İnsülin Benzeri Büyüme Faktörü-1 ve Premature Morbiditeleri: Bronkopulmoner Displazi, Premature Retinopatisi, İntraventriküler Kanama ve Nekrotizan Enterokolit

Bayram Ali DORUM; Nilgün KÖKSAL; Hilal ÖZKAN; Salih Çağrı ÇAKIR; Cansu YILMAZ; Taner ÖZGÜR; Ferah BUDAK

Article Details

İnsülin Benzeri Büyüme Faktörü-1 ve Premature Morbiditeleri: Bronkopulmoner Displazi, Premature Retinopatisi, İntraventriküler Kanama ve Nekrotizan Enterokolit

Authors:

Bayram Ali DORUM | Nilgün KÖKSAL | Hilal ÖZKAN | Salih Çağrı ÇAKIR | Cansu YILMAZ | Taner ÖZGÜR | Ferah BUDAK

Publisher:

Bursa Uludağ University

Main Topics:

Diseases

Journal:

The Journal of Current Pediatrics 2019 Vol.17 Issue 2, pp.189-199

Document Type:

Article

Publication Date:

8/2019

Document Language:

Turkish

Document ID (Org No.):

2000804340

Frequency:

Tri-annual

eISSN:

1308-6308

pISSN:

1304-9054

Keywords:

Abstract:

 


Insulin-like growth factor-1 (IGF-1) is important for fetal and postnatal development. After premature births, serum IGF-1 concentrations rapidly decrease and can stay at much lower levels than during the intrauterine period. In this study, we aimed to ascertain whether IGF-1 is associated with morbidities of prematurity such as bronchopulmonary dysplasia (BPD), retinopathy of prematurity (ROP), intraventricular hemorrhage (IVH), and necrotizing enterocolitis (NEC), and is a useful predictor of these diseases.

METHODS: We enrolled newborn infants born at a postmenstrual age of ≤32 weeks in this prospective observational cohort study. Serum IGF-1 levels were measured serially in blood samples on the 1st, 3rd, 7th, 21st, and 28th day.

RESULTS: A total of 93 infants were enrolled in the study. All these infants had the following characteristics at birth: weight 1236.11±354.06 g, and gestational age 29.43±2.10 weeks. All of the IGF-1 levels were significantly lower in the group which developed BPD or ROP (p<0.001). The patients who developed IVH and NEC also had lower IGF-1 levels.

DISCUSSION and CONCLUSION: Strong correlations have been found between low serum IGF-1 levels during the first four weeks and development of BPD and ROP.

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Article Details

İnsülin Benzeri Büyüme Faktörü-1 ve Premature Morbiditeleri: Bronkopulmoner Displazi, Premature Retinopatisi, İntraventriküler Kanama ve Nekrotizan Enterokolit

Authors:

Bayram Ali DORUM | Nilgün KÖKSAL | Hilal ÖZKAN | Salih Çağrı ÇAKIR | Cansu YILMAZ | Taner ÖZGÜR | Ferah BUDAK

Publisher:

Bursa Uludağ University

Main Topics:

Diseases

Journal:

The Journal of Current Pediatrics 2019 Vol.17 Issue 2, pp.189-199

Document Type:

Article

Publication Date:

8/2019

Document Language:

Turkish

Document ID (Org No.):

2000804340

Frequency:

Tri-annual

eISSN:

1308-6308

pISSN:

1304-9054

Bronkopulmoner displazi

insülin benzeri büyüme faktörü-1

prematüre

prematüre retinopatisi

Issues

Article Details

İnsülin Benzeri Büyüme Faktörü-1 ve Premature Morbiditeleri: Bronkopulmoner Displazi, Premature Retinopatisi, İntraventriküler Kanama ve Nekrotizan Enterokolit

Authors: Bayram Ali DORUM | Nilgün KÖKSAL | Hilal ÖZKAN | Salih Çağrı ÇAKIR | Cansu YILMAZ | Taner ÖZGÜR | Ferah BUDAK

Publisher: Bursa Uludağ University

Main Topics: Diseases

Journal: The Journal of Current Pediatrics 2019 Vol.17 Issue 2, pp.189-199

Document Type: Article

Publication Date: 8/2019

Document Language: Turkish

Document ID (Org No.): 2000804340

Frequency: Tri-annual

eISSN: 1308-6308

pISSN: 1304-9054

Bronkopulmoner displazi

insülin benzeri büyüme faktörü-1

prematüre

prematüre retinopatisi

Issues

Authors:

Bayram Ali DORUM | Nilgün KÖKSAL | Hilal ÖZKAN | Salih Çağrı ÇAKIR | Cansu YILMAZ | Taner ÖZGÜR | Ferah BUDAK

Publisher:

Bursa Uludağ University

Main Topics:

Diseases

Journal:

The Journal of Current Pediatrics 2019 Vol.17 Issue 2, pp.189-199

Document Type:

Article

Publication Date:

8/2019

Document Language:

Turkish

Document ID (Org No.):

2000804340

Frequency:

Tri-annual

eISSN:

1308-6308

pISSN:

1304-9054