Infections and causative microorganisms in patients with ANCA-associated vasculitis

Gizem Varkal; İpek Türk; Özlem Doğan Ağbuga; Kaniye Aydın; Didem Arslan; Hüseyin Turgut Elbek Özer

Article Details

Infections and causative microorganisms in patients with ANCA-associated vasculitis

Authors:

Gizem Varkal | İpek Türk | Özlem Doğan Ağbuga | Kaniye Aydın | Didem Arslan | Hüseyin Turgut Elbek Özer

Publisher:

Cukurova University

Main Topics:

Klinik Tıp Bilimleri

Journal:

Cukurova Medical Journal Vol.48 Issue 1, pp.253-260

Document Type:

Article

Publication Date:

3/2023

Document Language:

English

Document ID (Org No.):

2001282242

pISSN:

2602-3032

Keywords:

Abstract:

 Purpose: The aim of this study was to detect infections requiring hospitalization in patients with ANCA-associated vasculitis AAV. Materials and Methods: This is a single-center, retrospective study conducted in Turkish patients with AAV. Infection episodes requiring hospitalization, reproducing pathogens, laboratory findings, immunosuppressive treatments given for the treatment of vasculitis, and the relationship with the infection were evaluated. Results: Seventy-four patients diagnosed with AAV were included in the study. Hospitalization due to infection was observed in 36 of the patients. The coexistence of diabetes mellitus DM was found to be significantly higher in the infected patient group. Cyclophosphamide CYC treatment found to increase risk of infection. More than 80 of the infected patient group presented with renal involvement 80.6. A total of 68 infectious episodes were seen in 36 patients. The most common involvement of infection was the respiratory tract with a rate of 70.6. Gram-negative bacteria were the most common pathogen, especially Pseudomonas aeruginosa. With the effect of the pandemic, SARS-CoV-2 has come to the fore among viral infections. Aspergillosis was the most frequently detected among fungal infections. Besides, aspergillosis was the cause of 85.7 6 episodes of fungal infections. Lymphopenia was observed in 76.5 of the infection episodes. 57.4 of infections developed in the first year of the induction therapy. The most frequently used immunosuppressive therapy for the treatment of vasculitis in infectious episodes was CYC 41.2. Conclusion: Managing infections during the vasculitis treatment is crucially important. Lymphopenia, kidney involvement, DM and immunosuppressive therapy are factors that increase the risk of infection. Clinicians should take preventive measure especially for respiratory tract infections and gram-negative bacteria as pathogens.

 Purpose: The aim of this study was to detect infections requiring hospitalization in patients with ANCA-associated vasculitis AAV. Materials and Methods: This is a single-center, retrospective study conducted in Turkish patients with AAV. Infection episodes requiring hospitalization, reproducing pathogens, laboratory findings, immunosuppressive treatments given for the treatment of vasculitis, and the relationship with the infection were evaluated. Results: Seventy-four patients diagnosed with AAV were included in the study. Hospitalization due to infection was observed in 36 of the patients. The coexistence of diabetes mellitus DM was found to be significantly higher in the infected patient group. Cyclophosphamide CYC treatment found to increase risk of infection. More than 80 of the infected patient group presented with renal involvement 80.6. A total of 68 infectious episodes were seen in 36 patients. The most common involvement of infection was the respiratory tract with a rate of 70.6. Gram-negative bacteria were the most common pathogen, especially Pseudomonas aeruginosa. With the effect of the pandemic, SARS-CoV-2 has come to the fore among viral infections. Aspergillosis was the most frequently detected among fungal infections. Besides, aspergillosis was the cause of 85.7 6 episodes of fungal infections. Lymphopenia was observed in 76.5 of the infection episodes. 57.4 of infections developed in the first year of the induction therapy. The most frequently used immunosuppressive therapy for the treatment of vasculitis in infectious episodes was CYC 41.2. Conclusion: Managing infections during the vasculitis treatment is crucially important. Lymphopenia, kidney involvement, DM and immunosuppressive therapy are factors that increase the risk of infection. Clinicians should take preventive measure especially for respiratory tract infections and gram-negative bacteria as pathogens.

 Purpose: The aim of this study was to detect infections requiring hospitalization in patients with ANCA-associated vasculitis AAV. Materials and Methods: This is a single-center, retrospective study conducted in Turkish patients with AAV. Infection episodes requiring hospitalization, reproducing pathogens, laboratory findings, immunosuppressive treatments given for the treatment of vasculitis, and the relationship with the infection were evaluated. Results: Seventy-four patients diagnosed with AAV were included in the study. Hospitalization due to infection was observed in 36 of the patients. The coexistence of diabetes mellitus DM was found to be significantly higher in the infected patient group. Cyclophosphamide CYC treatment found to increase risk of infection. More than 80 of the infected patient group presented with renal involvement 80.6. A total of 68 infectious episodes were seen in 36 patients. The most common involvement of infection was the respiratory tract with a rate of 70.6. Gram-negative bacteria were the most common pathogen, especially Pseudomonas aeruginosa. With the effect of the pandemic, SARS-CoV-2 has come to the fore among viral infections. Aspergillosis was the most frequently detected among fungal infections. Besides, aspergillosis was the cause of 85.7 6 episodes of fungal infections. Lymphopenia was observed in 76.5 of the infection episodes. 57.4 of infections developed in the first year of the induction therapy. The most frequently used immunosuppressive therapy for the treatment of vasculitis in infectious episodes was CYC 41.2. Conclusion: Managing infections during the vasculitis treatment is crucially important. Lymphopenia, kidney involvement, DM and immunosuppressive therapy are factors that increase the risk of infection. Clinicians should take preventive measure especially for respiratory tract infections and gram-negative bacteria as pathogens.

 Amaç: Bu çalışmada ANCA ilişkili vasküliti AİV olan hastalarda hastaneye yatış gerektiren enfeksiyonlarının saptanması amaçlanmıştır. Gereç ve Yöntem: AİVli Türk hastalarda yapılmış tek merkezli, retrospektif bir çalışmadır. Hastanede yatış gerektiren enfeksiyon atakları, üreyen patojenler, laboratuvar bulguları, vaskülit tedavisi için verilen immünsüpresif tedaviler ve enfeksiyon ile ilişkisi değerlendirildi. Bulgular: AİV tanısı alan 74 hasta çalışmaya dahil edildi. Hastaların 36sında enfeksiyon nedeniyle hastaneye yatış görüldü. Enfekte hasta grubunda diabetes mellitus DM birlikteliği anlamlı olarak yüksek bulundu. Siklofosfamid SP tedavisinin enfeksiyon riskini artırdığı bulundu. Enfekte hasta grubunun 80den fazlası böbrek tutulumu ile başvurdu 80,6. Otuz altı hastada toplam 68 enfeksiyon epizodu görüldü. En sık enfeksiyon tutulumu 70,6 ile solunum yolu idi. Gram-negatif bakteriler, özellikle Pseudomonas aeruginosa olmak üzere en yaygın patojendi. Pandeminin de etkisiyle viral enfeksiyonlar arasında SARS-CoV-2 ön plana çıktı. Aspergilloz, mantar enfeksiyonları arasında en sık saptanandı. Ayrıca aspergilloz, mantar enfeksiyonlarının 85,7sinin 6 atak nedeniydi. Enfeksiyon ataklarının 76,5inde lenfopeni gözlendi. Enfeksiyonların 57,4ü indüksiyon tedavisinin ilk yılında gelişmiştir. Enfeksiyöz ataklarda vaskülit tedavisinde en sık kullanılan immünsüpresif tedavi SP 41,2 idi. Sonuç Vaskülit tedavisi sırasında enfeksiyonları yönetmek çok önemlidir. Lenfopeni, böbrek tutulumu, DM ve immünsüpresif tedavi enfeksiyon riskini artıran faktörlerdir. Klinisyenler patojen olarak özellikle solunum yolu enfeksiyonları ve gram negatif bakteriler için önleyici tedbirler almalıdır.

Article Details

Infections and causative microorganisms in patients with ANCA-associated vasculitis

Authors:

Gizem Varkal | İpek Türk | Özlem Doğan Ağbuga | Kaniye Aydın | Didem Arslan | Hüseyin Turgut Elbek Özer

Publisher:

Cukurova University

Main Topics:

Klinik Tıp Bilimleri

Journal:

Cukurova Medical Journal Vol.48 Issue 1, pp.253-260

Document Type:

Article

Publication Date:

3/2023

Document Language:

English

Document ID (Org No.):

2001282242

pISSN:

2602-3032

ANCA-associated vasculitis

infection

immunosuppression

lymphopenia

ANCA ile ilişkili vaskülit

enfeksiyon

immünsüpresyon

lenfopeni

Issues

Article Details

Authors: Gizem Varkal | İpek Türk | Özlem Doğan Ağbuga | Kaniye Aydın | Didem Arslan | Hüseyin Turgut Elbek Özer

Publisher: Cukurova University

Main Topics: Klinik Tıp Bilimleri

Journal: Cukurova Medical Journal Vol.48 Issue 1, pp.253-260

Document Type: Article

Publication Date: 3/2023

Document Language: English

Document ID (Org No.): 2001282242

pISSN: 2602-3032

Issues

Authors:

Gizem Varkal | İpek Türk | Özlem Doğan Ağbuga | Kaniye Aydın | Didem Arslan | Hüseyin Turgut Elbek Özer

Publisher:

Cukurova University

Main Topics:

Klinik Tıp Bilimleri

Journal:

Cukurova Medical Journal Vol.48 Issue 1, pp.253-260

Document Type:

Article

Publication Date:

3/2023

Document Language:

English

Document ID (Org No.):

2001282242

pISSN:

2602-3032