Hydroxyurea : Pattern of Use, Patient Adherence, and Safety Profile in Patients with Sickle Cell Disease in Oman

Jose , Jimmy; Elsadek , Refaat Abdullah; Jimmy , Beena; George , Prasad

doi:10.5001/omj.2019.64

Article Details

Hydroxyurea : Pattern of Use, Patient Adherence, and Safety Profile in Patients with Sickle Cell Disease in Oman

Authors:

Jose , Jimmy | Elsadek , Refaat Abdullah | Jimmy , Beena | George , Prasad

Publisher:

Oman Medical Specialty Board

Main Topics:

Medicine

Journal:

Oman Medical Journal 2019 Vol.34 Issue 4, pp.327-335

Document Type:

Article

Publication Date:

7/2019

Document Language:

English

Document ID (Org No.):

230239

Frequency:

Bi-Monthly

eISSN:

20705204

pISSN:

1999768X

DOI:

10.5001/omj.2019.64

Descriptors:

Keywords:

Abstract:

 Objectives: Many barriers contribute to the underutilization of hydroxyurea (HU) in thetreatment of sickle cell disease (SCD), and adherence to its use is often reported to besuboptimal. It is important to have information on the safety of HU in patients with SCD.Our study assessed the pattern of use, patients’ adherence to medication, discontinuationof use, and safety of HU in patients with SCD. Methods: This cross-sectional study wasconducted in the department of medicine of a referral hospital in Oman over five monthsand included a review of patient files and patient interview. Approval was obtained fromthe Regional Research and Ethics Committee of the A'Dakhiliyah Governorate andthe hospital administration. The parameters were compared between groups using thechi-square test. Results: Of 298 patients studied, 128 (43.0%) had used HU at somepoints. The difference in the prevalence of HU use was statistically significant based onlyon age (p = 0.014), with younger patients more likely to be currently using HU or usedHU in the past. The majority of patients were adherent (82.5%) based on self-reportedadherence. The prevalence of discontinuation (temporary or permanent) of HU use washigh (57.0%), and suspected adverse drug reaction (ADR) was the most common reason.Among those who had never used HU, 33.7% of patients had an indication for theinitiation of HU. A quarter of patients who used HU developed a suspected ADR, withblood abnormalities being the commonest. The duration of HU use influenced ADRprevalence (p = 0.015). Conclusions: Among the current users of HU, the majority of thepatients were adherent based on self-reported medication adherence. The prevalence ofdiscontinuation of HU use and instances of non-initiation of HU among those indicatedwere high. A larger study, ideally of a prospective nature, in various governorates of Oman,would provide a wider picture at the national level.

Article Details

Hydroxyurea : Pattern of Use, Patient Adherence, and Safety Profile in Patients with Sickle Cell Disease in Oman

Authors:

Jose , Jimmy | Elsadek , Refaat Abdullah | Jimmy , Beena | George , Prasad

Publisher:

Oman Medical Specialty Board

Main Topics:

Medicine

Journal:

Oman Medical Journal 2019 Vol.34 Issue 4, pp.327-335

Document Type:

Article

Publication Date:

7/2019

Document Language:

English

Document ID (Org No.):

230239

Frequency:

Bi-Monthly

eISSN:

20705204

pISSN:

1999768X

DOI:

10.5001/omj.2019.64

Descriptors:

ANAEMIA

BLOOD DISEASES

PATIENTS

OMAN

Sickle Cell Disease

Hydroxyurea

Oman

Medication Adherence

Safety

Issues

Article Details

Authors: Jose , Jimmy | Elsadek , Refaat Abdullah | Jimmy , Beena | George , Prasad

Publisher: Oman Medical Specialty Board

Main Topics: Medicine

Journal: Oman Medical Journal 2019 Vol.34 Issue 4, pp.327-335

Document Type: Article

Publication Date: 7/2019

Document Language: English

Document ID (Org No.): 230239

Frequency: Bi-Monthly

eISSN: 20705204

pISSN: 1999768X

DOI: 10.5001/omj.2019.64

Descriptors:

Issues

Authors:

Jose , Jimmy | Elsadek , Refaat Abdullah | Jimmy , Beena | George , Prasad

Publisher:

Oman Medical Specialty Board

Main Topics:

Medicine

Journal:

Oman Medical Journal 2019 Vol.34 Issue 4, pp.327-335

Document Type:

Article

Publication Date:

7/2019

Document Language:

English

Document ID (Org No.):

230239

Frequency:

Bi-Monthly

eISSN:

20705204

pISSN:

1999768X

DOI:

10.5001/omj.2019.64