Prognostic Value of Interleukin-17 a Gene Polymorphism and Serum IL-17 Levels in Adult Acute Myeloid Leukaemia Patients

Alnagar , Ahmed A.; Mourad , Mohamed H.; Farrag , Zainab A.; Kamel , Lamiaa M.

Article Details

Prognostic Value of Interleukin-17 a Gene Polymorphism and Serum IL-17 Levels in Adult Acute Myeloid Leukaemia Patients

Authors:

Alnagar , Ahmed A. | Mourad , Mohamed H. | Farrag , Zainab A. | Kamel , Lamiaa M.

Publisher:

Pan Arab League of Continuous Medical Education

Main Topics:

Medicine

Journal:

The Egyptian Journal of Hospital Medicine 2020 Vol.81 Issue 2, pp.1352-1358

Document Type:

Article

Publication Date:

10/2020

Document Language:

English

Document ID (Org No.):

142441

Frequency:

Quarterly

eISSN:

20907125

pISSN:

16872002

Descriptors:

Keywords:

Abstract:

 Background: T helper 17 (Th17) cells play a role in the pathogenesis and prognosis of acute myeloid leukemia (AML). Th17 cells produce interleukin (IL)-17A and IL-17F, that share strong surface expression and homology of the IL-23 receptor (IL-23R). Objective: To evaluate the expression of IL-17A gene polymorphism and IL-17 serum level in adult AML patients and to clarify its prognostic significance. Patients and methods: In this prospective study, 48 patients with de novo AML and 48 healthy matched controls were enrolled. Cases were diagnosed at clinical pathology and managed in Medical Oncology Departments. We evaluated both serum IL-17 levels, measured by ELISA, and IL-17A (rs2275913) gene polymorphism was assessed using real-time polymerase chain reaction (PCR) in all patients and control. All patients received “3+7” as induction, responders received 3-4 courses of high dose cytarabine as consolidation, while non-responders received salvage therapy. Results: Serum levels of IL-17 were higher in AML patients (median 27 pg/ml) vs 17 pg/ml in the control group (P < 0.001). Also, serum IL 17 level was higher in non-responders with median 37.5 (pg/ml) vs 23 (pg/ml) in responders (P < 0.001). while IL-17A mutant genotypes and alleles showed no significant relation between expression of IL-17 A gene polymorphism and response to treatment or outcome of studied AML cases. Conclusion: Serum IL-17 levels can be considered a useful diagnostic and prognostic factor in AML patients, unlike IL-17 A gene polymorphisms.

Article Details

Prognostic Value of Interleukin-17 a Gene Polymorphism and Serum IL-17 Levels in Adult Acute Myeloid Leukaemia Patients

Authors:

Alnagar , Ahmed A. | Mourad , Mohamed H. | Farrag , Zainab A. | Kamel , Lamiaa M.

Publisher:

Pan Arab League of Continuous Medical Education

Main Topics:

Medicine

Journal:

The Egyptian Journal of Hospital Medicine 2020 Vol.81 Issue 2, pp.1352-1358

Document Type:

Article

Publication Date:

10/2020

Document Language:

English

Document ID (Org No.):

142441

Frequency:

Quarterly

eISSN:

20907125

pISSN:

16872002

Descriptors:

MYELOID LEUKEMIA

LEUKEMIA

INTERLEUKINS

GENETIC POLYMORPHISM

SERA

PATIENTS

ADULTS

EGYPT

IL-17

Prognostic

Polymorphisms

AML

Issues

Article Details

Authors: Alnagar , Ahmed A. | Mourad , Mohamed H. | Farrag , Zainab A. | Kamel , Lamiaa M.

Publisher: Pan Arab League of Continuous Medical Education

Main Topics: Medicine

Journal: The Egyptian Journal of Hospital Medicine 2020 Vol.81 Issue 2, pp.1352-1358

Document Type: Article

Publication Date: 10/2020

Document Language: English

Document ID (Org No.): 142441

Frequency: Quarterly

eISSN: 20907125

pISSN: 16872002

Descriptors:

Issues

Authors:

Alnagar , Ahmed A. | Mourad , Mohamed H. | Farrag , Zainab A. | Kamel , Lamiaa M.

Publisher:

Pan Arab League of Continuous Medical Education

Main Topics:

Medicine

Journal:

The Egyptian Journal of Hospital Medicine 2020 Vol.81 Issue 2, pp.1352-1358

Document Type:

Article

Publication Date:

10/2020

Document Language:

English

Document ID (Org No.):

142441

Frequency:

Quarterly

eISSN:

20907125

pISSN:

16872002