Cushing’s Syndrome : An Epidemiological Study Based on a Canine Population of 21, 281 Dogs

Carotenuto , Gaia; Malerba , Eleonora; Dolfini , Costanza; Brugnoli , Francesca; Giannuzzi , Pasquale; Semprini , Giovanni; Tosolini , Paolo; Fracassi , Federico

doi:10.4314/ovj.v9i1.5

Article Details

Cushing’s Syndrome : An Epidemiological Study Based on a Canine Population of 21, 281 Dogs

Authors:

Carotenuto , Gaia | Malerba , Eleonora | Dolfini , Costanza | Brugnoli , Francesca | Giannuzzi , Pasquale | Semprini , Giovanni | Tosolini , Paolo | Fracassi , Federico

Publisher:

Faculty of Veterinary Medicine, University of Tripoli

Main Topics:

Medicine | Zoological sciences/Animals

Journal:

Open Veterinary Journal 2019 Vol.9 Issue 1, pp.27-32

Document Type:

Article

Publication Date:

3/2019

Document Language:

English

Document ID (Org No.):

245832

Frequency:

Tri-Annual

eISSN:

22186050

pISSN:

22264485

DOI:

10.4314/ovj.v9i1.5

Descriptors:

Keywords:

Abstract:

 The epidemiological characteristics of spontaneous hypercortisolism (HC) were derived from 21,281 client-owned dogs selected from four private veterinary clinics and one university reference center for endocrinology. The odds ratio (OR) method was employed to investigate the risk of developing HC related to breed, gender, and sexual status. The estimated prevalence of HC in the four private clinics was 0.20% [95% confidence interval (CI), 0.13–0.27] and was significantly different compared to the university reference center (1.46%; 95% CI, 1.12–1.80). Sex, breed, and age resulted in risk factors for HC. Mean (± SD) age for dogs with HC was 9.8 (± 2.5) yr. Females had higher risk for HC compared to males (OR 1.85; 95% CI, 1.24–2.75); all neutered dogs (both males and females) had higher risk than intact dogs (OR 2.54; 95% CI, 1.72–3.73); and neutered females had higher risk compared to intact females (OR 2.61; 95% CI, 1.54–4.42). Using the mixed breed dogs as a control population (OR = 1), the risk of developing HC was significantly higher in the Standard Schnauzer (OR 58.1; p < 0.0001) and Fox Terrier (OR 20.33; p < 0.0001). With regard to HC, this study identified an overall prevalence of 0.20%. The data support the existence of sex predisposition, with the highest risk for neutered females.

Article Details

Cushing’s Syndrome : An Epidemiological Study Based on a Canine Population of 21, 281 Dogs

Authors:

Carotenuto , Gaia | Malerba , Eleonora | Dolfini , Costanza | Brugnoli , Francesca | Giannuzzi , Pasquale | Semprini , Giovanni | Tosolini , Paolo | Fracassi , Federico

Publisher:

Faculty of Veterinary Medicine, University of Tripoli

Main Topics:

Medicine | Zoological sciences/Animals

Journal:

Open Veterinary Journal 2019 Vol.9 Issue 1, pp.27-32

Document Type:

Article

Publication Date:

3/2019

Document Language:

English

Document ID (Org No.):

245832

Frequency:

Tri-Annual

eISSN:

22186050

pISSN:

22264485

DOI:

10.4314/ovj.v9i1.5

Descriptors:

VETERINARY MEDICINE

CUSHING'S SYNDROME

ENDOCRINE DISEASES

ANIMAL DISEASES

DOGS

Cortisol

Hyperadrenocorticism

Hypercortisolism

PDH

Issues

Article Details

Authors: Carotenuto , Gaia | Malerba , Eleonora | Dolfini , Costanza | Brugnoli , Francesca | Giannuzzi , Pasquale | Semprini , Giovanni | Tosolini , Paolo | Fracassi , Federico

Publisher: Faculty of Veterinary Medicine, University of Tripoli

Main Topics: Medicine | Zoological sciences/Animals

Journal: Open Veterinary Journal 2019 Vol.9 Issue 1, pp.27-32

Document Type: Article

Publication Date: 3/2019

Document Language: English

Document ID (Org No.): 245832

Frequency: Tri-Annual

eISSN: 22186050

pISSN: 22264485

DOI: 10.4314/ovj.v9i1.5

Descriptors:

Issues

Authors:

Carotenuto , Gaia | Malerba , Eleonora | Dolfini , Costanza | Brugnoli , Francesca | Giannuzzi , Pasquale | Semprini , Giovanni | Tosolini , Paolo | Fracassi , Federico

Publisher:

Faculty of Veterinary Medicine, University of Tripoli

Main Topics:

Medicine | Zoological sciences/Animals

Journal:

Open Veterinary Journal 2019 Vol.9 Issue 1, pp.27-32

Document Type:

Article

Publication Date:

3/2019

Document Language:

English

Document ID (Org No.):

245832

Frequency:

Tri-Annual

eISSN:

22186050

pISSN:

22264485

DOI:

10.4314/ovj.v9i1.5