The Effect of Valproic Acid on Fetal Hemoglobin Synthesis in Children with Epilepsy

Kursat Bora CARMAN; Zeynep Canan ÖZDEMİR; Yeter  Düzenli KAR; Eren GÜNDÜZ; Havva Üsküdar TEKE; Didem ARSLANTAŞ; Coşkun YARAR; Özcan BÖR

doi:https://doi.org/10.20515/otd.411757

Article Details

The Effect of Valproic Acid on Fetal Hemoglobin Synthesis in Children with Epilepsy

Authors:

Kursat Bora CARMAN | Zeynep Canan ÖZDEMİR | Yeter Düzenli KAR | Eren GÜNDÜZ | Havva Üsküdar TEKE | Didem ARSLANTAŞ | Coşkun YARAR | Özcan BÖR

Publisher:

Eskişehir Osmangazi University

Main Topics:

Promotion of health

Journal:

Osmangazi Journal of Medicine 2018 Vol.40 Issue 3, pp.8-12

Document Type:

Article

Publication Date:

8/2018

Document Language:

English

Document ID (Org No.):

2000555979

Frequency:

Bimonthly

eISSN:

2587-1579

pISSN:

1305-4953

DOI:

https://doi.org/10.20515/otd.411757

Abstract:

 


Valproic
acid has been used to treat epilepsy in children. The most common side effects
are hepatotoxicity, anemia and thrombocytopenia. However the effect of valproic
acid on fetal hemoglobin levels has not been revealed adequately. In this study
it was aimed to search the effect of valproic acid on hemoglobin levels in
children receiving valproic acid. In the present cross sectional study the
research group consisted of children with epilepsy who had been receiving
valproic acid monotherapy for at least six months. The control group contained
children without epilepsy or valproic acid medication. The data from 44
patients and 57 controls were analyzed. The mean percentage of HbF of the study
group and control group were 0.48 ±0.96 (%) and 0.25 ±0.61 (%) respectively,
and there was no statistical difference between groups. There was a positive
relation between blood valproic acid level and HbF levels. The present research
showed that valproic acid has no effect on HbF levels. For children on valproic
acid therapy, the detection of increased fetal hemoglobin levels must be
evaluated carefully.



.

 


Valproik asit çocuklarda epilepsi tedavisinde kullanılmaktadır. En sık görülen yan etkileri hepatotoksisite, anemi ve trombositopenidir. Valproik asit bazı hematolojik hastalıklarda tedavi amacıyla kullanılmaktadır. Epileptik hastalarda fetal hemoglobin üzerine olan etkileri tam olarak araştırılmamıştır. Bu vaka kontrol çalışmasında en az altı aydır valproik asit tedavisi alan epilepsi hastası çocuklar ve sağlıklı gönüllüler dahil edilmiştir. Fetal hemoglobin değerleri, ilaç kan düzeyleri araştırılmıştır. Kırk dört epilepsi hastası çocuk ve 57 sağlıklı çocuk araştırmaya dahil edildi. Ortalama fetal hemoglobin (HbF) yüzdesi epilepsi hastalarında ve kontrol grubunda sırasıyla 0.48 ±0.96 (%) ve 0.25 ±0.61 (%) saptandı. Kan valproik asit düzeyi ile HbF düzeyi arasında anlamlı bir ilişki belirlendi. Çalışmamız valproik asit tedavisinin HbF düzeyini etkilemediğini gösterdi. Epileptik hastalarda HbF yüksekliği belirlenmesi durumunda dikkatli bir araştırma gerekmektedir.

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Article Details

The Effect of Valproic Acid on Fetal Hemoglobin Synthesis in Children with Epilepsy

Authors: Kursat Bora CARMAN | Zeynep Canan ÖZDEMİR | Yeter Düzenli KAR | Eren GÜNDÜZ | Havva Üsküdar TEKE | Didem ARSLANTAŞ | Coşkun YARAR | Özcan BÖR

Publisher: Eskişehir Osmangazi University

Main Topics: Promotion of health

Journal: Osmangazi Journal of Medicine 2018 Vol.40 Issue 3, pp.8-12

Document Type: Article

Publication Date: 8/2018

Document Language: English

Document ID (Org No.): 2000555979

Frequency: Bimonthly

eISSN: 2587-1579

pISSN: 1305-4953

DOI: https://doi.org/10.20515/otd.411757

Issues

Authors:

Kursat Bora CARMAN | Zeynep Canan ÖZDEMİR | Yeter Düzenli KAR | Eren GÜNDÜZ | Havva Üsküdar TEKE | Didem ARSLANTAŞ | Coşkun YARAR | Özcan BÖR

Publisher:

Eskişehir Osmangazi University

Main Topics:

Promotion of health

Journal:

Osmangazi Journal of Medicine 2018 Vol.40 Issue 3, pp.8-12

Document Type:

Article

Publication Date:

8/2018

Document Language:

English

Document ID (Org No.):

2000555979

Frequency:

Bimonthly

eISSN:

2587-1579

pISSN:

1305-4953

DOI:

https://doi.org/10.20515/otd.411757