Comparison of the efficacy of oral and parenteral bisphosphonates in patients with postmenopausal osteoporosis: A single-center, retrospective clinical study

Serdar MENEKŞE; Dursune MENEKŞE

doi:https://doi.org/10.18663/tjcl.764506

Article Details

Comparison of the efficacy of oral and parenteral bisphosphonates in patients with postmenopausal osteoporosis: A single-center, retrospective clinical study

Authors:

Serdar MENEKŞE | Dursune MENEKŞE

Publisher:

DNT Ortadoğu Yayıncılık A.Ş.

Main Topics:

Promotion of health

Journal:

Turkish Journal of Clinics and Laboratory 2022 Vol.13 Issue 1, pp.146-152

Document Type:

Article

Publication Date:

3/2022

Document Language:

English

Document ID (Org No.):

2000631490

Frequency:

Quarterly

eISSN:

2149-8296

DOI:

https://doi.org/10.18663/tjcl.764506

Abstract:

 

Aim: The aim of the study is to compare the efficacy of oral and parenteral bisphosphonates used in the treatment of postmenopausal osteoporosis.
Material and Methods: Patients older than 50 years who were diagnosed with postmenopausal OP and treated with oral or parenteral bisphosphonate between 2016 and 2019 were included in the study. The patients were grouped by treatment; 80 patients receiving oral bisphosphonate and 80 patients receiving parenteral bisphosphonate were divided into two groups as group ‘O’ and group ‘P’, respectively. The results of the second-year treatment of 160 patients, who were treated regularly and could be followed-up for at least 2 years, were evaluated and compared.  Results: According to the pre-treatment state in both groups; vertebral and femoral bone mineral density (BMD) and T-scores showed significant improvement. The mean improvement in vertebral and femoral T-scores and femoral BMD values was better in group ‘P’ with a statistically significant difference. In the oral bisphosphonate group, there was a statistically significant difference between the groups in favor of alendronate in the femoral T-score, while, in the parenteral bisphosphonate group, the improvement in the vertebral and femoral T-score was better in the zoledronate subgroup and statistically significant.
Conclusion: This study concluded that oral and parenteral bisphosphonates are effective in the treatment of postmenopausal OP. Nevertheless, parenteral bisphosphonates were found to be more effective in terms of mean improvement in vertebral and femoral T-scores and femoral BMD.

 

Amaç: Çalışmamız postmenopozal osteoporoz (OP) tedavisinde kullanılan oral ve parenteral bifosfanatların etkinliklerini karşılaştırmayı amaçlamaktadır.
Gereç ve Yöntemler: 2016-2019 yılları arasında postmenopozal OP tanısı konularak, oral ya da parenteral bifosfonat ile tedavi edilen 50 yaş üstü hastalar çalışmaya dahil edildi. Tedaviye göre oral bifosfonat alan 80 hasta grup ‘O’ ve parenteral bifosfonat alan 80 hasta grup ‘P’ olarak iki gruba ayrıldı. Tedavilerini düzenli alan ve en az 2 yıl takibi yapılabilen 160 hastanın tedavinin 2. yıldaki sonuçları değerlendirilerek karşılaştırıldı. Bulgular: Her iki grupta tedavi öncesine göre; vertebra ve femur kemik mineral yoğunluğu (BMD) ve T-skorlarında anlamlı düzelme olduğu görüldü. Vertebra ve femur T-skorundaki ve femur BMD değerindeki ortalama düzelme bakımından grup ‘P’ daha iyiydi ve istatistiksel olarak anlamlı fark vardı. Oral bifosfonat grubunda femur T-skorunda alendronat lehine gruplar arasında istatistiksel anlamlı fark olduğu ve parenteral bifosfonat grubunda ise vertebra ve femur T-skorundaki düzelme zoledronat alt grubunda daha iyiydi ve istatistiksel olarak anlamlıydı.
Sonuç: Çalışmamızın sonuçları; postmenopozal OP’nin tedavisinde oral ve parenteral bifosfonatların etkili olduğunu göstermektedir. Bununla birlikte vertebra ve femur T-skorlarında ve femur KMY ortalama düzelme bakımından parenteral bifosfonatlar daha etkili bulundu.

Article Details

Comparison of the efficacy of oral and parenteral bisphosphonates in patients with postmenopausal osteoporosis: A single-center, retrospective clinical study

Authors: Serdar MENEKŞE | Dursune MENEKŞE

Publisher: DNT Ortadoğu Yayıncılık A.Ş.

Main Topics: Promotion of health

Journal: Turkish Journal of Clinics and Laboratory 2022 Vol.13 Issue 1, pp.146-152

Document Type: Article

Publication Date: 3/2022

Document Language: English

Document ID (Org No.): 2000631490

Frequency: Quarterly

eISSN: 2149-8296

DOI: https://doi.org/10.18663/tjcl.764506

Issues

Authors:

Serdar MENEKŞE | Dursune MENEKŞE

Publisher:

DNT Ortadoğu Yayıncılık A.Ş.

Main Topics:

Promotion of health

Journal:

Turkish Journal of Clinics and Laboratory 2022 Vol.13 Issue 1, pp.146-152

Document Type:

Article

Publication Date:

3/2022

Document Language:

English

Document ID (Org No.):

2000631490

Frequency:

Quarterly

eISSN:

2149-8296

DOI:

https://doi.org/10.18663/tjcl.764506