Hypoglycemia and nitro-oxidative stress in the neonatal period

Chiraz GHADDAB; Nicolas LEFÃ¨VRE; Serge BOTTARİ; Jean-louis WAYENBERG

Article Details

Hypoglycemia and nitro-oxidative stress in the neonatal period

Authors:

Chiraz GHADDAB | Nicolas LEFÃ¨VRE | Serge BOTTARİ | Jean-louis WAYENBERG

Publisher:

Hücresel Sinir Bilimleri ve Oksidatif Stres Derneği

Journal:

Cell Membranes and Free Radical Research 2012 Vol.4 Issue 2, pp.202-208

Document Type:

Article

Publication Date:

8/2013

Document Language:

English

Document ID (Org No.):

2000708981

Frequency:

Tri-annual

eISSN:

2149-7222

Abstract:

 

Peroxynitrite generation and subsequent nitration and/or oxidation of proteins, lipids and DNA are implicated in neuronal death. In animal models, peroxynitrite generation is increased by hypoglycemia, a condition occurring frequently in low birth weight newborns. In order to detect systemic nitro-oxidative stress, we developed an assay to measure plasma nitroalbumin (PNA) concentration and investigated its variations according to the occurrence and recurrence of hypoglycemic events (HG: glycemia < 2.5 mmol/l) during the first day of life. PNA concentrations were measured at days 0, 1 and/or 4 of life in 120 low birth weight newborns (27 small for gestational age term and 93 preterm infants). PNA concentrations at days 0, 1 and 4 were significantly higher in infants who developed at least one HG than in normoglycemic patients. PNA concentration at D1 increased with the number of hypoglycemic events and was correlated to the area under curve of glycemia measured 12-24 hours before sampling. We conclude that hypoglycemia during the first 24 hours of life is associated with increased albumin nitration in newborns. Our results suggest that significant nitro-oxidative stress occurs promptly after hypoglycemia implying a risk of end-organ damage due to protein nitration, lipid peroxidation and DNA damage. Evidence of nitro-oxidative stress in hypoglycemic neonates may open new and exciting perspectives in neuroprotection.

Article Details

Hypoglycemia and nitro-oxidative stress in the neonatal period

Authors: Chiraz GHADDAB | Nicolas LEFÃ¨VRE | Serge BOTTARİ | Jean-louis WAYENBERG

Publisher: Hücresel Sinir Bilimleri ve Oksidatif Stres Derneği

Journal: Cell Membranes and Free Radical Research 2012 Vol.4 Issue 2, pp.202-208

Document Type: Article

Publication Date: 8/2013

Document Language: English

Document ID (Org No.): 2000708981

Frequency: Tri-annual

eISSN: 2149-7222

Issues

Authors:

Chiraz GHADDAB | Nicolas LEFÃ¨VRE | Serge BOTTARİ | Jean-louis WAYENBERG

Publisher:

Hücresel Sinir Bilimleri ve Oksidatif Stres Derneği

Journal:

Cell Membranes and Free Radical Research 2012 Vol.4 Issue 2, pp.202-208

Document Type:

Article

Publication Date:

8/2013

Document Language:

English

Document ID (Org No.):

2000708981

Frequency:

Tri-annual

eISSN:

2149-7222