Serum Interleukin 27 Level in Pediatric Patients with Idiopathic Thrombocytopenic Purpura (ITP)

Randa M. Matter; Mahmoud A. Kenny; Nesma A. Safwat; Asmaa M. Elattar

doi:10.12816/0054705

Article Details

Serum Interleukin 27 Level in Pediatric Patients with Idiopathic Thrombocytopenic Purpura (ITP)

Authors:

Randa M. Matter | Mahmoud A. Kenny | Nesma A. Safwat | Asmaa M. Elattar

Publisher:

Ain Shams University : Egyptian Paediatric Society

Main Topics:

Medicine

Journal:

Egyptian Journal of Pediatrics 2019 Vol.36 Issue 3-4, pp.339-348

Document Type:

Article

Publication Date:

12/2019

Document Language:

English

Document ID (Org No.):

137520

Frequency:

Quarterly

pISSN:

16871677

DOI:

10.12816/0054705

Descriptors:

Keywords:

Abstract:

 Background: Immune thrombocytopenia (ITP) is a common autoimmune disorder characterized by immune-mediated accelerated platelet destruction and resulting in isolated thrombocytopenia.Aim of the Work: This study aims at evaluation of prognostic value of interleukin 27 (IL-27) serum level in pediatric patients with acute, persistent and chronic ITP and its relationship with treatment response.Patients and Methods: The study was conducted on 43 patients with ITP from Pediatric Hematology Clinic, Children Hospital, Ain Shams University and 20 age and sex matched normal children as the control group. All the studied children were subjected to thorough history, clinical examination and laboratory investigations, including complete blood count (CBC) and IL-27 serum level using ELISA technique.Results: The study revealed a significant decrease in IL-27 level in ITP patients compared to control group with no significant difference between different categories of ITP as regards IL-27 serum levels. There was no significant relation between category of disease and platelet count, hemoglobin level and IL-27 during blood sampling (p=0.261, 0.426, 0.558 respectively). More than 50% of studied ITP patients received steroids; 76.7% of them did not respond to steroid therapy. There was a positive correlation between IL-27 level and duration of steroid intake in ITP patients (r=0.406, p= 0.04).
Conclusion: The decrease in serum IL27 level in different categories of pediatric ITP patients might suggest its involvement in the pathophysiological process of ITP. IL-27 level might play a role in patients’ response to corticosteroid therapy.

Article Details

Serum Interleukin 27 Level in Pediatric Patients with Idiopathic Thrombocytopenic Purpura (ITP)

Authors:

Randa M. Matter | Mahmoud A. Kenny | Nesma A. Safwat | Asmaa M. Elattar

Publisher:

Ain Shams University : Egyptian Paediatric Society

Main Topics:

Medicine

Journal:

Egyptian Journal of Pediatrics 2019 Vol.36 Issue 3-4, pp.339-348

Document Type:

Article

Publication Date:

12/2019

Document Language:

English

Document ID (Org No.):

137520

Frequency:

Quarterly

pISSN:

16871677

DOI:

10.12816/0054705

Descriptors:

INTERLEUKINS

THROMBOCYTOPENIA

CHILDREN DISEASES

PAEDIATRICS

DIAGNOSIS

EGYPT

Serum Interleukin 27

Idiopathic Thrombocytopenic Purpura

Issues

Article Details

Authors: Randa M. Matter | Mahmoud A. Kenny | Nesma A. Safwat | Asmaa M. Elattar

Publisher: Ain Shams University : Egyptian Paediatric Society

Main Topics: Medicine

Journal: Egyptian Journal of Pediatrics 2019 Vol.36 Issue 3-4, pp.339-348

Document Type: Article

Publication Date: 12/2019

Document Language: English

Document ID (Org No.): 137520

Frequency: Quarterly

pISSN: 16871677

DOI: 10.12816/0054705

Descriptors:

Issues

Authors:

Randa M. Matter | Mahmoud A. Kenny | Nesma A. Safwat | Asmaa M. Elattar

Publisher:

Ain Shams University : Egyptian Paediatric Society

Main Topics:

Medicine

Journal:

Egyptian Journal of Pediatrics 2019 Vol.36 Issue 3-4, pp.339-348

Document Type:

Article

Publication Date:

12/2019

Document Language:

English

Document ID (Org No.):

137520

Frequency:

Quarterly

pISSN:

16871677

DOI:

10.12816/0054705