkish women in the early postmenopausal period: a randomized controlled trial

Authors: Nilgün ÖZTÜRK TURHAN

Publisher: TUBITAK

Main Topics: Promotion of health

Journal: Turkish Journal of Medical Sciences 2009 Vol.39 Issue 3, pp.367-375

Document Type: Article

Publication Date: 2/2009

Document Language: English

Document ID (Org No.): 2000755432

Frequency: Bimonthly

eISSN: 1303-6165

pISSN: 1300-0144

Menopoz

isoflavon

nitrit/nitrat

homosistein

lipit

Issues

Authors:

Nilgün ÖZTÜRK TURHAN

Publisher:

TUBITAK

Main Topics:

Promotion of health

Journal:

Turkish Journal of Medical Sciences 2009 Vol.39 Issue 3, pp.367-375

Document Type:

Article

Publication Date:

2/2009

Document Language:

English

Document ID (Org No.):

2000755432

Frequency:

Bimonthly

eISSN:

1303-6165

pISSN:

1300-0144