Synthesis, anticandidal activity, and cytotoxicity of some thiazole derivatives with dithiocarbamate side chains

Leyla YURTTAŞ; Yusuf ÖZKAY; Fatih DEMİRCİ; Gamze GÖGER; Şafak Ulusoylar YILDIRIM; Usama ABU MOHSEN; Ömer ÖZTÜRK; Zafer Asım KAPLANCIKLI

doi:https://doi.org/10.3906/kim-1312-62

Article Details

Synthesis, anticandidal activity, and cytotoxicity of some thiazole derivatives with dithiocarbamate side chains

Authors:

Leyla YURTTAŞ | Yusuf ÖZKAY | Fatih DEMİRCİ | Gamze GÖGER | Şafak Ulusoylar YILDIRIM | Usama ABU MOHSEN | Ömer ÖZTÜRK | Zafer Asım KAPLANCIKLI

Publisher:

TUBITAK

Main Topics:

Applied physics

Journal:

Turkish Journal of Chemistry 2014 Vol.38 Issue 5, pp.815-824

Document Type:

Article

Publication Date:

4/2014

Document Language:

English

Document ID (Org No.):

2000727085

Frequency:

Bimonthly

eISSN:

1303-6130

pISSN:

1300-0527

DOI:

https://doi.org/10.3906/kim-1312-62

Abstract:

 

Some thiazole derivatives bearing dithiocarbamic acid esters were  synthesized in order to investigate their anticandidal activity and  cytotoxicity. The structures of the obtained final compounds  (6a--j) were confirmed by spectral data (IR, 1H NMR,  13C NMR, and MS) and elemental analysis. The anticandidal activity of  the compounds was determined (6a--j) using the microbroth  dilution method and their cytotoxicity was evaluated according to the MTT  (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay against  normal cells. Contrary to expectations, weak antifungal activity was  observed with IC50 values ranging between 30 and 403 m g/mL.

 

Some thiazole derivatives bearing dithiocarbamic acid esters were  synthesized in order to investigate their anticandidal activity and  cytotoxicity. The structures of the obtained final compounds  (6a--j) were confirmed by spectral data (IR, 1H NMR,  13C NMR, and MS) and elemental analysis. The anticandidal activity of  the compounds was determined (6a--j) using the microbroth  dilution method and their cytotoxicity was evaluated according to the MTT  (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay against  normal cells. Contrary to expectations, weak antifungal activity was  observed with IC50 values ranging between 30 and 403 m g/mL.

Article Details

Synthesis, anticandidal activity, and cytotoxicity of some thiazole derivatives with dithiocarbamate side chains

Authors: Leyla YURTTAŞ | Yusuf ÖZKAY | Fatih DEMİRCİ | Gamze GÖGER | Şafak Ulusoylar YILDIRIM | Usama ABU MOHSEN | Ömer ÖZTÜRK | Zafer Asım KAPLANCIKLI

Publisher: TUBITAK

Main Topics: Applied physics

Journal: Turkish Journal of Chemistry 2014 Vol.38 Issue 5, pp.815-824

Document Type: Article

Publication Date: 4/2014

Document Language: English

Document ID (Org No.): 2000727085

Frequency: Bimonthly

eISSN: 1303-6130

pISSN: 1300-0527

DOI: https://doi.org/10.3906/kim-1312-62

Issues

Authors:

Leyla YURTTAŞ | Yusuf ÖZKAY | Fatih DEMİRCİ | Gamze GÖGER | Şafak Ulusoylar YILDIRIM | Usama ABU MOHSEN | Ömer ÖZTÜRK | Zafer Asım KAPLANCIKLI

Publisher:

TUBITAK

Main Topics:

Applied physics

Journal:

Turkish Journal of Chemistry 2014 Vol.38 Issue 5, pp.815-824

Document Type:

Article

Publication Date:

4/2014

Document Language:

English

Document ID (Org No.):

2000727085

Frequency:

Bimonthly

eISSN:

1303-6130

pISSN:

1300-0527

DOI:

https://doi.org/10.3906/kim-1312-62