Prognostic significance of prognostic nutritional index and hemoglobin to red cell distribution width ratio in metastatic colorectal cancer patients

Ender Doğan; Sedat Tarık Fırat; Murat Eser; Oktay Bozkurt; Mevlüde İnanç

Article Details

Prognostic significance of prognostic nutritional index and hemoglobin to red cell distribution width ratio in metastatic colorectal cancer patients

Authors:

Ender Doğan | Sedat Tarık Fırat | Murat Eser | Oktay Bozkurt | Mevlüde İnanç

Publisher:

MediHealth Academy Yayıncılık

Main Topics:

Klinik Onkoloji

Journal:

Anatolian Current Medical Journal Vol.5 Issue 4, pp.449-453

Document Type:

Article

Publication Date:

10/2023

Document Language:

English

Document ID (Org No.):

2001302556

pISSN:

2718-0115

Keywords:

Abstract:

 Aims: Malnutrition and systemic inflammation are poor prognostic factors in cancer. Prognostic nutritional index PNI and Hemoglobin to red blood cell distribution witdh HRR are considered indicators of malnutrition and systemic inflammation. We aimed to investigate the prognostic importance of PNI and HRR on metastatic colorectal cancer survival. Methods: We retrospectively reviewed all patients diagnosed with metastatic colorectal cancer treated at Kayseri City Training and Research Hospital and Erciyes University Medical School. PNI is calculated as serum albumin gL 5 x total lymphocyte count 10⁹L. And HRR was calculated as the ratio of hemoglobin gdl and RDW . PNI was divided into two groups based on the cut off points 46.175 as PNI high and low. And we compared these two groups according to general characteristics and overall survival. We performed another comparision between HRR low and high groups based on the cut off points 0.8675 according to general characteristics and overall survival. Kaplan Meier method was used to analyse overall survival and compared survival rates with the log-rank test. Results: We reviewed 346 metastatic colorectal cancer patients and we included 145 of them who fit to inclusion criteria to the study. Univariate analysis revealed that presence of initially metastatic disease, right located tumor, low HRR, low PNI were independent prognostic markers of poor overall survival. In multivariate analysis, presence of initially metastatic disease and low PNI remain statistically significant independent prognostic markers of poor survival. The median overall survival was statistically longer in HRR and PNI low groups than high groups. Conclusion: Both PNI and HRR are associated with poor overall survival in metastatic colorectal cancer.

 Aims: Malnutrition and systemic inflammation are poor prognostic factors in cancer. Prognostic nutritional index PNI and Hemoglobin to red blood cell distribution witdh HRR are considered indicators of malnutrition and systemic inflammation. We aimed to investigate the prognostic importance of PNI and HRR on metastatic colorectal cancer survival. Methods: We retrospectively reviewed all patients diagnosed with metastatic colorectal cancer treated at Kayseri City Training and Research Hospital and Erciyes University Medical School. PNI is calculated as serum albumin gL 5 x total lymphocyte count 10⁹L. And HRR was calculated as the ratio of hemoglobin gdl and RDW . PNI was divided into two groups based on the cut off points 46.175 as PNI high and low. And we compared these two groups according to general characteristics and overall survival. We performed another comparision between HRR low and high groups based on the cut off points 0.8675 according to general characteristics and overall survival. Kaplan Meier method was used to analyse overall survival and compared survival rates with the log-rank test. Results: We reviewed 346 metastatic colorectal cancer patients and we included 145 of them who fit to inclusion criteria to the study. Univariate analysis revealed that presence of initially metastatic disease, right located tumor, low HRR, low PNI were independent prognostic markers of poor overall survival. In multivariate analysis, presence of initially metastatic disease and low PNI remain statistically significant independent prognostic markers of poor survival. The median overall survival was statistically longer in HRR and PNI low groups than high groups. Conclusion: Both PNI and HRR are associated with poor overall survival in metastatic colorectal cancer.

 Aims: Malnutrition and systemic inflammation are poor prognostic factors in cancer. Prognostic nutritional index PNI and Hemoglobin to red blood cell distribution witdh HRR are considered indicators of malnutrition and systemic inflammation. We aimed to investigate the prognostic importance of PNI and HRR on metastatic colorectal cancer survival. Methods: We retrospectively reviewed all patients diagnosed with metastatic colorectal cancer treated at Kayseri City Training and Research Hospital and Erciyes University Medical School. PNI is calculated as serum albumin gL 5 x total lymphocyte count 10⁹L. And HRR was calculated as the ratio of hemoglobin gdl and RDW . PNI was divided into two groups based on the cut off points 46.175 as PNI high and low. And we compared these two groups according to general characteristics and overall survival. We performed another comparision between HRR low and high groups based on the cut off points 0.8675 according to general characteristics and overall survival. Kaplan Meier method was used to analyse overall survival and compared survival rates with the log-rank test. Results: We reviewed 346 metastatic colorectal cancer patients and we included 145 of them who fit to inclusion criteria to the study. Univariate analysis revealed that presence of initially metastatic disease, right located tumor, low HRR, low PNI were independent prognostic markers of poor overall survival. In multivariate analysis, presence of initially metastatic disease and low PNI remain statistically significant independent prognostic markers of poor survival. The median overall survival was statistically longer in HRR and PNI low groups than high groups. Conclusion: Both PNI and HRR are associated with poor overall survival in metastatic colorectal cancer.

 Aims: Malnutrition and systemic inflammation are poor prognostic factors in cancer. Prognostic nutritional index PNI and Hemoglobin to red blood cell distribution witdh HRR are considered indicators of malnutrition and systemic inflammation. We aimed to investigate the prognostic importance of PNI and HRR on metastatic colorectal cancer survival. Methods: We retrospectively reviewed all patients diagnosed with metastatic colorectal cancer treated at Kayseri City Training and Research Hospital and Erciyes University Medical School. PNI is calculated as serum albumin gL 5 x total lymphocyte count 10⁹L. And HRR was calculated as the ratio of hemoglobin gdl and RDW . PNI was divided into two groups based on the cut off points 46.175 as PNI high and low. And we compared these two groups according to general characteristics and overall survival. We performed another comparision between HRR low and high groups based on the cut off points 0.8675 according to general characteristics and overall survival. Kaplan Meier method was used to analyse overall survival and compared survival rates with the log-rank test. Results: We reviewed 346 metastatic colorectal cancer patients and we included 145 of them who fit to inclusion criteria to the study. Univariate analysis revealed that presence of initially metastatic disease, right located tumor, low HRR, low PNI were independent prognostic markers of poor overall survival. In multivariate analysis, presence of initially metastatic disease and low PNI remain statistically significant independent prognostic markers of poor survival. The median overall survival was statistically longer in HRR and PNI low groups than high groups. Conclusion: Both PNI and HRR are associated with poor overall survival in metastatic colorectal cancer.

Article Details

Prognostic significance of prognostic nutritional index and hemoglobin to red cell distribution width ratio in metastatic colorectal cancer patients

Authors:

Ender Doğan | Sedat Tarık Fırat | Murat Eser | Oktay Bozkurt | Mevlüde İnanç

Publisher:

MediHealth Academy Yayıncılık

Main Topics:

Klinik Onkoloji

Journal:

Anatolian Current Medical Journal Vol.5 Issue 4, pp.449-453

Document Type:

Article

Publication Date:

10/2023

Document Language:

English

Document ID (Org No.):

2001302556

pISSN:

2718-0115

Colon cancer

prognostic nutritional index

hemoglobin red cell distribution width ratio

Issues

Article Details

Prognostic significance of prognostic nutritional index and hemoglobin to red cell distribution width ratio in metastatic colorectal cancer patients

Authors: Ender Doğan | Sedat Tarık Fırat | Murat Eser | Oktay Bozkurt | Mevlüde İnanç

Publisher: MediHealth Academy Yayıncılık

Main Topics: Klinik Onkoloji

Journal: Anatolian Current Medical Journal Vol.5 Issue 4, pp.449-453

Document Type: Article

Publication Date: 10/2023

Document Language: English

Document ID (Org No.): 2001302556

pISSN: 2718-0115

Colon cancer

prognostic nutritional index

hemoglobin red cell distribution width ratio

Issues

Authors:

Ender Doğan | Sedat Tarık Fırat | Murat Eser | Oktay Bozkurt | Mevlüde İnanç

Publisher:

MediHealth Academy Yayıncılık

Main Topics:

Klinik Onkoloji

Journal:

Anatolian Current Medical Journal Vol.5 Issue 4, pp.449-453

Document Type:

Article

Publication Date:

10/2023

Document Language:

English

Document ID (Org No.):

2001302556

pISSN:

2718-0115